Psych drug SE and CI

Question 1

What are the SE of TCA

Answer 1

Anticholinergic (Anti-M1)
-dry mouth, blurred vision, constipation, urinary retention, drowsiness, confusion, palpitation/tachy

Adrenergic antagonism
-drowsiness, postural hypotension, tachy, sexual dysfunction

5 HT antagonism
-anxiolytic, sexual dysfunction, sedation

Anti-histaminergic
-Drowsiness, weight gain

Question 2

What are some CI of TCA

Answer 2

Suicidal - cardiotoxic

Acute MI

Heart block

Arrthymias

IHD

Severe liver disease

Pregnancy and lactation

Question 3

Whatis the mechanism of action of MAO-i

Answer 3

Irreversible inhibition of MAO-A&B leading to accumulation of monoamines in synaptic cleft

Question 4

What are the SE of MAOi

Answer 4

HTN crisis
Antimuscarinic
Hepatotoxicity

Insomnia
Anxiety

Appetite suppresion
Weight gain

Postural hypotension
Ankle oedema

Sexual dys

Question 5

What are some sources of tyramine

Answer 5

Cheese
Meat and yeast extract
Broad beans
Avocado

Question 6

What are some CI of MAOi

Answer 6

CVD
Hepatic failure
Poorly controlled HTN

Question 7

SE of SSRI

Answer 7

GI symptoms
-nausea
-vomiting 
-
Headache
Insomnia

Question 8

CI of SSRI

Answer 8

Manic episode

Concomitant use of MAOi

Question 9

SE of antipsychotics

Answer 9

Typical
-extrapyramidal

atypical
-metabolic - weight gain

Both

• hyperprolactinaemia (Sexual dysfunction - ED, decreased libido )
• Diabetes
• VTE in elderly
• postural hypotension
• seizures
• anticholinergic SE