Psych (B+W) Flashcards
What is a common side effect that SSRIs DONT have?
impotence (rare)
What are the more severe side efffects of TCAs?
confusion
sedation (good for people with insomnia at night)
orthostatic hypotension
prolonged QRS
What are the common side effects with MAOIs
Serotonin syndrome (interaction with SSI, meperidine (demerol), pseudoephedrine)–> hyperthermia, muscle rigidity and altered mental status
Hypertensive crisis–malignant hyperthermia when ingested with foods rich in tyramine (wine and cheese)
What are the SNRIs
Mirtazapine and Duloxetine
What is a side effect associated with Mirtazapine?
agranulocytosis
what is required to diagnose MDD?
two depressive episodes >2 weeks each, separated by 2 months
What is dysthymic disorder?
steady depressive sx for at least 2 years (if major depressive episode occurs during the 2 yrs, then the Dx is MDD rather than dysthymic disorder
What is the treatment for dysthymic disorder?
Same as MDD
How distinguish bereavement from MDD?
Bereavement has to be <2months
What drug toxicities should you consider in a patient who may have bipolar disorder?
cocaine, amphetamine
What is the difference between a manic episode and a hypomanic episode?
manic cause significant disability, hypomanic have the same sx but do not cause a significant disability
What are the diagnostic clues for bipolar disorder
- manic episodes causing significant disability
2. episode lasting at least 1 week, abrupt, not continuous
What is the difference between Bipolar I, bipolar II and rapid cycling
Bipolar 1 : manic episode with or without depressive episodes (often depression before mania)
Bipolar 2: depressive episodes with hypomanic episodes and NO manic episodes
Rapid cycling: four episodes (depressive, manic or mixed) in 12 months, **can be precipitated by antidepressants
What are the first line treatments for bipolar disorder?
Valproate and lithium
What is a common side effect with Valproate and carbamazepine?
blood dyscrasias
What are symptoms of lithium toxicity?
tremor
polyuria from nephrogenic DI
What drugs are commonly the cause of drug induced mania?
cocaine
amphetamines
An ECG arrhytmia or ischemia in a young person should make you suspicious of what?
Drug induced mania (also tachy, HTN, dilated pupils)
How treat drug-induced mania?
Ca-channel blockers for acute autonomic sx (drug programs are better for the long-term)
What are the hallmark symptoms of psychosis?
hallucinations and delusions
How treat someone with psychosis who has compliance issues?
depot of Haldol which administers a 1mo supply of drug in a IM injection
What are examples of negative symptoms?
flat or lack of affect, avolition, alogia (poverty of speech)
What are positive symptoms?
hallucinations and delusions
What are the timelines for schizophrenia vs. schizophreniform vs. brief psychotic disorder?
Brief psychotic disorder - 1d to 1mo
Schizophreniform - 1-6mo
Schizophrenia - >6mo continuous
What is a delusional disorder?
non-bizarre delusion, i.e. things that are possible, like a cheating spouse, etc, WITHOUT hallucinations, disorganized speech or behavior
What kind of hallucinations do LSD and PCP cause?
primarily visual, taste, touch or olfactory
what drugs cause paranoid delusions and feeling like bugs are crawling on your skin?
cocaine and amphetamines
what drug can cause psychosis and mood disturbances early in the course of therapy?
corticosteroids
What has a higher potency, chlorpromazine or haloperidol?
haloperidol
What are the adverse effects of haldol?
decreased anticholinergic effects, increased movement effects
what are the adverse effects of chlorpromazine?
increased anticholinergic effects (ch in this and chlorpromazine), and decreased movement effects
What are the adverse effects with Clozapine
1% incidence of agranulocytosis–> weekly CBC
lowers seizure threshold
What are the side effects of Risperidone?
- rare movement disorders (though can occur at high doses)
- new onset diabetes
What are the side effects of Olanzapine, quetiapine, ziprasidone and aripiprazole?
- new onset diabetes
- ziprasidone and aripiprazole can cause LESS weight gain
How long does a panic disorder attack usually last?
escalate for 10 mins, remain for ~30 mins (rare to last over an hour)
If a young pt with symptoms of an MI presents, what dx should you consider?
panic disorder
How dx panic disorder?
dx of exclusion of medical condition and drug abuse
Treatment options for panic disorder?
SSRIs SNRIs TCAs cog/behav tx respiratory relaxation training
What is acute dystonia? How long does it last?
sustained muscle spasm anywhere in body but often in neck (torticollis), jaw or back
lasts 4hrs–> 4days
Tx for acute dystonia?
immediate IV diphenhydramine
What is parkinsonism? Time course?
cogwheel rigidity, shuffling gait, resting tremor
4days–>4months
what is the tx for parkinsonism?
benztropine (anticholinergic)
What is tardive dyskinesia? time course?
involuntary, irregular movements of head, tongue, lips, limbs and trunk
4mo–>4yrs
Tx for tardive dyskinesia?
immediately change meds or decrease doses b/c effects are often permanent
What is akathisia? time course
Subjective sense of discomfort that leads to restlessness (pacing, sitting down and getting up)
Any Time
Tx for akathisia?
lower medication doses
What is neuroleptic malignant syndrome
life threatening muscle rigidity with fever, increase BP and HR, rhabdomyolysis over 1-3 days
Labs: increased WBC, CK, transaminases, myoglobin and myoglobinuria
Tx for neuroleptic malignant syndrome?
Supportive, stop drug and give dantrolene (which inhibits calcium release into cells), cool patient to prevent hypoxia
What is agoraphobia?
fear of being in situations where escaping would be very difficult should a panic attack arise
What is the treatment for phobias?
Beta-blockers for prophylaxis
Exposure desensitization: exposure to noxious stimulis in increments while undergoing concurrent relaxation
What is the difference between obsessions and compulsions?
obsessions = recurrent thought compulsions = recurrent act
obsessive thought causes anxiety and the compulsion is a way of temporarily relieving the anxiety
What is the difference between OCD and obsessive-compulsive personality disorder?
OCD - aware/recognize the absurdity
OC personality disorder - don’t see anything wrong with compulsion
Treatment for OCD?
SSRIs or clomipramine, CBT in which patient is forced to overcome the behavior
What are some of the hallmark symptoms of PTSD?
- reliving initial incident via conscious thoughts or dreams
- avoiding public places and activities
- depression, moodiness, difficulty sleeping and concentrating
What is the difference between Acute Stress Disorder and PTSD?
Acute stress disorder also requires a traumatic incident, but sx are more immediate (within 4 wks of event) and last <4wks time
Tx for PTSD?
SSRIs are first line
**watch out re Benzos b/c there is a high association between substance abuse and PTSD
What is Generalized Anxiety Disorder?
worry for most days for at least 6 months
- irritable, inability to concentrate, insomnia, fatigue, restlessness
- need evidence of social dyfucntion (ex. poor school grades, mental stagnation, etc.)
Tx for GAD?
psychotherapy because problem is chronic
CBT
Biofeedback and relaxation techniques
Pharm: Buspirone, B-blockers for peripheral sx like tachycardia, but doesn’t address the worry)
What is a general symptom of personality disorders?
pervasive pattern of maladaptive behavior causing functional impairment
consistent behavior often traced to childhood
-pts usually don’t see anything wrong with their behavior
What are ego defenses?
unconscious mental processes that individuals resort to in order to quell inner conflicts and anxiety that are inacceptable to the ego (ex. denial and projection)
What are Cluster A personality disorders?
Paranoid, schizoid and schixotypal (weird or eccentric)
What are Cluster B personality disorders?
Borderline, antisocial, histrionic and narcissistic (dramatic, wild and aggressive)
What are Cluster C personality disorders?
Avoidant, dependent, and obsessive compulsive (shy and nervous)
What is acting out
transforming unacceptable feeling into actions, ex. tantrum
What is displacement?
redirection of some emotion from a real source to a substitute person or object
What is introjection?
identifying with some idea or object so deeply that it becomes a part of that person
What is projection?
attributing unacceptable thoughts, feelings, behaviors and motives to others
Paranoid personality disorder characteristics?
- negatively interpret actions and words of others
- often use projection as ego defense (attribute to other people impulses and thoughts that are unacceptable to self)
- do not hold fixed delusions or have hallucinations
Schizoid personality disorder
-socially withdrawn, introverted
-don’t feel need to form close emotional ties with others
-can recognize reality
(D for distant)
Schizotypal personality disorder
Believe in concepts not considered real by rest of society/culture (magiv, vlairvoyance)
- Ego defense: fantasy
- no necessarily psychotic
- usually socially isolated
- often related to schizophrenics
Antisocial personality disorder
violate rights of others, break law
Dx: have to have exhibited behavior BY age 15, BUT have to BE at least 18 for Dx
DDx = conduct disorder which is bad behavior dx in kids
Borderline
- volatile emotionally
- Ego defense: splitting
- self-destructive behavior
- can disassociate: forget negative experiences by covering them up with overly exuberant positive behavior
Histrionic
- require everyone’s attention
- use disassociation and repression (block feelings unconsciously)
What is the difference between repression and supression?
Repression = blocking feelings consciously Supression = consciously blocking feelings
Narcissistic
feeling entitled, because they are the best ande veryone else in inferior
handle criticism poorly
Dependent personality disorder
can’t do much on own, can’t be alone
Avoidant personality disorder
Feel inadequate, very sensitive to negative comments
Reluctant to try new things for fear of embarassment
Obsessive Compulsive Personality Disorder
preoccupied with detail
Isolation is a common ego defense
What is rationalization?
making the unreasonable seem acceptable (ex. if you get fired, saying that you wanted to quit anyway)
What is Reaction formation
setting aside unconscious feelings and expressing the exact opposite feelings (showing extra affection for someone you hate)
What is Sublimation?
taking instinctual drives (ex. sex) and funneling that energy into a socially acceptable action (studying) behavior or emotion
What is the difference between factitious disorder and malingering?
Factitious disorder = consciously faking or manipulating sx to ‘assume the sick role’ but not for material gain
Malingering = consciously faking sx for material gain
Munchhausen is an example of what kind of disorder?
Factitious Disorder
What is somatoform Disorder?
ex. female pt with problems starting before age 30 w/history of frequent visits to the doctor for countless procedures and operations (often exploratory) and h/o abusive or failed relationships
treatment for somatoform disorder
continuity of care, regular appointments so pt can express sx, perform phys exam but don’t order labs, eventually suggest psych
What is conversion disorder?
neuro sx, not consciously faked
sensory defecits usually fail to correspond to a known pathway
Dx: identify a stressor that preciptated the sx and exclude an adequate medical illness
**some of these patients may be found to have a non-psychiatric cause of illness
Hypochondriasis
preocupation with dz, misinterprets sx as suggestive of something serious
Body dysmorphic disorder definition? Tx?
concern with body, usually 1 feature, imagines defecits that other people don’t see, exagerrate any slight imperfections if present
Tx = SSRIs
Autism
pervasive developmental disorder that covers many areas of development from language, social interaction to emotional reactivity
- child is ‘living in own world’
- sx begin by age 3
Aspergers
autism without language impairment
Depression in kids and teens
kids: can be hyperactive and aggressive
teens: can show boredom, irritability, openly antisocial behavior
+ adult sx
Sx of Separation anxiety and Tx
sleep disturbance and somatic sx during times of separation (headache, upset stomach)
Tx: desensitizing, imipramine sometimes used
Tx for ADHD?
methylphenidate, amphetamine (Ritalin, Concerta, Adderal)
Tourette’s Dx
require a motor tic and vocal tic for >1yr
vocal tics are usually obscene
Tx for Tourette’s
Haldol
Anorexia Dx
<85% expected body weight
Amenorrhea secondary to weight loss
restrictive eating
need to monitor electrolytes to prevent cardiac sx
Bulemia
binge eating and purging
more common than anorexia
can have nml appearance
Abrasion over knuckles and dental erosion
Cocaine/amphetamine withdrawal sx
hypersomnolence, dysphoria, increased appetite