PSYCH SHELF!

Question 1

Tricyclic antidepressants are used for ?

Answer 1

Depression and chronic pain

Question 2

TCA names?

Answer 2

Imipramine - used for nocturnal enuresis
Amitriptylene - less alpha 1 block
Nortriptyline
Clomipramine - OCD

Question 3

Adverse effects of TCAs?

Answer 3

3Cs: convulsions, coma, cardiac arrhythmias
prolonged QT!
The Anti-HAM:
Anti-H1: sedation
Anti-alpha1: hypotension
Anti-muscarinic: Dry mouth, blurred vision, constipation/urinary retention, and delirium

Question 4

MOA of TCAs?

Answer 4

Decrease NE and 5HT reuptake

Question 5

SSRIs MOA?

Answer 5

5HT2A antagonists

Question 6

SSRI uses?

Answer 6

MDD, PTSD
OCD, Bulemia
Panic Disorder
PMS

Question 7

Names of SSRIs

Answer 7

Fluoxetine

Sertraline

Question 8

SSRI adverse?

Answer 8

nausea, vomit, diarrhea
Decreased libido
Serotonin syndrome:  
     -myoclonus
     -autonomic:  orthostasis, hyperthermia, diarrhea
     -altered mental status

Question 9

MAOIs Names?

Answer 9

Phenelzine, Selegiline, Tranylcypromine, and Isocarboxazid

Question 10

MAOI adverse?

Answer 10

tyramine rich foods (cheese, wine, beer) can trigger hypertensive crisis

Question 11

Mood stabilizer names

Answer 11

Lithium, valproic acid, carbamazepine, lamotrigine

Question 12

Lithium adverse effects

Answer 12

GI distress, tremor, and headache
hypothyroidism
nephrogenic diabetes insipidus
ebstein anomaly

Question 13

valproic adverse effects

Answer 13

jaundice, neural tube defects

Question 14

Schizophrenia

Answer 14

there is a genetic component
Signs for >6 months
delusions and auditory hallucinations
(-) symptoms: decrease affect and anhedonia (no pleasure)

Question 15

tx for schizophrenia

Answer 15

atypical antipsychotics are first line treatment (block dopamine and serotonin receptors). typical antipsych block more D2 receptors

Question 16

MOA of schizophrenia

Answer 16

increase dopamine: positive symptoms
increase serotonin: negative symptoms
decrease NE: anhedonia
brain: ventricular enlargement