Psych (B+W) Flashcards
What is a common side effect that SSRIs DONT have?
impotence (rare)
What are the more severe side efffects of TCAs?
confusion
sedation (good for people with insomnia at night)
orthostatic hypotension
prolonged QRS
What are the common side effects with MAOIs
Serotonin syndrome (interaction with SSI, meperidine (demerol), pseudoephedrine)–> hyperthermia, muscle rigidity and altered mental status
Hypertensive crisis–malignant hyperthermia when ingested with foods rich in tyramine (wine and cheese)
What are the SNRIs
Mirtazapine and Duloxetine
What is a side effect associated with Mirtazapine?
agranulocytosis
what is required to diagnose MDD?
two depressive episodes >2 weeks each, separated by 2 months
What is dysthymic disorder?
steady depressive sx for at least 2 years (if major depressive episode occurs during the 2 yrs, then the Dx is MDD rather than dysthymic disorder
What is the treatment for dysthymic disorder?
Same as MDD
How distinguish bereavement from MDD?
Bereavement has to be <2months
What drug toxicities should you consider in a patient who may have bipolar disorder?
cocaine, amphetamine
What is the difference between a manic episode and a hypomanic episode?
manic cause significant disability, hypomanic have the same sx but do not cause a significant disability
What are the diagnostic clues for bipolar disorder
- manic episodes causing significant disability
2. episode lasting at least 1 week, abrupt, not continuous
What is the difference between Bipolar I, bipolar II and rapid cycling
Bipolar 1 : manic episode with or without depressive episodes (often depression before mania)
Bipolar 2: depressive episodes with hypomanic episodes and NO manic episodes
Rapid cycling: four episodes (depressive, manic or mixed) in 12 months, **can be precipitated by antidepressants
What are the first line treatments for bipolar disorder?
Valproate and lithium
What is a common side effect with Valproate and carbamazepine?
blood dyscrasias
What are symptoms of lithium toxicity?
tremor
polyuria from nephrogenic DI
What drugs are commonly the cause of drug induced mania?
cocaine
amphetamines
An ECG arrhytmia or ischemia in a young person should make you suspicious of what?
Drug induced mania (also tachy, HTN, dilated pupils)
How treat drug-induced mania?
Ca-channel blockers for acute autonomic sx (drug programs are better for the long-term)
What are the hallmark symptoms of psychosis?
hallucinations and delusions
How treat someone with psychosis who has compliance issues?
depot of Haldol which administers a 1mo supply of drug in a IM injection
What are examples of negative symptoms?
flat or lack of affect, avolition, alogia (poverty of speech)
What are positive symptoms?
hallucinations and delusions
What are the timelines for schizophrenia vs. schizophreniform vs. brief psychotic disorder?
Brief psychotic disorder - 1d to 1mo
Schizophreniform - 1-6mo
Schizophrenia - >6mo continuous