Psych Drugs Flashcards
Haloperidol
(Type, MOA, Mx, S/E)
Typical Antipsychotic - high potency
MOA: Dopamine Antagonist
Mx: Schizophrenia
S/E: Extrapyramidal (Dystonia, muscle rigidity, akathisia, parkinsonism); Hypotension
aka Haldol
Chlorpromazine
(Type, MOA, Mx, S/E)
Typical Antipsychotic - low potency
MOA: Dopamine Antagonist
Mx: Schizophrenia
S/E: Histaminic (sedation); Alpha adrenergic (orhostatic hypotension); Anticholinergic (Dry Mouth)
aka Thorazine
Fluphenazine
(Type, MOA, Mx, S/E)
Typical Antipsychotic - high potency
MOA: Dopamine Antagonist
Mx: Schizophrenia
S/E: Extrapyramidal (Dystonia, muscle rigidity, akathisia, parkinsonism); Hypotension
aka Proxlixin
Aripiprazole
(Type, MOA, Mx, S/E)
Atypical Antipsychotic
MOA: Partial agonist of D2 receptor and some 5-HT receptors (1A,2C). Antagonises some 5-HT receptors (2A, 7)
Mx: Schizophrenia
S/E: Weight Gain; headache; agitation;
aka Abilify
Risperidone
(Type, MOA, Mx, S/E)
Atypical Antipsychotic
MOA: Dopamine Antagonist plus Anti-serotonergic/adrenergic/histaminergic
Mx: Schizophrenia; Schizoaffective Disorder; mixed/manic bipolar state
S/E: Hyperprolactinaemia; Weight Gain; Others
aka Risperdal
Clozapine
(Type, MOA, Mx, S/E)
Atypical Antipsychotic
MOA: Dopamine Antagonist plus Anti-serotonergic/adrenergic/histaminergic
Mx: Schizophrenia
S/E: Agranulocytosis; Cardiac Toxicity; GI Hypomotility; Hypersalivation (M4 agonist); Weight Gain;
aka Clozaril
Olanzopine
(Type, MOA, Mx, S/E)
Atypical Antipsychotic - Thienobenzodiazepine
MOA: Dopamine Antagonist plus Serotonin Antagonist
Mx: Schizophrenia
S/E: Weight Gain; Paradoxical Reactions (personality/thought/hallucinations); Others
aka Zyprexa
Citalopram
(Type, MOA, Mx, S/E)
Antidepressant
MOA: Selective Serotonin Reuptake Inhibitor
Mx: Depression; Panic Disorder;
S/E: Sexual Dysfunction (Less libido, anorgasmia, ejaculatory anhedonia); Antihistaminergic (sedation); Weight Gain; Suicide
aka Celexa, Cipramil
Fluoxetine
(Type, MOA, Mx, S/E, C/Is)
Antidepressant
MOA: Selective Serotonin Reuptake Inhibitor
Mx: Depression; OCD; Panic Disorder;
S/E: Sexual Dysfunction (Less libido, anorgasmia, ejaculatory anhedonia); Suicide
C/Is: Prior use of MAOIs within two weeks otherwise risk serotonin syndrome
Sertraline
(Type, MOA, Mx, S/E)
Antidepressant
MOA: Selective Serotonin Reuptake Inhibitor
Mx: Depression; OCD; Panic Disorder;
S/E: Sexual Dysfunction (Less libido, anorgasmia, ejaculatory anhedonia); Suicide
aka Zoloft
Isocarboxazid
(Type, MOA, Mx, S/E)
Antidepressant - Hydrazine class
MOA: Non-selective, irreversible MAOI
Mx: Depression; Anxiety
S/E: Headaches; Jaundice; Weight Gain; Orthostatic Hypotension; Tremors; Others
aka Marplan
Moclobemide
(Type, MOA, Mx, S/E)
Antidepressant - Benzamide
MOA: Selective, Reversible inhibitor of MAO-A (RIMA) leading to increased noradrenaline, dopamine and serotonin.
Mx: Depression; Anxiety
S/E: Insomnia; Headache; Dizziness
aka Amira
Selegiline
(Type, MOA, Mx, S/E)
Antidepressant - Phenethylamines
MOA: Selective, Reversible inhibitor of MAO-B (larger doses it becomes MAO-A selective too)
Mx: Depression; Parkinson’s Disease (enhances efficacy of levodopa)
S/E: Dizziness; Dry Mouth; Insomnia
aka Selgene
Amitriptyline
(Type, MOA, Mx, S/E, C/Is)
Tricyclic Antidepressant
MOA: Serotonin-norepinephrine reuptake inhibitor
Mx: Depression
S/E: Dizziness; Dry Mouth; Insomnia; Delirium; Confusion; Anxiety; Agitation
C/Is: History of MI/CHF/arrhythmias; Mania; Liver disease
aka Amitrip
Reboxetine
(Type, MOA, Mx, S/E, C/Is)
Antidepressant
MOA: Norepinephrine reuptake inhibitor
Mx: Depression
S/E: Nausea; Insomnia; insomnia; dizziness; dry mouth
C/Is: MAOIs; narrow angle glaucoma
aka Davedax
Duloxetine
(Type, MOA, Mx, S/E, C/Is)
Antidepressant
MOA: Serotonin-norepinephrine reuptake inhibitor
Mx: Depression; GAD
S/E: Nausea; Somnolence; insomnia; dizziness; dry mouth
C/Is: MAOIs; narrow angle glaucoma
aka Cymbalta
Lithium
(Type, MOA, Mx, S/E, C/Is)
Mood-stabiliser
MOA: Serotonin-norepinephrine reuptake inhibitor
Mx: Bipolar
S/E: Tremor; Polydipsia; Polyuria; Weight Gain; Thyrotoxicity; Nephrotoxicity; Leukocytosis
C/Is: Pregnancy
aka Camcolit
Valproate
(Type, MOA, Mx, S/E, C/Is)
Mood-stabiliser + Anti-convulsant
MOA: Inhibits GABA breakdown, Na channel blocker,
Mx: Bipolar; Epilepsy
S/E: Nausea; Vomiting; Tremors; Sedation; Weight Gain; Transient hair loss; Thrombocytopenia; Hepatotoxicity; Pancreatitis
C/Is: Pregnancy
aka Epilim
Carbamezapine
(Type, MOA, Mx, S/E, C/Is)
Mood-stabiliser + Anti-convulsant
MOA: GABA receptor agonist, Na channel blocker,
Mx: Bipolar; Epilepsy
S/E: Drowsiness; dizziness; ataxia; diplopia; agranulocytosis; hyponatraemia
C/Is: Pregnancy
aka Tegretol
Diazepam
(Type, MOA, Mx, S/E, C/Is)
Benzodiazepine
MOA: positive allosteric modulator of GABA-A receptors
Mx: Anxiety; Panic; Acute Alcohol Withdrawal; Anti-convulsion
S/E: Ataxia; Drowsiness; Confusion; Amnesia; Paradoxical (nervousness, irritability, etc.)
C/Is: Pregnancy
aka Valium
