Psych Papers

Question 1

Cipriani 2018: how many drugs involved?

Answer 1

21

Question 2

Cipriani 2018: how many/ what type patient?

Answer 2

116K, most had modarete to severe MDD

Question 3

Cipriani 2018: duration?

Answer 3

8 weeks

Question 4

Cipriani 2018: how many RCTs?

Answer 4

522 double blind

Question 5

Cipriani 2018: primary end points?

Answer 5

efficacy and acceptability

Question 6

Slee 2019: Number of patients?

Answer 6

25 k

Question 7

Slee 2019: Duration

Answer 7

Average 8 weeks

Question 8

Slee 2019: Study Design

Answer 8

89 trials

Question 9

Slee 2019: Primary Endpoints

Answer 9

Efficacy and Acceptability

Question 10

Slee 2019: Drugs involved

Answer 10

22 AD

Question 11

Martinotti 2012​: Aim

Answer 11

Compare Agomelatine and Venlafaxine on anhedonia in MDD patients via SHAPS score

Question 12

Martinotti 2012​: Number of patients

Answer 12

60

Question 13

Martinotti 2012​: Duration

Answer 13

8-weeks

Question 14

Martinotti 2012​: Study Design

Answer 14

Open label, 7-day wash out

Question 15

Stein 2014: Number of Patients

Answer 15

400

Question 16

Martinotti 2012​: Drugs involved

Answer 16

Agomelatine 25-50mg - 8pm
Venlafaxine XR 75-150mg - 8am

Question 17

Stein 2014: Duration

Answer 17

12-weeks

Question 18

Stein 2014: Study Design

Answer 18

Double blind RCT, placebo controlled

Question 19

Stein 2014: Primary Endpoint

Answer 19

HAM-A

Question 20

Stein 2014: Drugs Involved

Answer 20

Agomelatine 25-50mg
Escitalopram 10-20mg
Placebo

Question 21

In cipriani, which 2 AD had less dropouts than placebo?

Answer 21

Fluoxetine and Agomelatine

Question 22

In Cipriani, which 7 AD were deemed more effective than others (AA EMP VV)?

Answer 22

Agomelatine
Amitriptyline
Escitalopram
Mirtazapine
Paroxetine
Venlafaxine
Vortioxetine

Question 23

In Cipriani, which AD was the only deemed tolerable?

Answer 23

Agomelatine

Question 24

In Slee, which 9 AD were significantly in favour of active drug?

Answer 24

Valdoxan
Duloxetine
Mirtazapine
Sertraline
Venlafaxine
Escitalopram
Fluoxatine
Paroxatine
Citalopram

Question 25

In Stein, compare efficacy and tolerability.

Answer 25

Similar efficacy but Agomelatine was better tolerated

Question 26

In Stein, what % of patients were given an increased dose?

Answer 26

15% Agomelatine 8% Escitalopram

Question 27

In Stein, which medication was significantly better than placebo?

Answer 27

Agomelatine

Question 28

In Martinotti, compare anhedonia and efficacy scores.

Answer 28

Agomelatine greater anhedonia improvement but similar AD efficacy to venlafaxine XR

Question 29

Sleep Quality VA page: 4 parameters

Answer 29

Difficulty falling asleep Repeated awakenings Early awakenings Daytime sleepiness

Question 30

Sleep Quality VA page: number of patients

Answer 30

1000

Question 31

Sleep Quality VA page: Duration

Answer 31

0, 2 and 12 weeks

Question 32

Sleep Quality VA page: Study design

Answer 32

Open label

Question 33

Sleep Quality VA page: Drugs

Answer 33

Agomelatine

Question 34

Cao 2021: Study Design

Answer 34

Meta-analysis of 42 randomised double-blind trials

Question 35

Cao 2021: Number of patients

Answer 35

19k MDD

Question 36

Cao 2021: Durations

Answer 36

6-12 weeks

Question 37

Cao 2021: Primary Endpoints

Answer 37

Efficacy of treatment on self-rated functional outcomes, using SDS (Sheehan Disability Scale)

Question 38

Cao 2021: Drugs involved

Answer 38

13 AD

Question 39

Serretti 2009: Number of patients

Answer 39

10 k

Question 40

Serretti 2009: Duration

Answer 40

4 - 12 weeks

Question 41

Serretti 2009: Primary endpoints

Answer 41

Rate of treatment emergent SD

Question 42

Serretti 2009: according to VA, order that impacted SD, most to lease

Answer 42

Ser, Ven, Cit, Par, Fluox, Dul, Esc, Fluv

Question 43

Corruble 2013: Primary endpoints

Answer 43

- Efficacy on depressive symptoms (HAMD) - Efficcy on subjective sleep (VAS- sleep visual analouge scale)

Question 44

Corruble 2013: Secondary endpoints

Answer 44

- Global satisfaction on sleep score (PSQI) - effect on global functioning - effect on emotional experiences (OQESA)

Question 45

Corruble 2013: drugs

Answer 45

ago 25-50mg esc 10-20mg

Question 46

Corruble 2013: number of patients

Answer 46

324

Question 47

In the sleep page in the VA, how many patients have trouble falling asleep?

Answer 47

9 out of 10

Question 48

In the sleep page in the VA, what questionnaire is used to measure the primary endpoints?

Answer 48

CircScreen

Question 49

In Cao 2021, how many AD were more effective than placebo in improving functional outcomes?

Answer 49

8

Question 50

In Cao 2021, what SDS score was "meaningful"?

Answer 50

A change of 1.5 or greater

Question 51

In Cao 2021, how many AD were seen to have a meaningful change, and which one in particular did not ?

Answer 51

Top 7 did. Vortioxetine is the only treatment in the top 8 that did not have meaningful effficacy.

Question 52

In Cao 2021, how many out of the 42 trials, report on all 3 domains? And which AD had the greatest improvement?

Answer 52

19, Valdoxan

Question 53

In Serretti 2009, SD occured in what % of patients (not include drugs that were NS)

Answer 53

80% - 26%

Question 54

In Serretti 2009, which 3 medication has a NS result, that are in the VA?

Answer 54

Mirtazapine, Valdoxan, Moclobemide

Question 55

In Corubble 2013, what were the outcome on emotional experiences.

Answer 55

agomelatine had a greater positive outcome on emotional blunting and anhedonia compared to escitalopram

Question 56

In the SDM, which are the 7 "choice" AD?

Answer 56

AA EMP VV ago ami esc (lexapro) mirt (remeron) parox (paxil) vort (brint) venla (effexore)

Question 57

Corrubble 2013: Duration

Answer 57

24 weeks

Question 58

SDM source?

Answer 58

Mahli et al. 2020 Ranzcp mood disorder guidlines