Psych Flashcards

1
Q

What are the core symptoms of depression?

A
  1. Low mood
  2. Loss of energy (anergia)
  3. Anhedonia - loss of enjoyment of formerly pleasurable activities
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2
Q

Name some other symptoms of depression.

A
Early morning wakening 
change in appetitie
change in sex drive
diurnal variation of mood - lowest in morning 
agitation
loss of confidence 
loss of concentration
guilt
hopelessness
suicidal ideation
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3
Q

What is the ICD10 diagnostic criteria for clinical depression?

A

At least 2 of the 3 core symptoms
present every day
for at least 2 weeks

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4
Q

What are some risk factors for depression?

A
Family hx 
hx of abuse
drug and alcohol abuse
low socioeconomic status 
having a chronic disease
traumatic life event
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5
Q

What are some medical causes for depression?

A

hypothyroidism
physical health problems/chronic disease
medications - isoretinoin (roccutane), beta blockers
childbirth

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6
Q

What are some non-medical treatments for depression?

A

self-help groups
guided self help
computerised CBT
individualised CBT or onterpersonal therapy
psycholoigcal therapy with antidepressants

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7
Q

What are some medical treatments for depression?

A

antidepressants - continue for at least 6 months after symptoms stop

resistant depression = antidepressants + lithium/atypical antipyschotic/another antidepressant

ECT

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8
Q

Name some classes of antidepressants, give examples of drugs within them.

A

SSRIs - sertraline, citalopram, fluoxetine

SNRIs - venlafaxin, duloxetine
inhibits 5HT reuptake pumps and NAd transporter

MAOIs - isocarboxazid, seligiline - can lead to hypertensive crisis and can cause migraine

TCAs - amitryptyline

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9
Q

What are some side effects of SSRIs?

A
GI symptoms 
sexual impotence 
weight gain
increased bowel motility 
agitation
increased risk of GI bleed if taking NSAID so give PPI
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10
Q

Which drugs do SSRIs interact with?

A

NSAIDs - add PPI if giving SSRI
Warfarin/heparin - avoid SSRI, consider mirtazapine (SNRI)

Aspirin - give PPI

Triptans - avoid SSRI

NB: fluoxetine and paroxetine have higher risk of interaction

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11
Q

Which SSRI is given first line in children and adolescents?

A

Fluoxetine

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12
Q

Which SSRI is given first line for generalised anxiety disorder?

A

Setraline

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13
Q

What are some discontinuation symptoms of SSRIs?

A
incresed mood change 
restlessness
difficulty sleeping
unsteadiness
sweating 
GI symptoms - pain, cramping, diarrhoes, vomiting 
paraesthesia
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14
Q

What are some side effecs of tricyclic antidepressants?

A

urinary retention - anticholinergic effects
Dry mouth
lethargy/drowsiness
constipation

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15
Q

Name some risk factors for suicide following self harm.

A

single
homeless
unemployed/stressful job
poor social support
type of self harm - superficial vs deep cuts
whether they regret the self harm or express the desire t do it again

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16
Q

Define bipolar affective disorder.

A

recurrent episodes of altered mood and activity

involving both upswings and downswings (hypomania/mania + depression)

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17
Q

What’s the difference between bipolar 1 and 2?

A

Bipolar 1 - mania + depression, sometimes more episodes of mania

Bipolar 2 - more episodes of depression and only mild hypomania

Cyclothymia - chronic mood fluctuations over at least 2 years. Episodes of depression and hypomania Rapid cycling, episodes only last a few days.

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18
Q

What are the risk factors for bipolar disorder?

A

strong genetic component
traumatic life event
hx of abuse
sleep deprivation can cause mania

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19
Q

What is the peak age of onset of bipolar disorder?

A

Early 20s

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20
Q

What are the symptoms of hypomania?

A

Lasting at least 4 days -

elevated mood
increased energy 
increased talktativeness
poor concentration 
mild reckless behaviour (overspending) 
overfamliarity 
increased libido/sexual disinhibition 
increased confidence 
decreased need to sleep 
change in appetitie
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21
Q

What are the symptoms of mania?

A

Lasting over 1 week and more extreme than hypomania -

extreme, uncontrollable elation 
overactivity 
pressured speech 
impaired judgement 
extreme risk taking behaviour 
social disinhibition 
inflated self-esteem, grandiosity 
mood congruent psychotic symptoms 
insight is often absent
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22
Q

What is the main feature that differentiates mania from hypomania?

A

presence of psychotic symptoms such as auditory hallucinations and grandiose delusions

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23
Q

What are some differential diagnoses for bipolar disorder?

A

substance abuse - amphetamines, cocaine
endocrine disease - Cushing’s, steorid-induced psychosis
schizophrenia
schizoaffective disorder
personality disorders - EUPD, histrionic
ADHD in younger people

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24
Q

How do you treat an episode of acute mania?

A

antipsychotics - haloperidol, olanzapine, quetipine, risperidone

lithium

Benzos for acute behavioural disturbance

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25
What are the longer term treatments used for bipolar disorder?
mood stabilisers - lithium, valproate, carbamazepine during pregnancy use antipsychotics
26
How are severe depressive episodes of bipolar disorder treated?
Quetiapine olanzapine (+/- fluoxetine) lamotrigine
27
Things to be aware of on lithium...
``` L- leucocytosis I - insipidus diabetes (nephrogenic) T - tremors (if coarse, think toxicity) H - hydration I - increased GI motility U - underactive thyroid M - metallic taste, mums beware - teratogenic ``` Lithium + diuretics = beware dehydration Lithium + NSAIDs = beware kidney damage
28
Name some side effects of lithium.
``` weigth gain nephrotoxicity tremor diabetes insipidus hypothyroidism ```
29
What are the symptoms of lithium toxicity?
``` dry mouth/extreme thirst strange movements very sleepy nausea and vomiting diarrhoea confusion ``` basically act like a drunk person
30
Define dysthymia.
chronic, mildly depressed mood and diminished enjoyment not severe enough to be depression at least 2 years tx with SSRIs and CBT
31
What are some risk factors for post-partum depression?
``` Past psychiatric hx conflicting feelings about the pregnancy hx of abuse as a child USS showing foetal abnormalities low socioeconomic status lack of supportive relationships ```
32
What is the first-line tx for post-partum depression?
psycholoigcal therapy | because if breastfeeding - antidepressants can have adverse effect on the baby
33
What are the causes/risk factors for schizophrenia?
``` family hx/genetic link insult to brain development in early life smoking cannabis in adolescence severe childhood bullying socioeconomic depreivation adverse life events ```
34
What is the pathophysiology of schizophrenia?
dopamine excess - overactivity in mesolimbic and corticolimbic dopaminergic pathways
35
What is the typical age of onset of schizophrenia?
20-30s
36
How is a diagnosis of schizophrenia made?
at least 1 first-rank symptom or at least 2 second rank symptoms for a duration of at least 1 month
37
What are the first rank symptoms of schizophrenia?
3rd person auditory hallucinations (running comentary, hears people talking ABOUT them) thought disorder/alienation - broadcast, withdrawal, insertion, deletion passivity phenomenon - made to do or feel things against their will - as if someone is controlling their thoughts, feelings and actions
38
What are the second rank symptoms of schizophrenia?
``` delusions 2nd person auditory hallucinations any other modality of hallucination formal thought disorder (words come out wrong becasue thoughts are muddled) catatonic behaviour negative symptoms ```
39
What are the positive symptoms of schizophrenia?
delusions hallucinations formal thought disorder
40
What are the negative symptoms of schizophrenia?
``` poverty of speech flat affect poor motivation social withdrawal lack of concerns for social conventions ```
41
What are the cognitive symptoms of schizophrenia?
poor attention and memory
42
What are the differential diagnoses for patients presenting with psychotic symptoms like hallucinations and delusions?
``` schizophrenia schizoaffective disorder delusional disorder brief/acute psychotic episodes (if they last < 1 month, then not schizophrenia) drug induced psychosis SOL - brain tumour or abscess ```
43
What are the side effects of antipsychotics?
diabetes/insulin resistance and dyslipidaemia QT segment changes on ECG agranulocytosis - clozapine extra-pyramidal side effects due to dopamine blockade urinary retention blurred vision weight gain hyperprolactinaemia (dopamine bloackade --> dopamine downregulates prolactin)
44
What are the 4 EPSEs of antipsychotics?
acute dystonia (hours) - muscle spasm, acute torticollis, eyes rolling back parkinsonism (days) - tremor, bradykinesia Akathisia (days to weeks) - inner restlessness, pacing and intolerable agitation tradive dyskinesia (months t years) - grimacing, tongue protrusion, lipsmacking
45
How are the EPSEs from antipsychotics treated?
Procyclidine (anticholinergic)
46
Define generalised anxiety disorder.
general persistent, excessive worry about a number of different events individual finds the worry difficult to control for at least 3 weeks (ICD) or 6 months (DSM) no particular stimulus often comorbid with depression, substance misuse etc
47
What are the risk factors for GAD?
``` alcohol use benzo use stimulants - esp if withdrawing co-existing depression family hx childhood abuse, neglect excessively pushy parents life stresses/events physical health problems ```
48
What medical conditions can cause GAD?
``` hyperthyroidism phaeochromocytoma lung disease - excessive use of salbutamol congestive heart failure - heart meds hypoglycaemia ```
49
What are the symptoms of GAD?
``` unpleasant/fearful emotional state bodily discomfort physical symptoms - palpitations, tachycardia, sweating, tremor, chest pain, nausea, chills/hot flushes apprehension increased vigilance sleeping difficulties ```
50
How do you treat GAD?
conservative - individual self-help/self-help groups, CBT, applied relaxation therapy Medical - SSRIs or SNRIs, pregabalin, benzos, beta-blockers like propranolol for physical symptoms
51
What are the symptoms of panic disorder?
physical - tachycardia, palpitations, sweating, dizziness, choking psychological - feel like they're going to die, impending doom, depersonalisation, derealisation, fear of losing control
52
What are the risk factors for OCD?
genetics - FHx of OCD or tic disorder parental over-protection may occur after strep infection - PANDAS subtype - paediatric neuropsychiatric disorders associated with streptococci
53
How does OCD present?
``` time consuming (>1hr/day) bsessions and/or compulsions present most days for at least 2 weeks distressing and interfering with ADLs avoidance of the stimuli that trigger the symptoms ```
54
How is OCD treated?
psychoeducation CBT - exposure followed by response prevention meds - SSRIs
55
What is a somatisation disorder?
Physical symptoms without physical explanation persistent for at least 2 yrs more common in women usually GI and skin complaints massive impact on daily functioning often results in multiple needless operations as they refuse to believe that there is no organic cause tx - excluding all organic illness
56
What is a conversion disorder?
presents with neurological SIGNS (rather than symptoms) e.g. paralysis, weakness, amnesia btu the examination is inconsistent pt is not faking it consciously no evidence of underlying pathology
57
How much is a unit of alcohol?
10 ml or 8g
58
What are the signs of alcohol dependence?
CAN'T STOP ``` Compulsion to drink alcohol Aware of harms but persists Neglect of other activities Tolerance to alcohol Stopping causes withdrawal Time preoccupied with alcohol Out of control use Persistence, futile wish to cut down ```
59
How to treat alcohol dependence?
1. acute detoxification 2. motivational interviewing 3. psychological therapies 4. self-help groups 5. medication 6. relapse prevention measures
60
What medical treatments can be used to treat alcohol dependence?
Disulfram - blocks alcohol metabolism resulting in flushing, headaches, anxiety and nausea Acamprosate - acts on GABA to reduce cravings and risk of relapse Naltrexone - opioid receptor antagonist
61
What are the stages of change steps?
1. pre-contemplation 2. contemplation 3. planning/preparation 4. action 5. maintenance 6. sustained maintenance or potential for relapse
62
What is delirium tremens?
An acute confusional state secondary to alcohol withdrawal - medical emergency requiring inpatient care
63
How quickly does DT occur after last drink?
1-7 days | peak incidence at 48-72 hours
64
How does dellirirum tremens present?
``` clouding of consciousness disorientation amnesia for recent events psychomotor agitation tremors visual, auditory and tactile hallucinations (characteristically of small people or animals) fluctuations in severity risk of cardiovascular collapse, paranoid delusions/fear, confabulation and heavy sweating ```
65
How do you treat delirium tremens?
thiamine (pabrinex) lorazepam antipsychotics - haloperidol, olanzapine
66
What is Korsakoff's psychosis?
short term memory loss and confabulation occurs in heavy drinkers due to thiamine deficiency thiamine deficiency causes damage and haemorrhage to the mamillary bodies of the hypothalamus and the medial thalamus
67
What else can Korsakoff's (other than alcohol abuse)?
``` head injury post-anaesthesia basal/temporal lobe encephalitis carbon monoxide poisoning other causes of B1 deficiency - anorexia, starvation, hyperemesis ```
68
What is Wernicke's encepalopathy?
Triad of: 1. confusion/intellectual impairment 2. ataxia 3. ophthalmoplegia (eye muscle paralysis) and nystagmus due to thiamine deficiency
69
How do you treat Wernicke's?
IV pabrinex (high potency thiamine replacement)
70
Name some endocrine disorders that can cause depression.
``` hypothyroid primary hypoparathyroidism hypercortisolaemia (iatrogenic - steroids) hypocortisolaemia - Addison's hypopituitarism ```
71
What are the symptoms of anorexia nervosa?
``` Preoccupation with food self-conscious about eating in public vigorous exercise constipation cold intolerance depressive and compulsive symptoms binging/purging or extreme restriction subtypes ```
72
Name some physical signs seen in someone with anorexia nervosa.
BMI <17.5 emaciation dry and yellow skin peach fuzz hair on face and trunk (lanugo hair) bradycardia and hypotension anaemia consequences of repeated vomiting - hypokalaemia, alkalosis, pitted teeth, parotid swelling, sarring of the dorsum of the hand (Russel's sign)
73
What medications can you use to treat insomnia?
Z drugs - zopiclone, zolpidem, zapeplon (first-line) sedating antidepressants - mirtazapine sedating antipsychotics - quetiapine melatonin
74
What is paraphrenia?
late-onset schizophrenia, after age 45 | less emotional blunting and personality decline compared to younger onset
75
What are the clinical features of paraphrenia?
delusions and hallucinations - esp about neighbours paranoid - often about neighbours partition delusion - patient believes that people or objects can go trough walls less negative symptoms (blunting/apathy) and formal thought disorder compared to early onset
76
What are the risk factors for late onset schizophrenia?
social isolation sensory deficits - poor eyesight/hearing reclusive and suspicious pre-morbid personality more common in women
77
What is Cottard's syndrome?
a belief that everything inside them is rotting/they're already dead inside seen in spychotic depression
78
What is Charles-Bonnet syndrome?
complex visual hallucinations in a person with partial or severe blindness - macular degeneration, diabetic retinopathy patients understand that the hallucinations are not real and often have insight
79
What are some signs to look out for in a person with Munchausen's syndrome?
Already diagnosed with personality disorder usually physical symptomology multiple A&E presentations to several different hospitals frequent admissions often multiple surgical procedures multiple aliases, no fixed address of regular GP when discovered - discharge themselves against medical advice
80
Name some examples of learning disabilities.
``` Down's syndrome Autism specturm disorder and Asperger's syndrome Williams syndrome Fragile X syndrome Global developmental delay cerebral palsy ```
81
What is the triad of symptoms for autism spectrum disorder?
1. impaired social interaction 2. speech and language disorder 3. imposition of routines - ritualistic and repeptitive behaviour
82
What are the main symptoms of ADHD?
inattention hyperactivity impulsiveness restlessness poor concentration
83
How do you treat ADHD?
methylphenidate (Ritalin) - monitor growth psychotherapy
84
What are the cluster A personality disorders? (mad)
paranoid schizoid schizotypal
85
What are the cluster B personality disorders? (bad)
Emotionally unstable Histrionic Narcissistic Antisocial
86
What are the cluster C personality disorders? (sad)
avoidant anxious dependent obsessive compulsive/anankastic
87
Define paranoid PD and list some of its features.
Definition = pervasive and unwarranted tendency to interpret the actions of others as demeaning or threatening - think the world is a conspiracy - thinks people are devious - acts as if always on guard, suspicious - commonest behaviour - watchfulness - least likely to be trusting - emotional hot-spot - being discirminated against THINK MAD-EYE MOODY
88
Define schizoid PD and list some of its features.
Definition = pervasive pattern of indifference to social relationships and a restricted range of emotional expereince and expression - thinks the world is uncaring - thinks poeple are pointless, replaceable - thinks they are the only person they can depend on - commonest behaviour - withdrawal - least likely to be emotionally available and close - emotional hotspot - being over-cared for and smothered by others THINK SEVERUS SNAPE
89
Define schizotypal PD.
pervasive pattern of deficits in interpersonal relatedness and pecularities of ideation, experience, appearance and behaviour. THINK LUNA LOVEGOOD
90
Define emotionally unstable/borderline PD and list some of its features.
Definition = pervasive pattern of instability of mood, interpersonal relationships and self-image. - thinks the world is contradictory - thinks people are untrustworthy - ashamed of themselves commonest behaviour - self-harm - least likely to be able to show self-compassion - emotional hotspot - abandonnment
91
Define histrionic PD and list some of its features.
Definition = pervasive pattern of excessive emotionality and attention seeking. - thinks the world is their audience - thinks people are in competition for attention - thinks they are vivacious (attractively lively and animated) - commonest behaviour - exhibitionism - least likely to be able to listen to others - emotional hotspot - being actively or passively side-lined
92
Define narcissistic PD an list some of its features.
Definition = pervasive pattern of grandiosity, lack of empathy and hypersensitivity to the evaluation of others - thinks the world is a competition - thinks people are inferior - thinks they are special - commonest behaviour - competitveness - least likely to be humble - emotional hotspot - loss of face/social rank/social status/being embarrassed
93
Define antisocial PD and list some of its features.
psychopath - when they get into trouble with the law. Sociopath - same features without problems with the law Definition = childhood conduct disorder before the age of 15 and a pattern of irresponsible and antisocial behaviour post 15 years - thinks the wolr dis predatory - thinks people are weak - thinks of themselves as autonomous and alone - commonest behavioural approach - crushing - least likely to be gentle and sensitive - emotional hotspot - perceiving exploitation
94
Define avoidant/anxious PD and list some of its features.
Definition = pervasive pattern of social discomfort, fear of negative evaluation and timidity - thinks the world is evaluative - thinks people are judgemental - thinks they are inept - commonest behaviour - inhibition - least likely to be assertive - emotional hotspot - exposed ridicule or rejection
95
Define dependent PD and list some of its features.
Definition = pervasive pattern of dependent and submissive behaviour - thinks the world is overwhelming - thinks people are stronger and more competent than themselves - they are needy - commonest behaviour - clinging - least likely to be self-sufficient emotional hotspot - making a decision
96
Define anankastic/obsessive compulsive PD and list some of its features.
Definition = pervasive pattern of perfectionism and inflexibility - thinks the world is sloppy - thinsk people are irresponsible - thinks they are responsible - commonest behaviour - control - least likely to be flexible - emotional hotspot - making a mistake
97
What is adjustment disorder?
An abnormal and excessive reaction to an identifiable life stressor.
98
What are the main symptoms of PTSD?
1. re-experiencing - flashbacks, nightmares 2. avoidance - avoiding people, situations or circumstances resembling the traumatic event 3. hyperarousal - hypervigilance for threat, startles easily, struggles to sleep 4. emotional numbing
99
What signs would you see in someone intoxicated with heroin?
``` euphoria pinpoint pupils drowsiness constipation respiratory depression ```
100
What signs would you see in someone withdrawing from heroin?
``` goose flesh (piloerection) pupil dilation yawning sweating abdo cramps insomnia ```
101
What is the role of section 2 of the MHA?
compulsory admission to hospital for assessment
102
What is the duration for a section 2?
28 days
103
What is the purpose of section 3 of the MHA?
compulsory admission to hospital for treatment
104
What is the duration of section 3?
6 months
105
Can section 2 be renewed?
no
106
Can section 3 be renewed?
yes
107
What is the purpose of section 4 of the MHA?
emergency order | when waiting for a second doctor would lead to undesirable delay
108
What is the duration of a section 4?
72 hours
109
What is the purpose of a section 5(4)?
for a patient ALREADY admitted but wanting to leave
110
Who can hold a patient on a section 5(4)?
nurses this is their holding power until a doctor can attend
111
How long does a section 5(4) last?
6 hours
112
What is a section 5(2)?
For a patient ALREADY admitted to hospital but wanting to leave
113
Who can implement a section 5(2) and how long does it last?
Doctors 72 hours doctor's holding power - gives time for section 2 or 3 to be put in place. Has to be a doctor on that specific ward, cannot be done in A&E
114
Which sections can be put in place by the police?
Section 135 and 136 136 - suspicion of having a mental disorder in a public place 135 - needs court order to acccess patient's home and remove them
115
What is neuroleptic malignant syndrome and what are some of its features?
Psychiatric emergency caused by excess of enuroleptic medicaion or acute wthdrawal from Parkinson's medication. ``` onset over hours or days hyperpyrexia hyporeflexia sweating normal pupils tachycardia rigidity rasied CK ```
116
How to manage NMS?
``` stop the offending agent or give L-dopa in dopamine withdrawal IV fluids Benzos bromocriptine dantrolene ``` dantrolene is also used to prevent and treat malignant hyperthermia
117
What is serotonin syndrome?
Caused by SSRIs, MAOIs, Ecstacy, Amphetamines (cocaine, mcat), antiemetics (metoclopramide), St John's Wort
118
What are the features of serotonin syndrome?
``` onset over minutes/hours hyperthermia/hyperpyrexia sweating hyperreflexia clonus rigidity altered mental state dilated pupils ```
119
How to manage serotonin syndrome?
IV fluids Benzos stop the offending agent
120
What is the revised dopamine hypothesis for schizophrenia?
positive symptoms are caused by dopamine overactivity in the mesolimbic system. negative symptoms are cuased by dopamine underactivity in the mesocortical system.
121
What is Clerambault's syndrome?
erotomania young woman believes man of higher status is secretly in love with her and is sending her secret messages
122
What is Othello syndrome?
pthological jealousy - high risk of abuse and violence