Psych 3a Flashcards
Treating Depression
Medical
Adults: SSRI (Sertraline) SNRI (Venlafaxine)
Children: SSRI (Fluoxetine)
Elderly: Mirtazapine - also given to Warfarin Pts
SSRIS: citalopram, paroxetine SNRIS: duloxetine. Careful with Fluoxetin
When starting SSRI, prescribe for 6mths at least, avoid triptans
Medical treatments
Non Medical Treatments for Depression
Non medical 1st line: CBT, IAPT Fam therapy in CAMHS
Encourage resuming old activities
Side FX SSRIs
Sertraline, Citalopram, Fluoxetine
SSRI can increase risk of suicide so double check
GI symptoms (most common)
Sexual Impotence
Hyponatremia
Agitation, Weight gain
Upon Discontinuation: Restless, Sweating, Parasthesia, GI symptoms
Interactions: NSAID (Give PPI), Sumatriptan, Warfarin/Heparin
Fluoxetine and Paroxetine risks of interactions
Medical treatments
Other Treatments for Depression
other than SSRi and SNRI
Generally avoided
MAOI - Tranylcypromine, phenelzine Side FX: HTN crisis when taken with cheese, pickles etc.
TCAs - Amitriptyline Side Fx: Urinary retention, dry mouth, lethargy, blurry QT interval increased
These both are avoided due to side fx profile
MAOI treate atypical depression TCA commonly used for neuropathic pain and chronic TTH
Assesment and management Frontal Lobe Syndrome
Hx
- Developmental, Trauma & Social Hx
- Check B12. TFT, Syphilis screen
Management - General Supportive Care
- Speech therapy
Treatment Acute Mania
- Stop Anti-Depressants
- 1st line antipsychotics
Haloperidol, Olanzapine, Queitapine, Risperidone
Li can be used short term & Benzodiazepnes
Chronic Management of Bipolar Disorder
- CBT
- Mood stabilisers: Lithium
- 2nd Line: Na Valporate, Carbamezipine Olanzipine
Pregnancy use antipsychotic: Haloperidol
Lithium is teratogenic causing Ebsteins Foetal Anomaly
Treating Depression in Bipolar
- Avoid antidepressant (Can cause Mania)
- 1st line Antipsychotic: Quietapine
If you are to prescribe SSRI such as Fluoxetine then prescribe Mood stabiliser alongside it
Olanzapine can be used as Mood Stabiliser although it is a antipsychotic
Side FX Lithium
Due to narrow Therapeutic Index you must check LI bloods evry wk for 3w
Then check every 3m
Leukoytosis (Excess WBC)
Insipidus Diabetes
Tremors
Hydration (Dehydrates)
Increased GI motility
Underactive thyroid
Metallic Taste
Long-term lithium use can result in hyperparathyroidism and resultant hypercalcaemia (stones,bones, abdominal moans & psychic groans)
Wt gain, hypoparathyroidism
Think of a drunk man
Lithium Toxicity
Conc of LI in blood above 1.5mM
NEPHROTOXICITY
Reduced renal function due to Li accumulation leading to
- Dehydration
- D&V
- Sleepy
- Motor signs: Coarse Tremor + Hyperflexia
- Neuro: Confusion, seizures
Mild Toxicity: Stop Li & Rehydrate
Avoid with Li: NSAIDS, THiazide diuretics, ACEi, ARBs, metronidazole
Severe: Haemodialysis, Gastric Lavage, Diuretics
What is Dysthymia?
Not severe enough to be classed as something (Hint)
Treated with SSRI (Sertraline) + CBT
Chronic, midly depressed mood and diminished enjoyment
Presence of low grade symptoms for around 2y
Not severe enough to be classified as severe illness
What is Alogia
poverty of speech.
Refers to difficulty with speaking or the tendency to speak little due to brain impairment.
Treatment Schizophrenia
Antipsychotics
Extrapyramidal Side Fx caued by Typical Antipsychotics
1st line: Atypical (Quietapine, Olanzapine, Risperidone)
2nd Line: Typical (Haloperidol, Chlopromazine)
3rd Line: Clozapine
Treatment steps: 6mths -> 5Y -> Lifelong
Regular monitoring of: Wt, Lipids, Glucose, & ECG
Psycho: CBT Social: Housing, Financial Advice
4 Extra Pyramidal side Fx of Typical antipsychotics
Haloperidol Chlorpromazine
Increased risk of stroke and VTE
- Acute Dystonic Rxn (Hours)
Muscle spasms, acute torticolis, Eyes rolling back - Parkinsonism (Days)
Tremor, bradykinesia - Akathisia (Days to weeks)
Inner restlessness, agitation, suicide risk in young - Tardive Dyskinesia (Months to Years)
Grimacing, tongue protrusion, lip smacking
Difficult to treat Tardive Dyskinesia as Dr Receptors upregulated
Torticolis: Neck spasms Bradykinesia: slow movement
Side Fx Profile Antipsychotics
Apart from Extrapyramidal
Atypical (Clozapine, Queitapine, Olanzapine, Aripiprazole, Risperidone)
Typical (Haloperidol, Chlorpromazine)
Typical : Dry mouth, Galactorrhoea, Urinary retention, blurred vision, constipation, QT interval increase
Clozapine: Agranulocytosis
Olanzapine: Dyslipidaemia, Hyperlipidaemia
Agranulocytosis: Severe reduction in the number of white blood cells
Monitor clozapine evry week for 18wks
Treatment for Extrapyramidal Symptoms
Caused by Typical Antipsychotics like Haloperidol and Chlorpromazine
Procyclidine for Acute Dystonic Rxn
Tetrabenazine may be used to treat moderate/severe tardive dyskinesia
Young Age Dementia
Define Frontal Lobe Syndrome & Causes
fronto-temporal dementia
- Damage to prefrontal regions of frontal lobe
important in Motivation, planning, social behaviours, speech production - Damage leads to speech problems, reduced attention and abstract thoughts
Ubiquitin Deposits
Causes: Head Injury, CVA, Infection, Picks Disease (neurosyphillis)
Endocrine disorders causing Psych symptoms
DM, Thyroid, Parathyroid, Adrenal
- T1DM: Anorexia, Bulimia
- T2DM Bipolar, Schizo
- HyperThy: GAD, Depression, Thyroid storm -> Mania
- HypoThy: Depression, Myoxydema -> Psychosis
- HyperCalc: Depression, apathy, irritation
- HypoCalc: Anxiety, mania
- Cushings: Depression, anxiety, mania
- Addisons: Fatigue
Cushings: hyperaldosteronism: More cortisol
Addisons is opposite
Panic Disorder Vs GAD
generalised anxiety disorder
GAD: Constant worry with external stimulus of particular thing
Panic: Discreet episodes of anxiety w/out stimulus (spontaneous
RF for OCD
- FH
- Parental Overprotection
- PANDAS (Paediatric neuropsychiatric disorders associated with strep infection)
Dopamine
Pathophysiology of Schizophrenia
4 main dopaminergic pathways in the brain
- Mesolimbic Reward, excess dopamine here leads to +ve symptoms (Delusions, Hallucinations etc)
- Mesocortical Pre Frontal: low dopamine here -> -ve symptoms (anhedonia, blunted effect, alogia)
- Nigostriatal Basal Ganglia: excess dopamine -> motor movements
- Tuberoinfundibular: Excess dopamine -> rise in PRL (nipple leaks)
3 & 4 refer to Sid Fx of Antipsychotics
Dopamine in mesocortical needed for executive functioning such as emotion, speech
ALCOHOLISM
Investigation & Treatment for Drinking problem
Questionaiire
CAGE questionaire
- Have you ever tried to CUT down
- Have you been ANNOYED at the fact that you may have alcoholism
- Have you ever felt GUILTY
- Have you ever had an EYE OPENER first thing in morning
Alcohol dependence treatment
- Acute detox
- Psycho therapies
- Meds
Stepwise Detoxification from Alcohol
Alcohol dependence 4 drugs
- Benzos (Diazepam, Lorezepam, Chlordiazepoxide)
- Rehydration with correct electrolytes
- Thiamine
Disulfram - Prevents alcohol metabolism - causes nausea if you drink
Acamprostate - Reduce cravings
Naltrexone - Opiod antagonist
Treatment for Delirium Tremens
Acute withdrawal from alcohol
First line: Lorezepam or chlordiazepoxide
Treat with Thiamine
or Antipsychotics (Haloperidol)
Treatment for Delirium Tremens
Acute withdrawal from alcohol
Treat with Thiamine
Lorezepam or Antipsychotics (Haloperidol)
What is Korkasoff
Think Thiamine
Due to Alcohol misuse
- Short term memory loss + Cofabulation
Thiamine deficiency due to alcohol misuse
Damage to hypothalamus mamiliary bodies
Other Cause: Head Injury, Post anasthesia, Encephalitis CO poisoning
Treatment for Korkasoff Psychosis
- Oral Thiamine replacement therapy for up to 2Y
- Treat psychiatric co morbidities
- Cognitive Rehab
Caused by Thiamine B1 deficiency
Triad of Wernickes Encephalopathy
& Treatment
Develops further on from Korkasoff
- Opthalmoplegia (eye muscle paralysis)
- Ataxia
- Confusion
High risk Pts: prophylactic vit(s)
Treat with IV Pabrinex (vit)
Can also present alongside Korkasoff: Wernicke’s Korkasoff
Delirium Screening & Symptoms
- 4 AT assesment
Symptoms - Confusion
- Disorientation
- Hallucinations
- Agrresion
- Labile mood (yoyo)
ICD 10: cognitive, attention disturbance over short period of time
Delirium: evidence of physical cause
4A’s of Alzheimers
- Amnesia; Poor recent memory
- Apraxia: unable to button up
- Agnosia: unable to recognise body parts
- Aphasia: Struggle with language
Diagnosing Alzheimer’s
CT
- Brain atrophy, sulcul widening, large ventricles
- Amyloid Plaques
- Neurofibilary tangles
- Shrinkage of cortex
- Alzheimer’s disease causes widespread cerebral atrophy mainly involving the cortex and hippocampus
Use ACE III for diagnosis
Medical Management Alzheimer’s
Non Pharm:
Acitivities promoting wellbeing & group cognitive simulation therapy
1st: Ach inhibs: Donepezil, Rivastigmine, Galantamine
2nd NMDA antagonist: **Memantine ** (when 1st line contraindicated)
Mild-Moderate AD: 1st
Severe AD: 1st + 2nd line
Donepezil: insomnia, contraindicated bradycardia
Related to Parkinsonism
Lewy Body Dementia Features
Common in 50-80y
Same Treatment as AD
- Caused by Lewy bodies (alpha-synuclein cytoplasmic inclusions) in the substantia nigra
- Early impairments in attention and executive function rather than memory
- Parkinsonism
- Visual Hallucinations
- Fluctuating cognition (Confused for delirium)
Baby Blues
1st
- 60-70% women
- 3-7 days post birth
- Anxiety & Fearful
Treatment: Reassurance from Health Visitor
Post Natal Depression
2nd
- 10% Women
- Start at 1m peak at 3m
- Symptoms of Depression
- Reassurance + CBT
- SSRI (Sertraline)
SSRI can come in breast milk so be mindful
Puerperal Psychosis
3rd (most critical of the lot)
- 0.2% of Women
- 2wk Post Partum
- Bipolar 1 - Mania
- Disordered Perceptions
- Psych emergency
What is ECT?
What treatment is it used in?
Catatonia: a disorder that disrupts a person’s awareness of the world around them
- Treatment in Depression with catatonia
- +/- Psychotic Symptoms
- contraindicated in Raised ICP
Side Fx: Headache, nausea, arrythmias. Long term: Impaired memory
Schizoid Personality
Cluster A
- Indifferent to praise and criticism
- Prefers solitary activities
- No interest in sex
- cold
- few friends
What are the four Ps
- Predisposing
- Precipitating
- Perceptuating
- Protective
e.g. 1. Genetics 2.Particular event 3. Drinking 4. Support network
Depression and its Core 3 symptoms
Other symptoms: Sleep deprived, apetitie change, agitation, labile mood
- Pervasive Lowering of mood
1. Anhedonia
2. Low of mood
3. Loss of energy
ICD classification for Depression
Time frame + mild/moderate/severe
- At least 2/3 core symptoms
- over 2wks
Mild: Core + 2/3 symptoms
Moderate: Core +4 symptoms
Severe: Several symptoms +/- Suicide risk
also marked loss of functioning