Psych Flashcards
SSRIs
Fluoxetine, citalopram, sertraline, fluvoxamine, escitalopram
Use of SSRIs
Depression, panic disorder, ocd
SSRIs with fewer drug interactions
Citalopram & escitalopram
SSRI contraindications
MAO inhibitors (hyperthermia & CV collapse)
Caution in epilepsy & peptic ulcer disease
PPI if with aspirin or nsaids
SSRI adverse effects
8S
Size, Sick, Serotonin syndrome, Sexual dysfunction, Stomach upset, Stress, Suicide, Sleep difficulty, Sodium (low)
Serotonin syndrome
Triad of autonomic hyperactivity, altered mental state and neuromuscular excitation
What is a SNRI & example
Serotonin & Noradrenaline Reuptake Inhibitors
Venlafaxine, Duloxetine
Use of SNRI
When SSRI ineffective for depression
Generalised anxiety disorder (venlafaxine)
Noradrenergic & Specific Serotonin Antidepressant example
Mirtazapine
(Alpha 2 adrenoreceptor antagonists)
MAO - I
Monoamine oxidase inhibitors
Ipronoazid, Selegiline
Tricyclic antidepressants examples
Amitriptyline, imipramine, lofepramine
Tricyclic contraindications
Recent MI or Arrhythmia
Manic phase
Severe liver disease
Epilepsy
other anticholineric drugs, alcohol & adrenaline
Lidocaine
Adverse effects of tricyclics
Muscarinic blocking (dry mouth, blurred vision, constipation)
A-adrenergic blocking (postural hypotension)
Noradrenaline uptake block in heart (arrhythmias)
Histamine blocking - sedation
Weight gain
Categories of antidepressant
SSRI
SNRI
NaSSA
MAO-I
Tricyclics
Mood Stabilisers
Lithium
Carbamazepine
Sodium valproate
Lamotrigine