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Pharmacology > Psych Meds > Flashcards

Psych Meds Flashcards

1
Q

What is the monoamine hypothesis of antidepressants?

A

deficit or decreased function of MOA enzymes, NE, dopamine and serotonin (5-HT)

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2
Q

What is the neurotrophic hypothesis of antidepressants?

A

neurotropic and neuroendocrine factors

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3
Q

what are the most widely used antidepressants?

A

SSRIs

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4
Q

Which antidepressants lack anticholinergic properties?

A

SSRIs, no postural HoTN, conduction defects, change in seizure threshold

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5
Q

What is the black box warning for SSRIs?

A

increased suicidal ideation

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6
Q

Which antidepressant increases risk of bleeding?

A

SSRIs

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7
Q

Which classes of antidepressants, combined with MAOIs can cause serotonin syndrome?

A

SSRIs, SNRIs, TCAs, opioids

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8
Q

What is Fluoxetine (SSRI) and potent inhibitor of?

A

P450 enzymes

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9
Q

Which SSRI enhances the effects of warfarin?

A

Paroxetine

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10
Q

Which SSRI causes dose dependent Qt prolongation, potentially leading to Torsades?

A

citalopram, escitalopram

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11
Q

Which antidepressant class blocks serotonin and NE reuptake?

A

SNRIs

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12
Q

Which SNRI should be avoided in patients with renal and hepatic disease?

A

Duloxetine

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13
Q

Which class of antidepressants are competitive antagonists at muscarinic cholinergic receptors, leading cholinergic effects?

A

TCAs

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14
Q

TCAs are structurally similar to what drugs?

A

local anesthetics and phenothiazines

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15
Q

If your patient is on a TCA which intra-op medication should you be conscious of giving?

A

Ephedrine, exaggerated response with increased circulating catecholamines

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16
Q

Which anticholinergic is best for patients on TCAs?

A

glycopyrrolate

17
Q

Which antidepressants has biphasic elimination?

A

Bupropion (TCA)

18
Q

What are consequences of TCA overdose?

A

inhibit cardiac Ca channels, seizures precede cardiac arrest

19
Q

What is the dose of physostigmine for anticholinergic psychosis from TCA overdose?

A

0.5-2mg

20
Q

Where are MAO-A and MAO-B exclusive to?

A

MAO-A platelets

MAO-B placenta

21
Q

What class of antidepressants form an irreversible complex with MAO enzymes leading to prolonged effects?

A

MAOIs

22
Q

What type of diet do people taking MAOIs follow?

A

tyramine free

23
Q

How do you treat hyperadrenergic crisis from MAOs?

A

vasodilators and anti-dysrhymics

24
Q

What is the treatment for MAOI overdose?

A

Dantrolene

Pharmacology (6 decks)

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