Psych Flashcards
Antidepressant used after MI/ Coronoary heart disease
Sertraline
Antidepressant causing Long QT
Citalopram
Antidepressant with long half life (so no withdrawal)
Fluxoetiene
Rapid tranquillisation drugs
IM Lorazepam, Haloperidol
Clozapine Use
Treatment resistant Schizophrenia
Definition of Treatment resistant depression
failure to respond to 2 or more antipsychotics (1 of which is atypical) @theraputic dose for more than 6 weeks
Emergency side effect with Clozapine and how to prevent
Angranulocytosis - occurs in 0.7%
Weekly blood test to look for neutropenia
What is dystonia? What causes it
Involuntary, painful, sustained muscle spasms
onset within hours
Neck twist - torticollis
eyes twist up and can’t look down - oculogyric crisis
Extra-pyrimidal side effects (EPSE)
with typical antipsychotics
How do you treat dystonia
IM Procylidine/Benztropine (Anti-CHolinergic
What is Akathsia
Unpleasant subjective restlessness e/g leg jiggling
EPSE
How do you treat akathisia
Propanolol
What is Tardive Dyskinesia
Rhythmic involuntary movements e.g grimacing –> often irreversible
How do you treat Tardive Dyskinesia
Stop antipsychotics or change to atypical
Tetrabenazine
DON”T USE ANTICHOLINERGICS
What drugs cause Hyperprolactianemia and what does that cause
Typical antipsychotics
Amenorrhoea, gynaecomastia, hypogonadism, sexual dysfunction, osteoporosis risk
Schizophrenia first rank symptoms
Delusional perceptions
Passivitiy –> believing that things are being controlled e/g movements
Thought interference - Withdrawal, insertion, broadcast
Auditory Hallucinations –> thought echo or 3rd person
What is Hebephrenic Schizophrenia
Disorganised and chaotic mood/behaviour/speech
Often Childish
Less delusions and hallucinations
What is posturing and what do you get it with
Maintain bizzarre positions
Catatonic schizo
What is waxy flexibility
Can put them in weird positions and they’ll hold
Catatonic schizo
What is perserveration
Inappropriate repetition of words/actions
Catatonic scizo
What is rigidity
They won’t move when you try to move them
Catatonic schizo
4 key features of PTSD
Intrusive symptoms/re-experiencing
Avoidance
Hyperarousal
Emotional deficits e.g detachment
4 treatments of PTSD
CBT
Eye movement desensitisation and reprocessing
SSRI/SNRI
Support groups
Adjustment disorder trigger and length
Prolonged severe abnormal response to a stressful life event (e.g divorce) beginning within. 1 month and lasting no more than 6m
Symptoms of anxiety
How long should a manic episode last
1 week
A patient is hyperaroused but is able to go to work - is this mania or hypomania
Hypomania –> mania requires disruption to day to day life
MZ% of depression
44%
DZ% of depression
20%
Lifetime risk of schizo
1%
How long does it take SSRIs to work
4-6w
Which class of antidepressants are cardiotoxic in overdose
TCAs
Name some side effects of SSRIs
Initial suicidal ideation Sexual dysfunction Drowsiness (esp with ETOH) Decreased seizure threshold Hyponatraemia N&V Blurred vision Anxiety Sweating tremor Persistent pulmonary hypertension in the newborn
Which drugs are most often implicated in serotonin syndrome
MAO-I
Which drugs cause the cheese reaction with tyramine rich foods
MAOI- cheese reaction
When would you use ECT in depression
Psychotic or v severe irretractible depression (affecting things like eating and drinking
How long should depressive symptoms last
2w
3 key depressive symptoms
Anergia
Anhendonia
Low mood
MZ risk of BPAD
80%
DZ risk of BPAD
20%
Risk with first degree relative
8%
Type 2 BPAD
Mainly depression w/ hypomania
Type 1 BPAD
Mania w/ depression
Rapid cyclic BPAD
4 or more episodes a year
Treatment for Rapid Cyclic BPAD
Sodium Valproate
Lithium Overdose
GI disturbances, ataxia, tremor, fit, renal failure, slurred speech, arythmia
Can you use Sodium Valproate in pregnancy
NO - give folate and contraception advice
What anomaly does Lithium cause in pregnancy
Ebstein’s anomaly - Atrialisaiton of the right heart, tricuspid
valve moves down, right to left shunt thru ASD/PFO
Should you give antidepressants in BPAD
Only with a mood stabiliser as can trigger mania
MZ for schizo
Around 50%
DZ for schizo
4%
1º relative for schizo risk
10%
How long should anxiety symptoms last for diagnosis
6m
What is Wernicke’s encephalopathy + Cause
Thiamine deficiency
Causes Ataxia, confusion and eye problems (ophthalmoplegia & nystagmus)
What is Korsakoff’s syndrome
Irreversible anterograde amnesia - can’t remember new events
Will confabulate to fill in the gaps
Questionaire for alcohol
CAGE -
Have you ever felt you needed to Cut down on your drinking?
Have people Annoyed you by criticizing your drinking?
Have you ever felt Guilty about drinking?
Have you ever felt you needed a drink first thing in the morning (Eye-opener) to steady your nerves or to get rid of a hangover?