Psych Flashcards

1
Q

[Psychotic Disorders]

  1. Delusions and types
  2. Illusions vs hallucinations and types
A
  1. Delusions - fixed, false beliefs against cultural norms and despite evidence to the contrary
    - persecutory - most common
    - ideas of reference - external stimuli perceived as personal (Eg actor on TV winking at you)
    - delusions of control – thought broadcasting, thought insertion
    - delusions of grandeur - special powers
    - delusions of guilt
    - somatic delusions - disease or illness
  2. Illusions vs hallucinations
    A. Illusions - misinterpretation of existing stimulus
    B. Hallucinations- sensory perception without existing stimulus
    - auditory - schizo
    - visual - delirium, drugs, alcohol withdrawal
    - olfactory - epilepsy
    - tactile - drug use, alcohol withdrawal
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2
Q

[Psychotic Disorders]
Schizophrenia
1. Types of symptoms
2. Criteria for diagnosis

A
Schizophrenia 
1. Types of symptoms
A. Positive 
- delusions 
- hallucinations
- disorganized speech e.g. looseness of association, clanging, flight of idea, neologisms
- disorganized behavior e.g. catatonia

B. Negative *most impairment to QOL, most difficult to treat

  • apathy / avolition
  • anhedonia
  • affect (flat)
  • alogia
  • attention - decreased

C. Cognitive - decreased executive function and working memory
- decreased size of hippocampus and amygdala

  1. Criteria for diagnosis - 2+ symptoms (1 must be either delusions, hallucinations, or disorganized speech) for >1 months
    - total duration >6 months
    - course includes prodromal (decreased functioning), psychotic, and residual (more neg sx)
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3
Q

[Psychotic Disorders]
Schizophrenia
3. Pathophysiology via tracts (mesolimbic, mesocotical, nigrostriatal, tubuloinfundibular) and neurotransmitters
4. CT scans

A

Schizophrenia

  1. Pathophysiology
    - ↑ dopamine in mesolimbic tract –> psychotic sx
    - ↓ dopamine in mesocortical tract (frontal cortex) –> negative sx, poor cognition
    - nigrostriatal tract - blocked by antipsychotics –> EPS
    - tubuloinfundibular tract - blocked by antipsychotics esp typicals and risperidone –> hyperprolactinemia –> gynecomastia, galactorrhea, sexual dysfunction, menstrual irregularities
  • also ↑ serotonin (atypicals also antagonize 5HT)
  • ↑ norepi (long-term antipsychotic use decreases norepi levels)
  • ↓ GABA (which has regulatory effect on dopamine) in hippocampus
  • ↓ glutamate - fewer NMDA receptors *why ketamine (NMDA antagonist) causes psych sx
  1. CT shows enlarged ventricles, cortical atrophy, and decreased brain volume
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4
Q

[Psychotic Disorders]
Schizophrenia
5. Compare contrast with schizophreniform disorder, brief psychotic disorder

A

Schizophreniform - symptoms between 1 and 6 months
- 1/3 recover, 2/3 progress to schizophrenia or schizoaffective
tx - 6 months course of antipsychotics, supportive psychotherapy

Brief psychotic disorder - symptoms between 1 day and 1 month, eventual full return to level of functioning

  • positive symptoms only (delusions, hallucinations, disorganized speech/ behavior)
  • tx - antipsychotics, benzos, supportive psychotherapy

*borderline personality may have transient, stress-related psychotic symptoms but this is not brief psychotic disorder, it’s attributed to their underlying personality disorder

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5
Q
[Psychotic Disorders]
Delusional disorder
1. Criteria
2. Types
3. Treatment
A

Delusional disorder - more common after age 40

  1. Criteria - 1+ delusions for >1 month
    - does not meet criteria for schizophrenia
    - no bizarre behavior, functioning not impaired
    - usually non-bizarre delusions
  2. Types
    - erotomanic
    - grandiose
    - somatic
    - persecutory *most common
    - jealous
    - mixed
    - unspecified
  3. Treatment - difficult to treat given lack of insight and impairment
    - antipsychotics
    - supportive therapy but NO groups
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6
Q
[Psychotic Disorders]
Culture-specific psychoses
1. Koro
2. Amok
3. Brain fag
A
  1. Koro - anxiety that penis will recede into body, leading to death – in southeast asia (singapore)
  2. Amok - sudden, unprovoked outbursts violence followed by suicide - in malaysia
  3. Brain fag - headache, eye pain, fatigue, cognitive difficulties in male students - in Africa
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7
Q

[Psychotic Disorders]

Differentiate mood disorder with psychotic features from schizoaffective disorder

A

Schizoaffective - meet criteria for either major depressive or manic episode during which psychotic symptoms are also present

  • but also - delusions or hallucinations for 2 weeks in absence of mood disorder symptoms
  • mood sx present for majority of psychotic illness

Mood disorder with psychotic features – better prognosis, hallucinations and/or delusions present ONLY during depressive or manic episodes

  • usually mood congruent e.g. depression –> paranoia, mania –> grandiosity, invincibility
  • treat MDD w psychosis –> antidepressant and antipsychotic or ECT
  • remember that bipolar I may have psychotic features that occur during depressive OR manic episodes
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8
Q

[Mood Disorders]

  1. Depressive episode criteria
  2. Manic criteria
  3. Hypomanic criteria
  4. Mixed features
A
  1. Depressive episode criteria - 5 symptoms for 2+ weeks
    - depressed / sad mood + 4 SIGECAPS
    - anhedonia (loss of interest) + 4 add’l SIGECAPS
    SIGECAPS: sleep, interest, guilt/worthlessness, energy/fatigue, concentration, appetite, psychomotor activity (restlessness or slowness), SI
  2. Manic criteria - at least 3 symptoms for 1+ week or until hospitalized
    - abnormally elevated or irritable mood (if irritable, need 4 symptoms)
    DIGFAST - distractibility, insomnia/impulsive behavior, grandiosity, flight of ideas/racing thoughts, activity/agitation, speech (pressured), thoughtlessness
    *50% have psychotic features
  3. Hypomanic criteria - no marked impairment in functioning only psych disorder where this is true
    - no psychotic features
    - at least 3 symptoms for 4+ days (4 sx if mood is irritable)
  4. Mixed features - meet criteria for manic or hypomanic episode and 3+ symptoms of major depressive episode are present for 1+ week
    - predominant mood state is irritability
    * poorer response to lithium –> give valproic acid
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9
Q

[Mood Disorders]
Medical and substance/medication causes of
1. Depressive episode

A
  1. Depressive episode
    A. Medical -
    - cardiovascular (stroke, MI)
    - endocrinopathies (DM, Cushing, Addison, hypoglycemia, thyroid, calcium)
    - other - Parkinsons, mono, Carcinoid, SLE
    - cancer (lymphoma, pancreatic)

B. Medications

  • alcohol
  • barbiturates and other sedative hypnotics
  • corticosteroids + levodopa (can also cause mania)
  • antipsychotics
  • anticonvulsants
  • beta blockers
  • diuretics
  • sulfonamides
  • withdrawal from stimulants (cocaine, amphetamines)
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10
Q

[Mood Disorders]
Medical and substance/medication causes of
2. Manic episode

A
2. Manic episode
A. Medical 
- metabolic (hyperthyroid) 
- neuro (MS, temporal lobe seizures) 
- HIV

B. Medications –> bipolar

  • antidepressants
  • sympathomimetics
  • dopamine
  • corticosteroids (can also cause depression)
  • levodopa (can also cause depression)
  • bronchodilators
  • cocaine
  • amphetamines
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11
Q
[Mood Disorders]
Major depressive disorder (MDD)
1. Criteria
2. Sleep problems
3. Etiology
4. Treatment
A

Major depressive disorder
1. Criteria - at least one major depressive episode, no hx of mania/hypomania

  1. Sleep problems
    - multiple awakenings
    - initial and terminal insomnia (hard to fall asleep, early morning awakening) most common problems
    - decreased REM sleep latency, earlier cycles and longer duration
    - decreased slow wave (3 and 4) sleep
  2. Etiology - neurotransmitters (Decreased serotonin, 5HIAA - main 5HT metabolite- in CSF)
    - HPA axis hyperactivity –> increased cortisol
    - abnormal thyroid axis
    - multiple adverse childhood events eg loss of parent
    - genetics
  3. Treatment - CBT and SSRI, try for 6- 8 weeks before another SNRI/SSRI, then another MOA (bupropion, mirtazapine)
    - continuation phase tx - continue antidepressants for addl 6 months with single episode, unipolar major depression
    - maintenance tx - 1-3 years for history of recurrent MDD, -
    chronic (>2 years), family hx, or severe episodes
    maintenance tx indefinitely - history of highly recurrent or very severe chronic MDD episodes
    - hospitalization if risk for SI/HI, can’t take care of themself
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12
Q
[Mood Disorders]
Describe ECT 
1. Indications
2. Contraindications
3. Procedure
4. Side effects
A

Electroconvulsive therapy

  1. Indications
    - MDD - treatment resistant or w psychotic features
    - acute mania
    - pregnant
    - emergency conditions (not eating/drinking, catatonic, actively suicidal)
  2. Contraindications - none!
    - relative c/i: recent MI or stroke, space-occupying brain lesion, unstably aneurysm
  3. Procedure
    - atropine, then general anesthesia with methohexital, then muscle relaxant succinylcholine
    - induce generalized tonic clonic seizure for 30-60 sec
    - 12 treatments over 3 week period or so
    - d/c after symptomatic improvement, but can have monthly maintenance ECT
  4. Side effects
    - retrograde and anterograde amnesia, resolves within 6 months
    - also headache, nausea, muscle soreness

*1st line tx for MDD w psychotic features = ECT or antipsychotic + antidepressant

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13
Q
[Mood Disorders]
Major depressive disorder 
Specifiers  -
1. Atypical 
2. Melancholic
3. Mixed
4. Catatonia
5. Psychotic
6. Anxious distress
7. Postpartum
8. Seasonal
A
  1. Atypical - hypersomnia, hyperphagia, reactive mood (mood brightens in response to positive events), leaden paralysis, hypersensitivity to interpersonal rejection
  2. Melancholic - anhedonia, depression worse in AM, anorexia, excessive guilt
  3. Mixed - manic/hypomanic symptoms present during major depressive episode
  4. Catatonia - catalepsy (immobility), mutism, bizarre postures, echolalia; give ECT or benzos (lorazepam challenge test –> temporary relief w/in 10 min)
  5. Psychotic - delusions/hallucinations
  6. Anxious distress - restless, fearful, feeling of loss of control
  7. Postpartum - during or within 4 weeks of pregnancy (as opposed to postpartum blues - which resolves w/in 2 weeks)
    * give sertraline bc lowest transfer rate to infant
  8. Seasonal - irritability, carb craving, and hypersomnia
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14
Q
[Mood Disorders]
Bipolar I 
1. Criteria 
2. Etiology
3. Treatment
A

Bipolar 1

  1. Criteria - manic episode is only requirement (3+ DIGFAST symptoms for at least one week)
    - do not need major depressive episode
    - can have psychotic features (delusions/hallucinations)
  2. Etiology - M=F, onset before 30
    - highest genetic link of all major psychiatric disorders
    - high suicide risk
    - 90% have repeat episode w/in 5 years
  3. Treatment - untreated –> lasts months
    - pharmacotherapy -
    * mood stabilizer (e.g. lithium)
    * anticonvulsants (Carbamazepine, valproic acid)
    * atypical antipsychotics (for acute mania; use for 6 weeks until Lithium kicks in)
    * do NOT give antidepressants, may precipitate mania
  • bipolar depression – quetiapine, lurasidone, lamotrigine
  • psychotherapy
  • ECT for acute mania
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15
Q
[Mood Disorders]
Bipolar II
1. Criteria 
2. Etiology
3. Treatment
A

Bipolar II

  1. Criteria - 1+ major depressive episodes and at least one hypomanic episode
    * if there is any full manic episode –> automatically bipolar I disorder
  2. Etiology - same etiology as bipolar I
    - better prognosis than bipolar I
  3. Treatment - same as bipolar I
    - bipolar depression – quetiapine, lurasidone, lamotrigine
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16
Q

[Mood Disorder]
Criteria for:
1. Dysthymia
2. Cyclothymic disorder

A
  1. Dysthymia
    - at least 2 years of depressed mood (1 year in children)
    - at least 2 of the following: poor concentration, hopelessness, poor or too much appetite, insomnia/hypersomnia, fatigue, low self-esteem
    - never asymptomatic for >2 months
    - many also meet criteria for MDD but can not have had manic/hypomanic episode (bipolar/cyclothymic respectively)
  2. Cyclothymic disorder
    - at least two years of alternating hypomanic symptoms (but not full hypomanic episode) and depressive symptoms (but not full MDE)
    - never asymptomatic for >2 months
    - no MDE, hypomanic, or manic episode
    * may coexist with borderline personality disorder
    * 1/3 develop bipolar disorder
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17
Q

[Mood Disorder]
Criteria for:
3. Premenstrual dysphoric disorder
4. Disruptive mood regulation disorder (DMDD)

A
  1. Premenstrual dysphoric disorder
    - 5+ symptoms in the final week before menses and absent by the week postmenses:
    * 1+ is affective lability, irritability, depressed mood, anxiety
    * 1+ is anhedonia, anergia, appetite changes, hypersomnia/insomnia, overwhelmed, physical (breast tenderness, joint pain, bloating, weight gain)
    - symptoms cause distress/impairment
    - treatment: keep menstrual diary, exercise, stress reduction, SSRI (eg fluoxetine)
  2. Disruptive mood regulation disorder (DMDD) - severe, persistent irritability in childhood and adolescence
    - symptoms before age 10, can be diagnosed from ages 6-18
    - 2+ settings (home school peers)
    - at least 3 verbal and/or physical outbursts per week
    - mood bw outbursts is angry/irritable
    - symptoms for at least 1 year, no more than 3 months without symptoms
    * cannot coexist with oppositional defiant disorder, intermittent explosive disorder, or bipolar disorder
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18
Q

Treatment for EPS:

  1. Acute dystonia
  2. Akathisia
  3. Parkinsonism
  4. Tardive dyskinesia
A

EPS - eps with typical antipsychotics (bc of decreased dopamine in nigrostriatal tract)

  1. Acute dystonia (muscle spasms/stiffness, torticollis, oculogyric crisis, grimacing) - hours to days –> treat with anticholinergics (e.g. benztropine, diphenhydramine)
  2. Akathisia (subjective feeling of restlessness) - days to weeks –> Treat with propranolol, benzos (lorazepam), or benztropine and lower antipsychotic dosage (since it is dose-dependent)
  3. Parkinsonism (masklike face, bradykinesia, pill-rolling tremor, cog-wheel rigidity)- days to weeks –> treat with benztropine, amantadine
  4. Tardive dyskinesia - (months to years of prolonged therapy, can also appear following dose discontinuation or reduction)
    - due to D2 receptor upregulation and supersensitivity following chronic blockade
    - irreversible, no definitive treatment, but switch to clozapine may help (least likely to cause EPS), along with Vitamin E or botox

*NMS can occur at any time, usually early on in treatment

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19
Q

[Anxiety Disorders]

  1. Define pathologic anxiety, signs/sx
  2. Substance / medication causes
  3. Medical causes
  4. Treatment
A
  1. Pathologic anxiety - excessive, irrational, out of proportion to trigger or without trigger
    - SOB, chest pain, palpitations, HTN, vertigo, tremors, n/v, stomach pain, diarrhea/constipation
  2. Substance / medication causes
    A. Withdrawal - sedative-hypnotics (benzos, barbs)
    B. Intoxication - marijuana, hallucinogens (PCP, LSD, MDMA), caffeine, opioids
    C. Withdrawal and intoxication - stimulants (cocaine), tobacco
  3. Medical causes -
    - neurologic (brain tumors, MS, HD, epilepsy, migraines)
    - endocrine (carcinoid, pheo, hypoglycemia, hyperthyroid)
    - metabolic (B12 deficiency, porphyria)
    - respiratory (COPD, asthma, PE, pnuemonia)
    - cardiovascular (CHF, arrhythmia, MI)
  4. Treatment
    - first-line - SSRIs, SNRIs
    - also benzos, diphenydramine, hydroxyzine - for prn use
    * benzos may worsen depression in comorbid MDD
    - buspirone (5HT1 partial agonist) - for augmentation
    - beta blockers - to control autonomic sx for panic attacks, performance anxiety
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20
Q

[Anxiety Disorders]
Criteria and treatment for:
1. Panic disorder
2. Generalized anxiety disorder

A
  1. Panic disorder
    A. Criteria - 1+ spontaneous, recurrent panic attacks without trigger followed by 1+ month of continuous worry about experiencing subsequent attacks and/or change in behavior (avoidance)
    - panic attack: Da PANICS (dizziness, disconnectedness, derealization/depersonalization, palpitations/paresthesias, abdominal distress, numbness, intense fear of dying, chills/chest pain, sweating/SOB)
    - comorbid with MDD and other anxiety disorders esp agoraphobia
    - decreased volume of amygdalaa
    B. Treatment - SSRIs and CBT
    - TCAs are second line
    - benzos (lorazepam ie Ativan) for prn or as bridge until long-term meds are effective
    - give propranolol for treating autonomic effects of panic attacks (also performance anxiety or akathisia)
    - screen for suicide risk
    *increased sensitivity to lactate infusion (Causes panic sx)
  2. Generalized anxiety disorder
    A. Criteria - excessive anxiety/worry about various events for at least 6 months with 3+ symptoms: WARTS (wound-up, worn-out, absent-minded, restless, tense, sleepless)
    - comorbid with anxiety/depressive disorders
    - begins ~30 years old
    B. Treatment - CBT, SSRI/SNRI, short-term benzos, augment with buspirone, exercise
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21
Q

[Anxiety Disorders]
Criteria and treatment for:
3. Agoraphobia
4. Phobias / social anxiety disorder

A
  1. Agoraphobia
    A. Criteria - intense fear/anxiety about 2+ situations due to fear of difficulty escaping e.g. bridges, crowds, buses/trains, open areas for >6 months
    - fear/anxiety out of proportion to potential danger posed
    - significant impairment
    - frequently following traumatic event, 50% have panic attack prior to onset
    B. Treatment - CBT and SSRIs
  2. Phobias / social anxiety disorder
    A. Criteria - >6 months irrational fear that leads to avoidance of trigger or endurance of anxiety
    - specific phobia: environmental, animal, situational, blood/injection
    - social anxiety phobia - fear of scrutiny by others or of negative evaluation e.g. public speaking
    *most common psych disorder in women, 2nd MC in men (substance is 1st)
    B. Treatment - behavioral therapy (systematic desensitization) is first line
    - for social anxiety disorder, can give SSRIs (fluoxetine)
    - beta blockers (propranolol) for performance anxiety subtype of social anxiety disorder
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22
Q

[Anxiety Disorders]
Criteria and treatment for:
5. Selective mutism
6. Separation anxiety disorder

A
  1. Selective mutism
    A. Criteria - failure to speak in specific situations, despite speech ability in other situations, for at least 1 month (extending beyond 1st month of school)
    - starts in childhood, suffering from anxiety
    B. Treatment - CBT, family therapy, SSRIs for comorbid social anxiety disorder
  2. Separation anxiety disorder
    A. Criteria - >1 month in children, >6 months in adults developmentally inappropriate fear/anxiety re separation from attachment figures with at least 3:
    - worry about loss of figures
    - reluctance to leave home, be alone, sleep alone
    - physical symptoms when separated
    - nightmares
    *normal devlpt: stranger anxiety (~6-9 mos), separation anxiety (12-18 mos)
    B. Treatment - CBT, family therapy, SSRIs
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23
Q

Triad of uncontrollable urges seen in children or adolescents

A

OCD, ADHD, tic disorder

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24
Q

[Anxiety Disorders]
Criteria and treatment for:
1. OCD

A
  1. OCD
    A. Criteria - obsessions and/or compulsions that are time-consuming (>1 hour/day) or cause significant distress
  • obsessions - intrusive, anxiety-provoking thoughts or urges that the patient attempts to suppress, ignore, or neutralize by performing a compulsion e.g. contamination, harm/doubt, symmetry, intrusive taboo thoughts (sexual, violent)
  • compulsions - repetitive behaviors or mental acts that the patient feels driven to perform e.g. cleaning, checking, ordering/counting

B. Course - mean age of onset 20 years old

  • genetic component
  • suicidal ideation in 50%
  • structural abnormalities and increased activity of orbitofrontal cortex and caudate nucleus (dorsal striatum of the basal ganglia)

C. Treatment - combo of psychopharm + CBT

  • psychopharm - SSRIs at higher doses for longer period (8-12 weeks)
  • can also use clomipramine, augment with atypicals
  • use cingulotomy for treatment resistant
  • CBT - exposure and response prevention
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25
Q

[Anxiety Disorders]
Criteria and treatment for:
2. Body dysmorphic disorder
3. Hoarding disorder

A
  1. Body dysmorphic disorder
    A. Criteria - preoccupation with perceived defects in physical appearance not observable by others that they try to cover up with makeup, derm procedures, plastic surgery
    - repetitive behaviors (grooming, skin picking) or mental acts (comparing appearance) performed in response
    - significant distress or impairment
    - increased prevalence with childhood abuse and neglect
    B. Treatment - SSRIs or CBT to reduces OCD symptoms
  2. Hoarding disorder
    A. Criteria - persistent difficulty and distress discarding possessions, regardless of value
    - impairment in social, occupational other areas of functioning
    - begins in early teens but more prevalent in older pts, 3/4 have comorbid MDD or anxiety
    B. Treatment - specialized CBT, don’t need SSRI unless they also have OCD symptoms
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26
Q

[Anxiety Disorders]
Criteria and treatment for:
4. Trichotillomania
5. Excoriation disorder

A
  1. Trichotillomania
    A. Criteria - recurrent pulling of ones hair, repeated attempts to stop
    - associated with stressful event, onset at puberty
    B. Treatment - SSRIs, atypicals, N-acetylcysteine, lithium
    - CBT (habit reversal training)
  2. Excoriation disorder
    A. Criteria - recurrent skin picking resulting in lesions, repeated attempts to stop
    - mostly women
    B. Treatment - habit reversal training, SSRIs
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27
Q

[Anxiety Disorders]
Criteria and treatment for
6. Acute stress disorder, PTSD

A
  1. Acute stress disorder, PTSD
    A. Criteria
    - recurrent intrusions of reexperiencing event via nightmares, memories, dissociation (e.g. flashbacks)
    - active avoidance of triggering
    - 2+ of the following negative mood: dissociative amnesia (e.g. forgetting info about own life), negative feelings (fear, anger), self-blame, anhedonia, detachment
    - 2+ of increased arousal: hypervigilance, startle, impaired concentration, insomnia

Acute stress disorder - trauma occurred <1 month ago, symptoms last <1 month
PTSD - trauma occurred any time in the past, symptoms last >1 month
- decreased volume of hippocampus

B. Treatment - SSRIs or SNRIs are first line along with trauma-focused CBT (exposure)

  • prazosin for nightmares and paranoia
  • augment with atypicals
  • avoid benzos bc high rate of comorbid substance use disorder
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28
Q

[Anxiety Disorders]
Criteria and treatment for
7. Adjustment disorder

A
  1. Adjustment disorder

A. Criteria - development of marked distress in excess of what would be expected within 3 months of identifiable stressful life event (not life-threatening –> PTSD)

  • resolve within 6 months after stressor has terminated
  • subtypes - depressed mood, anxiety, disturbance of conduct (eg aggression), mixed
  • does not meet criteria for MDD or another disorder

B. Treatment - supportive psychotherapy most effective

  • group therapy, pharmacotherapy
  • may be chronic if stressor is chronic or recurrent
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29
Q

[Personality Disorders]

  1. Criteria
  2. Clusters
  3. Treatment
A

Personality disorders

  1. Criteria - pervasive, inflexible, maladaptive behavior/inner experience that deviates from culture and manifests in 2+ ways:
    * cognition e.g. orphan annie
    * affectivity e.g. john mcenroe
    * interpersonal functioning e.g. elizabeth taylor
    * impulse control e.g. lindsay lohan
    - stable, onset during adolescence / early adulthood –> diagnose after age 18
    - ego-syntonic (pts lack insight)
2. Clusters
Cluster A - Weird
- schizotypal, schizoid, paranoid
Clubster B - Wild 
- borderline, antisocial, histrionic, narcissistic
Cluster C - Worried
- avoidant, dependent, OCPD
  1. Treatment - psychotherapy e.g. CBT except borderline –> DBT
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30
Q

[Personality Disorders]
Cluster A
1. Paranoid

A

Cluster A

  1. Paranoid - pervasive distrust and suspiciousness of others and blame problems on others with 4+ of following:
    - suspicion others are cheating them
    - preoccupation with loyalty
    - reluctance to confide in others
    - holds grudges
    - perception of attacks on character
    - think spouse is cheating on them (pathologically jealous)

defense mechanism –> projection

  • can have transient psychosis under stressful situations
  • avoid group psychotherapy
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31
Q

[Personality Disorders]
Cluster A
2. Schizoid

A
  1. Schizoid - voluntary social withdrawal with 4+ of the following:
    - no desire for close relationships
    - likes solitary activities
    - no interest in sex
    - few if any hobbies, friends, or confidants
    - indifference to praise or criticism
    - flattened affect, detachment, emotional coldness

defense mechanism –> fantasy

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32
Q

[Personality Disorders]
Cluster A
3. Schizotypal

A
  1. Schizotypal - eccentric behavior with 5+ of the following:
    - ideas of reference - external stimuli perceived as personal (Eg actor on TV winking at you)
    - magical thinking (bizarre fantasies, belief in telepathy, superstitions)
    - suspiciousness
    - unusual perceptual experiences
    - odd or eccentric appearance, behavior (cults, strange religious practices)
    - excessive social anxiety
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33
Q

[Personality Disorders]
Cluster B
1. Antisocial

A
  1. Antisocial - violates rights of others since age of 15, must be 18+ to diagnose with 3+ of the following:
    - unlawful acts
    - deceitful, lying, manipulating others for personal gain
    - lack of remorse for actions
    - aggressiveness / repeated fights
    - impulsivity
    - irresponsibility
    - disregard for safety of self or others
    - onset of conduct disorder before 15

defense mechanism –> acting out

  • psychopath
  • more common in men with alcoholic parents
  • psychotherapy ineffective
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34
Q

[Personality Disorders]
Cluster B
2. Borderline

A
  1. Borderline - unstable relationships, affects, and behaviors with 5+ of the following:
    - efforts to avoid abandonment
    - unstable, intense personal relationships (likes bad boys)
    - unstable self-image
    - impulsive (sex, substance use, binge eating, spending)
    - unstable affect / mood reactivity –> rapid mood swings
    - recurrent suicidal threats or attempts
    - feeling of emptiness
    - inappropriate anger
    - paranoid under stress –> brief psychotic episodes

defense mechanism –> splitting

  • F>M, culturally bound (max in USA)
  • pharmacotherapy is most useful here (SSRI and antipsychotics), also DBT (NOT CBT)
  • borderline of neurosis and psychosis
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35
Q

[Personality Disorders]
Cluster B
3. Histrionic

A
  1. Histrionic - excessive emotionality and attention-seeking with 5+ of the following:
    - seductive / provocative
    - center of attention
    - uses physical appearance to get attention
    - theatrical emotions
    - easily influenced by others
    - perceives relationships as more intimate than they really are

defense mechanisms - dissociation, regression

  • generally more functional than borderline
  • countertransference - feel bad for histrionic, mad at narcissistic
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36
Q

[Personality Disorders]
Cluster B
4. Narcissistic

A
  1. Narcissistic - grandiosity, arrogance, and sense of superiority with 5+ of the following:
    - exaggerated sense of self-importance
    - preoccupation with fantasies of success, money
    - belief that they are special and others are not
    - requires admiration / recognition –> get depressed otherwise
    - entitlement
    - takes advantage of others for self-gain
    - lacks empathy
    - envious of others or believes others are envious of him

defense mechanism –> denial

Narcissistic = antisocial (lack of empathy, manipulation) + histrionic (need for admiration)

  • both antisocial and narcissistic exploit others, but latter want status/recognition while former want material gain
  • both histrionic and narcissistic want admiration, but latter make you mad while former make you pity them
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37
Q

[Personality Disorders]
Cluster C
1. Avoidant

A
  1. Avoidant - extreme shyness and intense fear of rejection with 4+ of the following: (AFRAID)
    - avoids occupation with others
    - fear of embarrassment and criticism
    - reserved unless certain of being liked
    - always thinking rejection
    - isolates / cautious of interpersonal relationships
    - distanced / inhibited in new social situations bc of feeling inadequate

defense mechanism –> regression

*similar to social anxiety disorder but that involves fear of embarrassment in particular settings e.g. speaking in public, whereas avoidant is overall fear of rejection, and feeling of inadequacy

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38
Q

[Personality Disorders]
Cluster C
2. Dependent

A
  1. Dependent - fear of separation and clingy behavior with 5+ of the following:
    - difficulty making everyday decisions without reassurance
    - won’t disagree bc of fear of loss of approval
    - needs others to assume responsibilities of life
    - feels helpless when alone
    - urgently seeks relationships
    - preoccupied with fears of having to take care of self
  • usually have one long-lasting dependent relationship, borderline and histrionic are also dependent but unable to maintain long-lasting relationships
  • like histrionic, defense mechanism is regression
  • difficulty with employment since they can’t act independently
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39
Q

[Personality Disorders]
Cluster C
3. OCPD

A
  1. OCPD - preoccupation with perfection and control in variety of contexts with 4+ of the following:
    - preoccupation with details, lists, rules, organization
    - perfectionism detrimental to completion of task
    - excessive devotion to work
    - will not delegate tasks
    - unable to discard worthless objects
    - miserly spending style
    - rigid and stubborn
    - excessive scrupulousness about morals/ethics
  • OCPD is ego-syntonic, OCD is ego-dystonic (aware they have a problem)
  • no mention of obsessions or compulsions in OCPD
40
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
1. Alcohol

A
  1. Alcohol - CNS depressant

A. MOA
- activates GABA, dopamine, and serotonin receptors
- inhibits glutamate receptors, Ca2+ channels
alcohol (alcohol DH)–> Acetaldehyde (aldehyde DH) –> acetic acid

B. Detection - blood/urine testing, stays in blood for few hours; increases MCV and LFTs (AST»ALT)

C. Intoxication - presentation based on BAL
20-50 –> decreased motor control
50-100 –> impaired judgment, coordination
100-150 –> ataxic gait
150-250 –> lethargy, n/v, memory problems
250+ –> respiratory depression, coma

D. Withdrawal - can be lethal

  • 6-24 hours: irritability, insomnia, anxiety, tremor, n/v, autonomic (sweating, tachy, HTN), fever/flushed
  • 12-48 hours: seizures
  • 48-96 hours: delirium tremens (increased RR, HR, BP, visual and tactile hallucinations, agitation, disorientation, tremor and hyperreflexia)
41
Q

[Substance Use Disorders]
Treatment for
1. alcohol withdrawal
2. alcohol use disorder

A
  1. Alcohol withdrawal
    - treat with benzos (chlodiazepoxide, lorazepam) and taper
    - can treat symptoms (Tremor, BP, sweating) with clonidine
    - antipsychotics for severe agitation
    - thiamine, folic acid, multivitamins *correct hypomagnesemia
  2. Alcohol use disorder
    A. naltrexone - opioid receptor blocker that decreases cravings and “high” BUT will precipitate opioid withdrawal in addicted pts
    - can be started while the patient is still drinking
    - c/i in pts with acute hepatitis, liver failure

B. acamprosate - modulates glutamate transmission; used in pts who have stopped drinking –> post-detox for relapse prevention
*can be used in pts with liver disease but c/i in severe renal disease

C. Second-line

  • disulfiram (blocks aldehyde DH enzyme) and causes flushing, n/v, headache –> use in highly motivated patients
  • c/i in pregnancy, cardiac disease, psychosis
  • monitor liver function
  • topiramate (potentiates GABA, inhibits glutamate) - reduces cravings and decreases alcohol use
42
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
2. Cocaine

A
  1. Cocaine - CNS stimulant

A. MOA - blocks reuptake of dopamine, epi, and norepi from synaptic cleft

B. Detection - UDS (+) for 2-4 days

C. Intoxication - euphoria, SNS activation (mydriasis, chills, tremors, sweating / hyperthermia)

  • psychosis due to increased dopa (hallucinations either tactile e.g. formication or visual, paranoia)
  • paradoxical effects - high or low BP, pulse, or psychomotor
  • what can kill you –> MI, intracranial hemorrhage, stroke, arrhythmias, seizures, respiratory depression
  • clinically indistinguishable from panic attack or MI

D. Withdrawal - not life threatening
- acute onset depression “cocaine crash” - constricted pupils, hunger, depression with potential SI, vivid and unpleasant dreams, fatigue

43
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
3. Amphetamines

A
  1. Amphetamines - CNS stimulant

A. MOA

i. Classic - block reuptake, facilitate release of dopamine, norepi from nerve endings e.g. Ritalin (methylphenidate), methamphetamine
ii. Club drugs - release dopa, norepi AND 5-HT from nerve endings e.g. MDMA (Ecstasy) *stimulant and hallucinogen; can lead to serotonin syndrome if combined with SSRIs

B. Detection - UDS (+) for 1-3 days, but MDMA not detected on routine tox screen

C. Intoxication - mydriasis, euphoria, tachycardia, sweating, grinding teeth, skin picking (excoriation), chest pain, dehydration (from dancing in da club), rhabdo/renal failure

  • meth makes you violent, psychotic (paranoid); ecstasy makes you euphoric, social, sexual and gives you bruxism, trismus
  • chronic use –> psychosis, tooth decay (“meth mouth”)

D. Withdrawal - crash with headache, hunger, depression, cravings similar to cocaine

D. Treatment

  • for intoxication – rehydrate, correct hyperthermia
  • supportive for withdrawal
44
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
4. PCP

A
  1. PCP - can be CNS stimulant or depressant depending on dosage

A. MOA - NMDA receptor antagonist, dopamine D2R agonist
- bath salts are similar but PCP has bath salts (eg derealization, dissociation) + stimulant effects (panic attack)

B. UDS (+) up to one week, increased CPK, AST

C. Intoxication

  • nystagmus and mydriasis, ataxia
  • rage / violence and high tolerance to pain
  • hallucinations (visual, tactile), delusions, synesthesia
  • skin dryness / erythema, muscle rigidity
  • OD can cause delirium, seizures, coma, death

D. Treatment

  • lorazepam for agitation, anxiety, muscle spasms, seizures
  • haloperidol for severe agitation, delusions/hallucinations

E. Withdrawal - no withdrawal but you can have flashbacks for a while after, due to release of drug from lipid stores

45
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
5. Sedative-hypnotics

A
  1. Sedative-hypnotics - CNS depressants

A. MOA - potentiate GABA

  • Benzos - increase frequency of GABA opening
  • Barbs - increase duration of GABA opening
  • benzos and barbs are synergistic

B. Detection - in urine/blood for up to 3 weeks for long-acting barbs, up to 4 weeks for long-acting benzos (diazepam)

C. Intoxication - drowsiness, hypotension, slurred speech, ataxia, mood lability, impaired judgment, respiratory depression

  • synergistic with EtOH, opioids (how people die)
  • treatment - (barbs) alkalinize urine with sodium bicarb for renal excretion; (benzos) - flumazenil, but may cause seizures so first thing to do is d/c benzo

D. Withdrawal - life-threatening!! same as alcohol withdrawal, except occur days later than ETOH w/d and not significant increase in BP/pulse

  • early rebound insomnia and increased anxiety
  • treat with benzo taper
46
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
6. Opioids

A
  1. Opioids - oxycodone (oxycontin), Vicodin, Percocet, heroin, codeine, dextromethorphan (higher dose –> glutamate), morphine, meperidine (demerol)

A. MOA - stimulate mu, kappa, delta opiate receptors –> anelgesia, sedation, dependence

B. Detection - UDS (+) for 1-3 days BUT methadone / oxycodone will not show up

C. Intoxication - miosis (except demerol which dilates), constipation, n/v, drowsiness, respiratory depression, seizures

  • demerol, tramadol, MAOIs can cause serotonin syndrome
  • give naloxone

D. Withdrawal - not life-threatening, indistinguishable from the flu –> TGIFRIDAYS:
three sx
GI (n/v)
fever
rhinorrhea/lacrimation
insomnia
dysphoria
arthralgias
yawning
sympathetic arousal (piloerection, sweating, tremor, dilated pupils)
- treat symptomatically with clonidine (can be used for heroin detox), hydroxyzine, NSAIDs, dicyclomine, zofran

E. Treatment

  • methadone (long-acting agonist) - QTc prolongation –> do screening ECG
  • for opiate addicted pregnant women
  • buprenorphine (partial agonist) - safer bc it plateus, comes as Suboxone (adds naloxone)
  • naltrexone (competitive antagonist) - good for highly motivated patients, can precipitate withdrawal w/in 1 week of heroin use
47
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
7. Hallucinogens

*increase BMI with normal waist circumference –> what should you think of?

A
  1. Hallucinogens - shrooms, LSD (acid), peyote

A. MOA - LSD acts on serotonin system –> agonist at 5HT2A receptors

B. Detection - does not show up on tox screens (UDS, blood)

C. Intoxication - depression, anxiety, psychosis

  • perceptual changes (hallucinations/illusions, synthesia), labile affect, dilated pupils, HTN, tachy, tremors, sweating, palpitations
  • bad trip - panic, anxiety, psychotic sx (paranoia)
  • tx - benzos, reassurance

D. Withdrawal - no physical dependence or withdrawal; long-term LSD use can cause spontaneous flashbacks later in life

  • increase BMI with normal waist circumference –> increase muscle mass from anabolic steroids
  • also gynecomastia, testicular atrophy, acne, roid rage
48
Q

[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options:
8. Marijuana

A
  1. Marijuana

A. MOA - THC activates cannabinoid receptors that inhibit adenylate cyclase

B. Detection - UDS (+) 3 days after single use, 4 weeks in long-term users

C. Intoxication - euphoria, anxiety, perceptual disturbances (slowed time), red eyes, cotton mouth, munchies

  • can induce paranoia, hallucinations, delusions
  • chronic use –> asthma, immune suppression

D. Withdrawal - anxiety, restlessness, aggression, strange dreams, depression, sweating, chills, insomnia, decreased appetite
- tx is supportive and symptomatic

49
Q
[Substance Use Disorders]
MOA, Detection, Intoxication, and Withdrawal + treatment options: 
9. Inhalants
10. Caffeine
11. Nicotine
A
  1. Inhalants - CNS depressants e.g. paint thinner, solvents, glue, whippets, nitrous oxide
    A. MOA - N/A
    C. Intoxication - paranoia, perceptual disturbances, dizziness, n/v, headache, neurological sequlae (nystagmus, hyporeflexia), hypoxia, stupor –> quick! lasts 15-30 min
    - long-term use can cause permanent CNS damage (paralysis), myopathy, cancer, myocarditis, etc
    D. Withdrawal - doesnt occur
    *adolescent male whose parents say has been acting bizarrely and hasn’t left his room for months –> nitrous oxide causes erections
  2. Caffeine
    A. MOA - adenosine antagonist –> increased cAMP
    C. Intoxication - anxiety, insomnia, muscle twitching, diuresis, tachycardia
    - OD –> tinnitus, agitation, cardiac arrhythmias, seizures
    *differentiate from cocaine intoxication via facial flushing, GI (diarrhea/cramping); do NOT cause psychosis / aggression (only one along with nicotine that does not)
    D. Withdrawal - headache, fatigue, irritability –> resolves w/in 2 weeks
  3. Nicotine
    A. MOA - stimulates nicotinic receptors in autonomic SNS and PSNS ganglia – dopaminergic
    C. Intoxication - insomnia, anxiety, GI motility
    D. Withdrawal - cravings, anxiety, appetite, irritability
    E. Treatment - varenicline (nAChR agonist) to reduce the high
    - buproprion (inhibits dopa, norepi reuptake) to reduce craving
50
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
1. Delirium

A
  1. Delirium i.e. toxic metabolic encephalopathy, acute organic brain syndrome, acute toxic psychosis

A. Clinical - based on psychomotor activity

i. hypoactive - more common in elderly, presents as depression
ii. hyperactive (ICU psychosis)- agitation, mood lability, due to drug w/d or tox, presents as mania
iii. mixed

B. Diagnosis - decreased attention / awareness of acute onset with fluctuating course (waxing and waning) and disorganized thinking or altered consciousness

  • perceptual disturbances (visual hallucinations)
  • circadian rhythm disturbance
  • do fingerstick, pulseox, ABG, EKG, UDS/UA, CBC/CMP

C. Treatment - treat underlying causes

  • give haloperidol for agitation (decreased risk of anticholinergic side effects)
  • do not give benzos which worsen delirium, except for treating alcohol withdrawal

*ICU triad = delirium, pain, agitation

51
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
2. Alzheimer’s

A
  1. Alzheimer Disease

A. Clinical - insidious onset and subsequent gradual progressive decline in cognitive (memory, learning, language)

  • personality changes, mood swings, paranoia
  • getting lost in familiar places
  • family is more concerned than the patient
  • motor/sensory affected in late stage (death ~10 yrs post diagnosis)

B. Diagnosis -
definitely only postmortem –> extraneuronal Beta amyloid plaques and intraneuronal neurofibrillary tau tangles and progressive widespread cortical atrophy
- decreased ACh
- single gene (APP, presinilin 1 or 2) AD inheritance
- E4 is risk factor, so is Down syndrome

C. Treatment - no cure

  • cholinesterase inhibitors donepezil, rivastigmine, galantamine
  • NMDA receptor antagonist memantine
  • antipsychotics for agitation, but associated with increased mortality
52
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
3. Vascular dementia
4. Parkinsons

A
  1. Vascular dementia
    A. Clinical - stepwise deterioration that affects complex attention and executive functions (planning, decision-making)
    - due to micro-infarcts
    B. Diagnosis - evidence of vascular disease (TIAs, HTN)
    - large vessel strokes (cortical)
    - small vessel strokes (lacunar infarcts to subcortical)
    - microvascular disease (periventricular white matter)
    C. Treatment - manage risk factors to prevent future strokes
  2. Parkinson’s disease - degenerative disorder due to loss of dopaminergic neurons in substantia nigra and alpha-synuclein Lewy bodies
    A. Clinical - TRAP, visual hallucinations, depression, apathy, paranoid delusions
    B. Diagnosis - cognitive decline after motor symptoms
    C. Treatment - carbidopa-levodopa and dopamine agonists
    - reduce dose or give quetiapine or clozapine if psychotic symptoms arise
53
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
5. Lewy Body dementia

A
  1. Lewy Body dementia

A. Clinical - progressive cognitive decline

i. core features
- waxing waning cognition (attention, alertness)
- visual hallucinations (animals, small people) don’t treat if it doesn’t bother patient or caregiver
- devlpt of EPS at least one year after cognitive decline
ii. suggestive features
- REM sleep behavior disorder (violent movements in sleep eg fighting)
- antipsychotic sensitivity *avoid antipsychotics –> increased sensitivity to EPS

B. Diagnosis - definitively only postmortem
- intraneuronal Lewy bodies (alpha synuclein aggregates) in basal ganglia

C. Treatment - no cure

  • cholinesterase inhibitors
  • quetiapine or clozapine for psychotic symptoms, monitor for EPS and NMS *short dose for short period
  • levodopa-carbidopa for Parkinsonism
  • melatonin and clonazepam for REM sleep behavior disorder
54
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
6. Frontotemporal dementia
7. Normal pressure hydrocephalus

A
  1. Frontotemporal dementia
    A. Clinical - deficits in attention, abstraction, planning, problem solving; spares memory and motor function
    i. behavioral type - disinhibition, overeating, decline in executive abilities, perseveration, lack of sympathy, apathy
    ii. language variant - primary progressive aphasia
    *increased antipsychotic sensitivity (like with Lewy body)
    B. Diagnosis - definitively only postmortem –> atrophy of frontal and temporal lobes
    - presents bw 45 and 65
    C. Treatment - serotonergic (SSRIs, trazodone) to reduce disinhibition, anxiety, impulsivity, repetitive behaviors, eating disorders

*HIV infection can also affect executive functioning (CD4 <200)

  1. NPH
    A. Clinical - wet, wobbly, wacky
    B. Diagnosis - enlargement of ventricles out of proportion to cortical atrophy; clinical improvement with CSF removal via lumbar puncture
    C. Treatment - ventriculoperitoneal shunt
    - cognitive impairment least likely to improve
55
Q

[Neurocognitive Disorders]
Clinical presentation, diagnosis, and treatment of:
8. Huntington’s disease
9. Prion disease

A
  1. Huntington’s disease
    A. Clinical - motor (chorea, bradykinesia), cognitive (executive function), psychiatric sx (depression, impulsivity, irritability, obsessions)
    - increased rate of suicide
    B. Diagnosis - CAG repeats encoding Huntington protein, AD inheritance (Avg age of onset = 40)
    C. Treatment - symptom directed –> tetrabenazine or SGAs (atypicals)
  2. Prion disease
    A. Clinical - rapidly progressive cognitive decline; difficulties with concentration, memory, judgment
    - myoclonus (startle reflex), akinetic mutism
    - basal ganglia and cerebellum –> ataxia, nystagmus, hypokinesia
    B. Diagnosis - familial (AD) - CJD, or iatrogenic
    - lesions in putamen or caudate nucleus, sharp waves on EEG, or 14-3-3 proteins in CSF
    C. Treatment - none
56
Q

[Geriatric Psych]

  1. Compare pseudodementia to dementia
  2. Treatment of pseudodementia vs behavioral symptoms of dementia
A
  1. Pseudodementia - 2/2 to MDD, reversible
    - more acute onset
    - sundowning uncommon
    - often answers “idk”
    - patient aware of problems
    - cognitive deficits improve with antidepressants
  2. A. Pseudodementia Treatment
    - low dose SSRIs
    - avoid TCAs but if you do, use nortriptyline (Fewer ACh side effects
    - mirtazapine - to help with depression, sleep, appetite
    - methyphenidate - adjunct to antidepressants but causes insomnia, arrhythmia in cardiac patients

B. Behavioral symptoms treatment (seen in dementia)

  • nonpharma tx preferred (pet, art therapy, reduce stimuli, reorient patient)
  • pharma - avoid antipsychotics but can give olanzapine or quetiapine if symptoms severe, or short-term haloperidol or risperidone; avoid benzos and watch for paradoxical agitation
57
Q

[Geriatric Psych]

  1. Sleep changes in elderly
  2. Age-related effects of alcohol
A
  1. Sleep changes in elderly
    - decreased REM sleep latency (reach REM faster) –> decreased stages 3 and 4 non-REM deep sleep
    - decreased REM time overall
    - increased stages 1 and 2 non-REM sleep
    - frequent nocturnal awakenings
    - prolonged sleep latency (time to fall asleep)
    - earlier to bed, earlier to rise; decreased sleep overall
    * avoid sedative-hypnotics, if you must give trazodone
  2. Alcohol
    - decreased alcohol dehydrogenase, total body water –> higher BALs
    - increased CNS sensitivity
    - H2 blockers also lead to higher BALs
    - reserpine/nitro/hydralazine –> increased risk of hypotension
58
Q

[Child Psych]
Criteria, etiology, and treatment for:
1. Intellectual disability

A
  1. Intellectual disability

A. Criteria -

  • deficits in intellectual functioning e.g. learning, judgment, planning
  • deficits in adaptive functioning e.g. communication
  • at least 2 SDs below population mean

B. Causes

  • genetic - Down syndrome, Fragile X, PKU, Prader-Willi, Angelman, Williams, Rett, Cri-du-Chat
  • prenatal - TORCHes (TOxo, Rubella, Cmv, HIV, HErpes, Syphilis)
  • fetal alcohol syndrome (also growth retardation, smooth philtrum, thin lips)
  • perinatal - anoxia, prematurity, meningitis
  • postnatal - malnutrition, toxins, trauma, hypothyroid
59
Q

[Child Psych]
Criteria, etiology, and treatment for:
2. ADHD

A
  1. ADHD

A. Criteria - 6+ symptoms in either category:

i. inattention - easily distracted, loses things, struggles with instructions, unorganized, makes careless mistakes
ii. hyperactivity - fidgets, restless, acts as if driven by a motor, talks a lot, difficulty waiting, interrupts
- symptoms 6+ months and present in 2+ settings (home, school, work)
- onset prior to age 12, but can be dxed retrospectively in adulthood
- low self-esteem

B. Causes - multifactorial - genetics, low birth weight, smoking/ETOH during pregnancy

C. Treatment -

  • 1st line are stimulants –>methylphenidate (Ritalin), dextroamphetamine (Adderall) *do not give if there is co-occurring tic disorder
  • norepi reuptake inhibitor –> atomexitine
  • sympatholytic alpha2 agonists –> clonidine (sedation, bradycardia), guanfacine (lower risk orthostasis)
60
Q

[Child Psych]
Criteria, etiology, and treatment for:
3. Autism

A
  1. Autism - ASD

A. Criteria -

  • problems with social interaction and communication e.g. decreased eye contact, lack of interest in peer
  • restricted, repetitive patterns of behavior or interests e.g. rituals, hand flapping, hypersensitive to sounds
  • rapid deterioration of language / social skills during first 2 years of life

B. Causes - multifactorial - prenatal infections, low birth weight, genetics (Fragile X syndrome), associated with epilepsy
- increased total brain volume

C. Treatment - predictors of adult outcome are level of intellect and language impairment

  • early intervention, behavioral therapy
  • low dose antipsychotics (risperidone, aripiprazole) to reduce irritability, disruptive behavior
61
Q

[Child Psych]
Criteria, etiology, and treatment for:
3. Tic Disorders
4. Elimination Disorder

A
  1. Tic Disorders - Tourette’s, provisional tic (<1 year)
    tic - sudden, rapid, stereotyped movement or vocalization due to overactive D2R
    A. Criteria - multiple motor and at least one vocal tics
    - Tourette’s: >1 year, onset prior to age 18
    - provisional tic disorder - tics for <1 year
    - persistent motor OR vocal tic disorder
    *symptoms not required to cause significant distress to diagnose
    B. Causes - genetic, psychological
    - onset 4-6 yo, worst at 10-12 years old
    - Tourettes comorbid with OCD and ADHD
    - less white matter in prefrontal cortex
    C. Treatment - habit reversal therapy
    - sympatholytic alpha 2 agonists –> guanfacine, clonidine
    -both typical (pimozide) and atypical (haloperidol, risperidone) antipsychotics
  2. Elimination Disorder
    A. Criteria
    - enuresis (bed wetting) - urination 2x/week for >3 months when 5+ years old during sleep OR waking hours
    - encopresis - defecation >1x/month for >3 month when 4+ years old
    B. Etiology - psychosocial stressors –> 2/2 incontinence
    - encopresis often related to constipation with overflow
    C. Treatment - only treat if sx are distressing / impairing
    - psychoeducation first (limit fluid intake, behavioral program)
    - parent mgmt if child is doing it intentionally
    - pharma (esp for daytime enuresis) –> desmopressin, imipramine
62
Q

[Child Psych]
Criteria, etiology, and treatment for:
4. Oppositional Defiant Disorder
5. Conduct disorder

A
  1. Oppositional Defiant Disorder
    A. Criteria - 4+ symptoms for >6 months (with 1+ individual who is NOT a sibling)
    - anger/irritable mood - loses temper, resentful
    - argumentative / defiant behavior - breaks rules, argues with authority figures
    - vindictiveness - at least 2x in 6 months
    *does NOT involve physical aggression
    B. Etiology - more common if parents have mood d/o, ODD, CD, etc or mom has depression
    C. Treatment - behavior modification
  2. Conduct disorder
    A. Criteria - violating rights of others with >3 behaviors over last year, and >1 behavior w/in 6 mos, and no remorse or empathy:
    - aggression towards people and animals
    - destruction of property
    - deceitfulness or theft
    - serious violations - truancy, prostitution
    B. Etiology - comorbid with ADHD and ODD
    C. Treatment - behavior modification, parent mgmt training
63
Q

[Dissociative Disorders]
Criteria and treatment for:
1. Depersonalization/derealization disorder
2. Dissociative amnesia

A
  1. Depersonalization/derealization disorder
    A. Criteria -
    - derealization - detachment from surroundings (as if in dream or movie)
    - depersonalization - detachment from body, thoughts, actions (out-of-body experience)
    - reality testing remains intact and NO memory loss
    B. Treatment - psychotherapy, NO meds
  2. Dissociative amnesia
    A. Criteria - inability to recall important autobiographical information, usually involving traumatic event
    - procedural memory intact
    - can be w/ or w/out fugue state - unexpected travel away from home
    - can experience flashbacks, nightmares of trauma
    B. Treatment - psychotherapy, NO meds used
64
Q

[Dissociative Disorders]
Criteria and treatment for:
3. Dissociative Identity Disorder

*red flags for physical vs sexual child abuse

A
  1. Dissociative Identity Disorder i.e. DID

A. Criteria - 2 or more distinct personality states dominating at different times
- extensive memory lapses in autobiographical info
- seen in victims of severe and chronic/childhood trauma (abuse, neglect)
- symptoms similar to borderline e.g. frequent suicide attempts
B. Treatment - psychotherapy, prazosin for nightmares, naltrexone to reduce self-mutilation

  • Physical abuse - spiral bone fractures, head injuries, injuries in various stages of healing
  • sexual abuse - recurrent UTIs, prepubertal bleeding, inappropriate sexual knowledge
65
Q

[Somatic Disorders]
Criteria and treatment for:
1. Somatic Symptom Disorder
2. Conversion disorder

A
  1. Somatic Symptom Disorder
    A. Criteria - at least one somatic symptom (e.g. pain) for >6 months that causes distress
    - very concerned and anxious, sx worse when stressed (are substitute for repressed impulses)
    - do not intentionally produce or feign symptoms
    B. Treatment - regularly scheduled visits with one PCP, address psych issues slowly
  2. Conversion disorder
    A. Criteria - at least one neurological symptom (motor or sensory) e.g. blindness, paralysis, paresthesia, mutism, seizures, globus sensation - not explained by neuro condition
    - if affect is incongruent –> la belle indifference
    B. Treatment - education about illness, CBT, PT
66
Q
[Somatic Disorders]
Criteria and treatment for: 
3. Illness anxiety disorder
4. Factitious disorder
5. Malingering
A
  1. Illness anxiety disorder
    A. Criteria - preoccupation with and anxiety about having serious illness for >6 months
    - somatic symptoms not present
    - most have comorbid mental disorder
    B. Treatment - regularly scheduled visits with one PCP, CBT
  2. Factitious disorder
    A. Criteria - falsification of physical or psychological symptoms e.g. hallucinations, hypoglycemia, seizures, hematuria to assume role of sick patient
    - absence of external rewards (motivation is unconscious emotional gain)
    B. Treatment - collect collateral info, confront in nonthreatening manner
  3. Malingering
    A. Criteria - NOT considered to be mental illness; multiple vague complaints, uncooperative, symptoms improve after objective is obtained
    - conscious external motivation
67
Q
[Impulse Control Disorders]
Criteria and treatment for: 
1. Intermittent explosive disorder
2. Kleptomania
3. Pyromania
A
  1. Intermittent explosive disorder
    A. Criteria -
    - frequent verbal/physical outbursts that do NOT result in physical damage 2x / week for 3 months
    OR
    - rare outbursts resulting in physical damage >3x / year
    - outbursts out of proportion to trigger and not premeditated
    B. Treatment - SSRIs, mood stabilizers (lithium, anticonvulsants), CBT
  2. Kleptomania
    A. Criteria - failure to resist uncontrollable urges to steal objects not needed for personal use or monetary value
    - tension prior | pleasure/relief while stealing | guilt and depression afterwards
    B. Treatment - CBT, SSRIs
    *co-occurence with bulimia (decreased serotonin)
  3. Pyromania
    A. Criteria - impulse to start fires to relieve tension; at least 2 episodes of deliberate fire setting
    B. Treatment - none standard
68
Q

[Eating Disorders]
Criteria, clinical (physical / labs / imaging), and treatment for:
1. Anorexia nervosa

A
  1. Anorexia nervosa
    A. Criteria - restriction of energy intake leading to low body weight (BMI < 18.5); intense fear of gaining weight and disturbed body image
    i. restricting type
    ii. binge eating / purging type

B. Clinical - decreased resting energy expenditure –> hypotension, bradycardia, hypothermia

i. Physical - amenorrhea, parotid enlargement, lanugo, edema, alopecia, osteopenia
i. Labs
- hyponatremia, reduced LH/FSH/estrogen
- increased amylase, BUN, cholesterol, GH, cortisol
- anemia (normocytic normochromic) and leukopenia
iii. Imaging - enlarged ventricles, QTc prolongation
* not eating triggers dopamine surge –> becomes rewarding and addicting

C. Treatment - outpatient unless medically unstable or way below ideal body weight

  • CBT, family therapy
  • SSRIs for comorbid depression and anxiety
  • watch for refeeding syndrome (fluid retention, decreased Mg Ca Po4 –> arrhythmias, delirium, respiratory failure); slow feedings and replace electrolytes
69
Q

[Eating Disorders]
Criteria, clinical (physical / labs / imaging), and treatment for:
2. Bulimia nervosa

A
  1. Bulimia nervosa

A. Criteria - recurrent episodes of binge eating then compensation (vomiting, fasting, exercise) at least 1x / week for 3 months

  • maintain normal weight or overweight
  • usually ego-dystonic (distressing)

B. Clinical -

i. Physical - salivary gland elargement, callouses on hand, dental erosion, petechiae, peripheral edema
ii. Labs - hypochloremic hypokalemic metabolic alkalosis, metabolic acidosis (laxative abuse), elevated bicarb, hypernatremia
- increased amylase, BUN (as in anorexia)
- normal cortisol (increased in anorexia)

C. Treatment - SSRIs - fluoxetine
- therapy (CBT, group, family)

70
Q

[Eating Disorders]
Criteria, clinical (physical / labs / imaging), and treatment for:
3. Binge-eating disorder

A
  1. Binge-eating disorder
    A. Criteria - recurrent episodes of binge eating (2 hour period, lack of control) at least 1x / week for >3 months – no compensatory behaviors – and with 3+ of the following:
    - eating rapidly
    - eating until v full
    - eating when not hungry
    - eating alone due to embarrassment
    - feeling disgusted / depressed / guilty after eating

B. Clinical - obese patients

C. Treatment - CBT with strict diet and exercise program

  • stimulants (amphetamine) - suppress appetite
  • topiramate - antiepileptic associated with weight loss
  • orlistat - inhibits pancreatic lipase –> decreased fat absorption
71
Q

[Sleep-Wake Disorders]
normal sleep-wake cycle
Dyssomnias:
1. Insomnia disorder

A

Normal cycle -
REM sleep every 90 min, EEG as if awake, increased BP, RR< HR
non-REM is slower brain wave patterns and higher arousal thresholds

  1. Insomnia disorder
    A. Criteria - difficulty initiating or maintaining sleep, or awakening with inability to return to sleep
    i. acute insomnia - at least 3x / week for < 3 months, usually resolves spontaneously
    ii. chronic - 3 months to years
    B. Treatment - CBT is first line
    - benzos for short-term to reduce time to sleep and nocturnal awakening
    - zolpidem, eszopiclone, zaleplon for short-term treatment
    - trazodone, amitriptyline
72
Q

[Sleep-Wake Disorders]
Dyssomnias:
2. Hypersomnolence disorder
3. Obstructive sleep apnea hypopnea

A
  1. Hypersomnolence disorder
    A. Criteria - excessive sleepiness despite 7+ hours of sleep, at least 3 x / week for >3 months, with 1+ of the following:
    - recurrent sleeps in same day
    - nonrestorative sleep > 9 hours
    - sleep drunkenness (impaired performance after waking up)
    - can be due to viral infections (EBV, HIV, GBS) or head trauma or genetics
    B. Treatment - life-long therapy with modafinil or methylphenidate; atomexitine 2nd line
  2. Obstructive sleep apnea hypopnea
    A. Criteria - apneic episodes w cessation of breathing or reduced airflow due to upper airway collapse
    - frequent awakenings due to gasping, choking; snoring
    - POWERNAP: pulm HTN, other, wet sheets, erythropoiesis, reduced libido, nocturia, AM headaches, psych sx (eg depression)
    *can lead to cor pulmonale, respiratory failure
    B. Treatment - CPAP, BIPAP 2nd line
73
Q

[Sleep-Wake Disorders]
Dyssomnias:
4. Central sleep apnea
5. Narcolepsy

A
  1. Central sleep apnea
    A. Criteria - 5+ central apneas per hour of sleep
    - due to Cheyne-stokes breathing (crescendo-decrescendo variation in TV due to HF, stroke, renal failure)
    - OR due to opioid use
    B. Treatment - treat underling condition, CPAP/BIPAP, 02, acetazolamide, theophylline (promotes breathing)
  2. Narcolepsy
    A. Criteria - napping or lapsing into sleep at least 3x / week for >3 months associated with 1 of the following:
    - cataplexy - loss of muscle tone
    - ↓ hypocretin (orexin) in CSF
    - ↓ REM sleep latency (via polysomnogram or multiple sleep latency test); ↓ sleep latency, ↓ sleep efficiency, ↑REM density
    *hallucinations and/or sleep paralysis common
    B. Treatment - scheduled naps
    - daytime sleepiness –> amphetamines, methylphenidate, modafinil
    - cataplexy –> sodium oxybate is 1st line; TCAs, SSRI/SNRIs
74
Q
[Sleep-Wake Disorders]
Dyssomnias: 
6. Circadian rhythm sleep-wake disorders 
i. delayed sleep phase
ii. advanced sleep phase
iii. shift-work
iv. jet lag
A
  1. Circadian rhythm sleep-wake disorders
    * circadian rhythm controlled by suprachiasmatic nucleus in hypothalamus

i. delayed sleep phase - delay in sleep onset with preserved quality and duration of sleep; due to caffeine, puberty (changes in melatonin)
- treat with timed bright lights, melatonin

ii. advanced sleep phase - sleep onset and awakening earlier than desired with preserved quality and duration of sleep; due to old age
- treat with timed bright lights

iii. shift-work - 2/2 to rotating shifts
- treat with timed bright lights, modafanil

iv. jet lag - due to travel across time zones
- generally resolves on its own

75
Q
[Sleep-Wake Disorders]
Parasomnias
Non-REM sleep behavior disorders: 
1. Sleepwalking
2. Sleep terrors
3. Nightmare disorder
A
  1. Sleepwalking
    A. Criteria - occurs during non-REM slow wave sleep
    - difficulty arousing, eyes open with blank stare, and amnesia of episode
    B. Treatment - reassurance, condition is benign and self-limited to 1-2 years
    - if refractory, low-dose benzos (clonazepam Klonopin)
  2. Sleep terrors - peak at age 6
    A. Criteria - sudden terror arousals w screaming / crying, during non-REM slow-wave sleep with autonomic arousal (tachycardia, tachypnea, diaphoresis, mydriasis)
    - amnesia of episode and no recall of dreams
    B. Treatment - same as sleepwalking (Reassurance)
  3. Nightmare disorder
    A. Criteria - frightening dreams in second half of sleep, awakening with vivid recall but no confusion
    - occurs during REM sleep
    B. Treatment - reassurance, desensitization / imagery rehearsal therapy, prazosin (for PTSD)
76
Q

[Sleep-Wake Disorders]
Parasomnias
4. REM sleep behavior disorder
5. Restless legs syndrome

A
  1. REM sleep behavior disorder - in second half of sleep
    A. Criteria - repeated arousals during sleep with vocalization or dream-enacting behaviors e.g. talking, yelling, jerking, punching, running
    *usually muscle atonia during REM
    - seen with TCAs, SSRI/SNRIs, BBs; in elderly, narcolepsy; in neurodegenerative disorders (Lewy body, PD)
    B. Treatment - d/c meds, clonazepam, melatonin
  2. Restless legs syndrome
    A. Criteria - urge to move legs due to unpleasant sensation, occurs or worsens in evening
    - due to iron deficiency, genetics, drugs
    B. Treatment - d/c meds, iron replacement if low ferritin, dopamine agonists (ropinirole), benzos, opioids
77
Q

[Sexual Disorders]

  1. Sexual dysfunctions
  2. Gender dysphoria
  3. Paraphilias
A
  1. Sexual dysfunctions -
    A. Criteria - problems with any stage of sexual response cycle (desire, arousal, orgasm, resolution) causing significant distress
    - MC in males - erectile disorder, premature ejaculation
    - MC in females - sexual interest disorder, orgasmic disorder
    *dopamine increases libido, 5HT decreases it
    B. Treatment - sex therapy, CBT, hypnosis, meds (ED –> PDE5 inhibitors and alprostadil which automatically works w/in 3 min; SSRIs for premature ejaculation, hormone replacement)
  2. Gender dysphoria
    A. Criteria - marked incongruence bw experienced gender and sex characteristics with desire to be of or be treated as other gender
    B. Treatment - therapy, sex reassignment after 1 year of living as other gender and 1 year of hormone therapy
  3. Paraphilias -
    A. Criteria - unusual sexual activities > 6 months that are intense, recurrent, and interfere with daily life e.g. pedophilia, voyeurism, exhibitionism, BDSM, transvestitism
    B. Treatment - CBT, social skills training, meds to decrease sex drive (SSRI, naltrexone, antiandrogens)
78
Q

[Psychotherapies]

  1. Freud’s theory of the mind
  2. Mature defenses
  3. Neurotic defenses
  4. Immature defenses
A
  1. Freud
    i. id - present at birth; unconscious, instinctual sexual/aggressive urges
    ii. supergo - present by age 6; moral conscience, internalized cultural rules, ego ideal
    iii. ego - present after birth; mediator bw id, supego, and environment using defense mechanisms and reality testing
  2. Mature defenses - altruism, sublimation, suppression, humor
  3. Neurotic defenses - controlling, displacement, intellectualization, isolation of affect, rationalization, reaction formation (doing opposite of unacceptable impulse), repression
  4. Immature defenses - acting out, denial, regression, projection, splitting
79
Q
[Psychopharm]
Side effects: 
1. anticholinergic 
2. antihistamine
3. antiadrenergic
4. serotonin syndrome
5. NMS 
6. CYP450 inducers vs inhibitors
A
  1. anticholinergic - hot as a hare, blind as a bat, dry as a bone, mad as a hatter (exacerbate dementia) + constipation
  2. antihistamine - sedation, weight gain
  3. antiadrenergic - peripheral vasodilation, orthostatic hypotension
  4. serotonin syndrome - when SSRIs are combined with MAOIs, triptans, dextromethorphan (cough syrup) - overactivation of 5HT1AR –> myoclonus, flushing / diaphoresis / tremor, hyperthermia, rhabdo, renal failure, death
    - need 2 week break, with fluoxetine need 5 weeks bc of long t1/2
    - d/c meds and give benzos, cyproheptadine (5HT antagonist)
  5. neuroleptic malignant syndrome - due to inhibition of D2R –> fever (MC sx), AMS, HTN, tremor, lead pipe rigidity (“unable to move spontaneously”), elevated WBC and CPK –> rhabdo –> AKI and hyperkalemia –> arrhythmia and death
    - treat with supportive measures, bromocriptine and amantadine, lorazepam; for severe cases –> dantrolene, ECT
  6. CYP450 inducers - st johns wort, carbamazepine, phenytoin, tobacco, barbs, rifampin
    Inhibitors - SSRI/SNRIs
80
Q
[Psychopharm]
Antidepressants
MOA, examples of / indications, and side effects of: 
1. SSRIs
- fluoxetine
- sertraline
- paroxetine
- fluvoxamine
- citalopram
- escitalopram
A
  1. SSRIs - for MDD, OCD, panic disorder, eating disorders, social phobia, GAD, PTSD, IBS, PMS

A. MOA - inhibit presynaptic serotonin reuptake –> increased 5HT in synaptic clefts

  • increase brain plasticity –> delay to onset of effect
  • NO correlation bw plasma levels and efficacy or side effects

B. Examples:

  • fluoxetine - longest t1/2, 1st line for pediatric depression; can increase levels of antipsychotics and carbemazepine
  • sertraline - more GI probs; preferred for breastfeeding
  • paroxetine - short t/12 –> increased risk of discontinuation syndrome; teratogen - can cause atrial septal defect
  • fluvoxamine - only for OCD
  • citalopram - fewest drug interactions, dose- dependent QTc prolongation
  • escitalopram - also QTc prolongation

C. Side effects

  • GI (nausea/vomiting), insomnia, headache, anorexia / weight loss, sexual dysfunction, SIADH (rare)
  • GI bleed due to platelet dysfunction (increased bleeding time) *prescribe PPI to offset
  • bruxism
  • black box warning for increased suicidal ideation in <25 years old
  • serotonin syndrome - triptans, MDMA, MAOIs, tramadol
  • can increase levels of warfarin
  • discontinuation syndrome - flu-like sx; restart same drug and then taper over several weeks or fluoxetine (don’t need taper bc of active metabolites)
81
Q
[Psychopharm]
Antidepressants
MOA, examples of / indications, and side effects of: 
2. SNRIs
3. Bupropion
4. Mirtazapine
A
  1. SNRIs
    A. MOA - inhibit serotonin and norepi reputake
    B. Examples
    - venlafaxine - for GAD + depression, and neuropathic and chronic pain; increased BP w higher doses; abrupt d/c can lead to d/c syndrome (flu-like sx, depression)
    - duloxetine - for fibromyalgia + depression, neuropathic pain; can be hepatotoxic in pts with ETOH, liver dx
    - dry mouth, constipation, urinary retention
  2. Bupropion
    A. MOA - norepi and dopamine reuptake inhibitor
    B. Indications - depression, smoking cessation
    C. Side effects - activating and lack of sexual side effects, but can lower seizure threshold in pts with epilepsy, eating disorders, or those taking MAOIs
  3. Mirtazapine
    A. MOA - alpha2 adrenergic receptor antagonist
    B. Indications - major depression in pts with weight loss and insomnia
    C. Side effects - sedation, weight gain, agranulocytosis (neutropenia - rare), lack of sexual side effects
82
Q

[Psychopharm]
Antidepressants
MOA, examples of / indications, and side effects of:

  1. Trazodone
  2. TCAs
A
  1. Trazodone
    A. MOA - antagonist of 5HT2 receptors and inhibits reuptake
    B. Indications - MDD, insomnia
    C. Side effects - priapism, sedation, hypotension with higher doses
  2. TCAs
    A. MOA - inhibit reuptake norepi and serotonin
    B. Examples / indications
    - amitriptyline - migraines, neuropathic chronic pain
    - imipramine - enuresis
    - clomipramine - 2nd line in OCD
    - doxepin - sleep aid
    - notriptyline and desipramine - secondary amine, less side effects (better in elderly)
    C. Side effects - coma, convulsions, cardiotoxicity (QTc prolongation, arrhythmias); can cause delirium
    - lethal in OD (give sodium bicarb)
    - anticholinergic, antihistaminic, antiadrenergic
83
Q

[Psychopharm]
Antidepressants
MOA, examples of / indications, and side effects of:

  1. MAOIs
A
  1. MAOIs

A. MOA - irreversibly inhibit MAO-A and MAO-B which break down neurotransmitters

  • MAO -A –> 5HT, norepi, dopa, tyramine
  • MAO - B –> dopa, phenethlyamine, tyramine

B. Examples - for refractory depression, atypical subtype

  • selegiline
  • phenelzine
  • tranylcypromine
  • isocarboxazid

C. Side effects - most common is orthostasis

  • hypertensive crisis with tyramine - rich foods (red wine, cheese, cured meats, fava beans) bc MAOs not able to break down norepi displaced from storage vesicles by tyramine –> HTN, photophobia, chest pain, n/v, sweating, arrhythmias, death; treat with phentolamine, nitroprusside
  • serotonin syndrome
  • weight gain, sexual dysfunction, sleep problems, dry mouth
  • pyrodixine deficiency –> numbness, paresthesias
84
Q
[Psychopharm]
Antipsychotics 
MOA, examples of / indications, and side effects of: 
1. Typical antipsychotics 
incl low medium, and high potency
A
  1. Typical, first generation antipsychotics

A. MOA - block dopamine (D2) receptors –> decreased binding of dopamine at the postsynaptic receptor

B. Examples / indications and side effects

i. Low-potency - increased antiH1, alpha1, muscarinic, highest seizure risk
- chlorpromazine - treat hiccups, cause blue-gray skin discoloration and photosensitivity, deposits in cornea
- thioridazine - irreversible retinal pigmentation
ii. midpotency - perphenazine
iii. high potency - greater EPS side effects, decreased alpha1, H1, anticholinergic side effects
- haloperidol *long acting IM form is decanoate; decreased risk anticholinergic side effects
- fluphenazine - also has decanoate form
- trifluoperazine
- pimozide - interacts with citalopram –> QTc prolongation, vtach

C. General Side effects

  • antidopa (EPS, hyperPRL) –> give benztropine, diphenhydramine
  • antiH1, antialpha1, antimuscarinic
  • tardive dyskinesia
  • NMS - more common in young males early in treatment on high potency
85
Q
[Psychopharm]
Antipsychotics 
MOA, examples of / indications, and side effects of: 
2. Atypical antipsychotics 
- clozapine
- risperidone
- quetiapine
- olanzapine
- ziprasidone
- aripiprazole
- lurasidone
A
  1. Atypical antipsychotics
    A. MOA - block both dopamine (D4>D2) and serotonin (5HT2) receptors
    - for acute mania (bipolar), schizophrenia (+ and - sx), and also for treatment resistant depression and tic disorders
    *serotonin inhibits dopamine in nigrostriatal tract –> 5HT inhibition increases dopa –> fewer EPS

B. Examples and side effects

  • clozapine - treatment-refractory schizo because associated with neutropenia (weekly blood draws for first 6 mos, stop if neutrophils <1500/microliter or fever), myocarditis, seizures; lowest risk EPS but highest anticholinergic (e.g. drooling - give PTU) *only antipsychotic that decreases suicidality
  • risperidone - increased risk of high prolactin
  • quetiapine - sedation, hypotension; lowest risk EPS
  • olanzapine - worst for weight gain, metabolic syndrome
  • ziprasidone - QTc prolong, weight neutral, take w food
  • aripiprazole - partial D2 agonist –> more activating (akathisia); least likely to cause QTc prolongation; weight-neutral
  • lurasidone - bipolar depression, take w food

C. General side effects - less likely to cause EPS, TD, NMS

  • cause anticholinergic, anthistaminic, antialpha1 side effects
  • metabolic syndrome - HLD, DKA, weight gain –> measure waist circumference, BP, glucose, lipids
  • elevated LFTs and ammonia - measure yearly

atypicals used to treat behavioral sx of dementia and delirium but associated with increased risk of stroke and mortality in elderly

86
Q

[Psychopharm]
Mood stabilizers
MOA, examples of / indications, and side effects of:
Lithium

A

Lithium

A. MOA - unknown

B. Indications - 1st line in acute mania, prophylaxis for bipolar and schizoaffective disorders
- also cyclothymic, unipolar depression

C. Side effects - therapeutic dose can cause benign fine tremor (give propranolol)

  • narrow TI –> check blood levels of lithium also get BMP, TFTs, UA, Ca + pregnancy test
    i. acute - coarse tremor/seizures, ataxia/nystagmus, polyuria/polydipsia, n/v, diarrhea, AMS, cardiac arrhythmias (AV block, T wave flattening)
    ii. chronic - nephrogenic DI, CKD, hypothyroidism, hyperparathyroidism
    iii. teratogenic - Ebstein’s anomaly
  • metabolized by kidney – be careful in pts with CKD
  • Lithium levels increased with thiazides, NSAIDs, ACEIs, tetracyclines, metronidazole, dehydration, salt deprivation / sweating, and CKD
  • Li is only mood stabilizer shown to decrease suicidality
87
Q

[Psychopharm]
Anticonvulsants
MOA, examples of / indications, and side effects of:

  1. Carbamazepine
  2. Lamotrogine
A
  1. Carbamazepine
    A. MOA - blocks sodium channels and inhibits action potentials
    B. Indications - mania with mixed features, rapid cycling bipolar
    C. Side effects - GI, ataxia, confusion, aplastic anemia, SIADH, alopecia / acne, hepatotoxicity, SJS, teratogenic (neural tube defects)
    - induces CYP450 pathway
    - toxicity –> ataxia, tremor, nystagmus / diplopia, twitching, vomiting, stupor
  2. Lamotrogine
    A. MOA - sodium channels that modulate glutamate, aspartate
    B. Indications - bipolar depression (NOT for acute mania)
    C. Side effects - rash, decreases valproate levels
    - SJS - widespread confluent rash with fever, WBC, affects mucosal membranes
88
Q

[Psychopharm]
Anticonvulsants
MOA, examples of / indications, and side effects of:

  1. Valproic acid
  2. Topiramate
A
  1. Valproic acid (Valproate)
    A. MOA - blocks sodium channels, increases GABA
    B. Indications - acute mania, mania with mixed features, rapid cycling
    C. Side effects - GI distress, weight gain, PCOS, tremor, sedation, hyperammonemia
    - pancreatitis - at any point
    - hepatotoxicity - dose-dependent
    - teratogen (neural tube defects), causes PCOS
    - increases lamotrigine levels
  2. Topiramate
    A. MOA - also blocks sodium channels
    B. Indications- used for migraine prophylaxis, pseudotumor cerebri
    C. Side effects - causes weight loss, cognitive slowing (Reversible decrease in IQ), kidney stones, metabolic acidosis
89
Q

[Psychopharm]
Anxiolytics/hypnotics
MOA, examples of / indications, and side effects of:
1. Benzodiazepines

A
  1. Benzodiazepines - GAD, alcohol w/d, muscle spasms, seizures / status epilepticus, anesthesia e.g. conscious sedation, sleep problems e.g. insomnia and parasomnias, panic disorder

A. MOA - increase frequency of GABA opening

B. Examples

i. long-acting (t1/2 >20 hrs)
- chlordiazepoxide (Librium) - for alcohol w/d, avoid in liver disease
- diazepam (Valium) - for muscle spasms, causes euphoria
- clonazepam (Klonopin) - for anxiety, panic attacks; avoid with CKD; most potent benzo

ii. intermediate (t1/2 6-20 hrs)
- alprazolam (Xanax) - for anxiety, causes euphoria; 2nd most potent benzo
- lorazepam (Ativan) - for alcohol detox, agitation, panic attacks, and catatonia
- oxazepam - for alcohol detox
- temazepam

iii. short-acting (t1/2 <6 hours)
- triazolam - for insomnia, risk of anterograde amnesia
- midazolam (Versed) - for conscious sedation

C. Side effects - drowsiness, life-threatening w/d

  • be careful - elderly – sensitive to side effects –> confusion, ataxia, falls
  • can die from respiratory depression if combined with ETHOD

*for alcoholics, give benzos NOT metabolized by liver –> lorazepam, oxazepam, temazepam

90
Q
[Psychopharm]
Anxiolytics/hypnotics
MOA, examples of / indications, and side effects of: 
2. Non-benzo hypnotics
3. Buspirone
4. Hydroxyzine
A
  1. Non-benzo hypnotics
    A. MOA - selective receptor binding to GABA-A receptor
    - for short-term tx of insomnia
    B. Examples - zolpidem, eszopiclone, zaleplon
    - also diphenhydramine, ramelteon (MT1 and 2 agonist)
    C. Side effects - anterograde amnesia, parasomnias, hallucinations
  2. Buspirone
    A. MOA - partial 5HT-1a agonist
    B. Indications - used in combo with SSRI for GAD
    C. Side effects - slow onset of action (1-2 weeks), low potential for abuse
  3. Hydroxyzine
    A. MOA - antihistamine
    B. Indications - quick-acting, short-term anxiolytic
91
Q
[Psychopharm]
Psychostimulants 
MOA, examples of / indications, and side effects of: 
1. Amphetamines
2. Atomexitine 
3. Modafinil
A
  1. Amphetamines e.g. dextroamphetamine, methylphenidate
    A. MOA - CNS stimulant that induces biogenic amine
    (dopa, 5HT) release from storage sites in synaptic terminals
    B. Indications - ADHD, tx refractory depression
    C. Side effects - weight loss, insomnia, seizures, abuse
    - leukopenia, anemia with methylphenidate
  2. Atomexitine
    A. MOA - inhibits presynaptic norepi reuptake –> increased norepi and dopa
    B. Indications - 2nd line for ADHD, hypersomnolence
    C. Side effects - less abuse potential, less effective, possible increase in SI
  3. Modafinil - CNS stimulant
    A. MOA - dopa reuptake inhibitor, activates release of orexins and histamine
    B. Indications - narcolepsy, OSA, shift work disorder
    C. Side effects - abuse potential
92
Q
[Psychopharm]
Psych side effects of the following: 
1. Procainamide, quinidine
2. Albuterol
3. INH
4. Tetracyclines
5. Nifedipine, verapamil
6. Cimetidine
7. Steroids
A
  1. Procainamide, quinidine - confusion, delirium
  2. Albuterol - anxiety, confusion
  3. INH - psychosis
  4. Tetracyclines - depression
  5. Nifedipine, verapamil (Ca2+ blockers as well as beta blockers) - depression
  6. Cimetidine - depression, confusion, psychosis
  7. Steroids - aggressiveness, mania, depression, anxiety, psychosis
93
Q

[Forensic path]

  1. Proving malpractice
  2. Informed consent & when its not required
  3. Emancipated minors
A
  1. Malpractice - physician had duty of care –> breached it via negligence (practicing below standard of care) –> patient was harmed, directly due to this negligence
  2. Informed consent - Reason for treatment, Risks/benefits, Reasonable alternatives, Refused treatment consequences
    - do not need informed consent in lifesaving emergency, emancipated minors, and prevention of suicidal or homicidal behavior
  3. Emancipated minors - self-supporting, in military, married, have children / pregnant –> do not need parental consent for medical decisions
94
Q

[Forensic path]

  1. What determines decisional capacity
  2. Determining competence
A
  1. Decisional capacity - communicates choice, understands condition/treatment options, acknowledges consequences of treatment options, and can weigh risks/benefits and offer reasons for decisions
  2. Competence - legally determined by judge
    - cannot be tried in court if not mentally competent (legally insane)
    - need evil deed and evil intent to be convicted - can be not guilty by reason of insanity (NGRI)
    * most important hactor in assessing risk of violence is patient’s previous history of violence (also young, male, lower SES)
95
Q
Description of sleep stages and EEG waveforms: 
1. Awake (Eyes open)
2. Awake (eyes closed) 
3. Non-REM sleep 
N1
N2
N3
4. REM sleep
A
  1. Awake (Eyes open) - beta (highest frequency, lowest amplitude)
  2. Awake (eyes closed) - alpha
  3. Non-REM sleep
    N1 - light sleep, theta waves
    N2 - deeper sleep, sleep spindles and K complexes; bruxism
    N3 - deepest sleep, where sleepwalking, bed wetting, and night terrors occur; delta waves
  4. REM sleep - muscle atonia, increased brain 02 use, where dreaming/nightmares/tumescence occur; beta waves
96
Q

Differentiate between IED, ODD, and DMDD

A

These disorders cannot coexist, must pick one

IED - 3 mos *impulse control disorder

  • outbursts of anger and aggression >2x/week or >3x / year (physical damage against people or property)
  • don’t need irritable mood bw outbursts
  • grossly out of proportion to trigger

ODD - 6 mos *disruptive disorder

  • anger/irritable mood
  • argumentative/defiance towards authorities
  • vindictiveness but no physical aggression
  • associated with conduct disorder

DMDD - 12 mos *mood disorder

  • verbal and/or physical temper outbursts >3x/week in 2+ settings
  • irritable bw outbursts
97
Q

Location of neurotransmitter synthesis: Ach, Dopa, GABA
norepi, 5HT

Levels during: 
anxiety
depression
schizo
alzheimer
huntington
parkinson
A

Location of neurotransmitter synthesis:

  • Ach - nucleus basalis of meynert (attention, memory, executive functions)
  • dopamine - ventral tegmentum, substantia nigra (movement, rewards)
  • GABA - nucleus accumbens (main inhibitor)
  • norepi - locus ceruleus (stress hormone, bv, attentiveness, learning)
  • serotonin - raphe nucleus (memory, emotions/moods, appetite, thermoregulation)
anxiety - 􏰀↓ GABA and 5HT, ↑ norepi
depression - ↓ dopa, 5HT, norepi 
schizo - ↑ dopa
alzheimer - ↓ ACh 
huntington - ↓ ACh and GABA, ↑ dopa 
parkinson - ↓ dopa, ↑ ACh, 5HT