Psych Flashcards
What are the core symptoms of depression?
- Low mood
- Loss of energy (anergia)
- Anhedonia - loss of enjoyment of formerly pleasurable activities
Name some other symptoms of depression.
Early morning wakening change in appetitie change in sex drive diurnal variation of mood - lowest in morning agitation loss of confidence loss of concentration guilt hopelessness suicidal ideation
What is the ICD10 diagnostic criteria for clinical depression?
At least 2 of the 3 core symptoms
present every day
for at least 2 weeks
What are some risk factors for depression?
Family hx hx of abuse drug and alcohol abuse low socioeconomic status having a chronic disease traumatic life event
What are some medical causes for depression?
hypothyroidism
physical health problems/chronic disease
medications - isoretinoin (roccutane), beta blockers
childbirth
What are some non-medical treatments for depression?
self-help groups
guided self help
computerised CBT
individualised CBT or onterpersonal therapy
psycholoigcal therapy with antidepressants
What are some medical treatments for depression?
antidepressants - continue for at least 6 months after symptoms stop
resistant depression = antidepressants + lithium/atypical antipyschotic/another antidepressant
ECT
Name some classes of antidepressants, give examples of drugs within them.
SSRIs - sertraline, citalopram, fluoxetine
SNRIs - venlafaxin, duloxetine
inhibits 5HT reuptake pumps and NAd transporter
MAOIs - isocarboxazid, seligiline - can lead to hypertensive crisis and can cause migraine
TCAs - amitryptyline
What are some side effects of SSRIs?
GI symptoms sexual impotence weight gain increased bowel motility agitation increased risk of GI bleed if taking NSAID so give PPI
Which drugs do SSRIs interact with?
NSAIDs - add PPI if giving SSRI
Warfarin/heparin - avoid SSRI, consider mirtazapine (SNRI)
Aspirin - give PPI
Triptans - avoid SSRI
NB: fluoxetine and paroxetine have higher risk of interaction
Which SSRI is given first line in children and adolescents?
Fluoxetine
Which SSRI is given first line for generalised anxiety disorder?
Setraline
What are some discontinuation symptoms of SSRIs?
incresed mood change restlessness difficulty sleeping unsteadiness sweating GI symptoms - pain, cramping, diarrhoes, vomiting paraesthesia
What are some side effecs of tricyclic antidepressants?
urinary retention - anticholinergic effects
Dry mouth
lethargy/drowsiness
constipation
Name some risk factors for suicide following self harm.
single
homeless
unemployed/stressful job
poor social support
type of self harm - superficial vs deep cuts
whether they regret the self harm or express the desire t do it again
Define bipolar affective disorder.
recurrent episodes of altered mood and activity
involving both upswings and downswings (hypomania/mania + depression)
What’s the difference between bipolar 1 and 2?
Bipolar 1 - mania + depression, sometimes more episodes of mania
Bipolar 2 - more episodes of depression and only mild hypomania
Cyclothymia - chronic mood fluctuations over at least 2 years. Episodes of depression and hypomania Rapid cycling, episodes only last a few days.
What are the risk factors for bipolar disorder?
strong genetic component
traumatic life event
hx of abuse
sleep deprivation can cause mania
What is the peak age of onset of bipolar disorder?
Early 20s
What are the symptoms of hypomania?
Lasting at least 4 days -
elevated mood increased energy increased talktativeness poor concentration mild reckless behaviour (overspending) overfamliarity increased libido/sexual disinhibition increased confidence decreased need to sleep change in appetitie
What are the symptoms of mania?
Lasting over 1 week and more extreme than hypomania -
extreme, uncontrollable elation overactivity pressured speech impaired judgement extreme risk taking behaviour social disinhibition inflated self-esteem, grandiosity mood congruent psychotic symptoms insight is often absent
What is the main feature that differentiates mania from hypomania?
presence of psychotic symptoms such as auditory hallucinations and grandiose delusions
What are some differential diagnoses for bipolar disorder?
substance abuse - amphetamines, cocaine
endocrine disease - Cushing’s, steorid-induced psychosis
schizophrenia
schizoaffective disorder
personality disorders - EUPD, histrionic
ADHD in younger people
How do you treat an episode of acute mania?
antipsychotics - haloperidol, olanzapine, quetipine, risperidone
lithium
Benzos for acute behavioural disturbance