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Company Quiz > Psych Papers > Flashcards

Psych Papers Flashcards

1
Q

Cipriani 2018: how many drugs involved?

A

21

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2
Q

Cipriani 2018: how many/ what type patient?

A

116K, most had modarete to severe MDD

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3
Q

Cipriani 2018: duration?

A

8 weeks

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4
Q

Cipriani 2018: how many RCTs?

A

522 double blind

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5
Q

Cipriani 2018: primary end points?

A

efficacy and acceptability

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6
Q

Slee 2019: Number of patients?

A

25 k

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7
Q

Slee 2019: Duration

A

Average 8 weeks

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8
Q

Slee 2019: Study Design

A

89 trials

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9
Q

Slee 2019: Primary Endpoints

A

Efficacy and Acceptability

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10
Q

Slee 2019: Drugs involved

A

22 AD

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11
Q

Martinotti 2012​: Aim

A

Compare Agomelatine and Venlafaxine on anhedonia in MDD patients via SHAPS score

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12
Q

Martinotti 2012​: Number of patients

A

60

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13
Q

Martinotti 2012​: Duration

A

8-weeks

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14
Q

Martinotti 2012​: Study Design

A

Open label, 7-day wash out

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15
Q

Stein 2014: Number of Patients

A

400

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16
Q

Martinotti 2012​: Drugs involved

A

Agomelatine 25-50mg - 8pm
Venlafaxine XR 75-150mg - 8am

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17
Q

Stein 2014: Duration

A

12-weeks

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18
Q

Stein 2014: Study Design

A

Double blind RCT, placebo controlled

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19
Q

Stein 2014: Primary Endpoint

A

HAM-A

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20
Q

Stein 2014: Drugs Involved

A

Agomelatine 25-50mg
Escitalopram 10-20mg
Placebo

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21
Q

In cipriani, which 2 AD had less dropouts than placebo?

A

Fluoxetine and Agomelatine

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22
Q

In Cipriani, which 7 AD were deemed more effective than others (AA EMP VV)?

A

Agomelatine
Amitriptyline
Escitalopram
Mirtazapine
Paroxetine
Venlafaxine
Vortioxetine

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23
Q

In Cipriani, which AD was the only deemed tolerable?

A

Agomelatine

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24
Q

In Slee, which 9 AD were significantly in favour of active drug?

A

Valdoxan
Duloxetine
Mirtazapine
Sertraline
Venlafaxine
Escitalopram
Fluoxatine
Paroxatine
Citalopram

25
Q

In Stein, compare efficacy and tolerability.

A

Similar efficacy but Agomelatine was better tolerated

26
Q

In Stein, what % of patients were given an increased dose?

A

15% Agomelatine
8% Escitalopram

27
Q

In Stein, which medication was significantly better than placebo?

A

Agomelatine

28
Q

In Martinotti, compare anhedonia and efficacy scores.

A

Agomelatine greater anhedonia improvement but similar AD efficacy to venlafaxine XR

29
Q

Sleep Quality VA page: 4 parameters

A

Difficulty falling asleep
Repeated awakenings
Early awakenings
Daytime sleepiness

30
Q

Sleep Quality VA page: number of patients

A

1000

31
Q

Sleep Quality VA page: Duration

A

0, 2 and 12 weeks

32
Q

Sleep Quality VA page: Study design

A

Open label

33
Q

Sleep Quality VA page: Drugs

A

Agomelatine

34
Q

Cao 2021: Study Design

A

Meta-analysis of 42 randomised double-blind trials

35
Q

Cao 2021: Number of patients

A

19k MDD

36
Q

Cao 2021: Durations

A

6-12 weeks

37
Q

Cao 2021: Primary Endpoints

A

Efficacy of treatment on self-rated functional outcomes, using SDS (Sheehan Disability Scale)

38
Q

Cao 2021: Drugs involved

A

13 AD

39
Q

Serretti 2009: Number of patients

A

10 k

40
Q

Serretti 2009: Duration

A

4 - 12 weeks

41
Q

Serretti 2009: Primary endpoints

A

Rate of treatment emergent SD

42
Q

Serretti 2009: according to VA, order that impacted SD, most to lease

A

Ser, Ven, Cit, Par, Fluox, Dul, Esc, Fluv

43
Q

Corruble 2013: Primary endpoints

A
  • Efficacy on depressive symptoms (HAMD)
  • Efficcy on subjective sleep (VAS- sleep visual analouge scale)
44
Q

Corruble 2013: Secondary endpoints

A
  • Global satisfaction on sleep score (PSQI)
  • effect on global functioning
  • effect on emotional experiences (OQESA)
45
Q

Corruble 2013: drugs

A

ago 25-50mg
esc 10-20mg

46
Q

Corruble 2013: number of patients

A

324

47
Q

In the sleep page in the VA, how many patients have trouble falling asleep?

A

9 out of 10

48
Q

In the sleep page in the VA, what questionnaire is used to measure the primary endpoints?

A

CircScreen

49
Q

In Cao 2021, how many AD were more effective than placebo in improving functional outcomes?

A

8

50
Q

In Cao 2021, what SDS score was “meaningful”?

A

A change of 1.5 or greater

51
Q

In Cao 2021, how many AD were seen to have a meaningful change, and which one in particular did not ?

A

Top 7 did. Vortioxetine is the only treatment in the top 8 that did not have meaningful effficacy.

52
Q

In Cao 2021, how many out of the 42 trials, report on all 3 domains? And which AD had the greatest improvement?

A

19, Valdoxan

53
Q

In Serretti 2009, SD occured in what % of patients (not include drugs that were NS)

A

80% - 26%

54
Q

In Serretti 2009, which 3 medication has a NS result, that are in the VA?

A

Mirtazapine, Valdoxan, Moclobemide

55
Q

In Corubble 2013, what were the outcome on emotional experiences.

A

agomelatine had a greater positive outcome on emotional blunting and anhedonia compared to escitalopram

56
Q

In the SDM, which are the 7 “choice” AD?

A

AA EMP VV

ago
ami

esc (lexapro)
mirt (remeron)
parox (paxil)

vort (brint)
venla (effexore)

57
Q

Corrubble 2013: Duration

A

24 weeks

58
Q

SDM source?

A

Mahli et al. 2020 Ranzcp mood disorder guidlines

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