Psych

Question 1

SSRIs

Answer 1

Fluoxetine, citalopram, sertraline, fluvoxamine, escitalopram

Question 2

Use of SSRIs

Answer 2

Depression, panic disorder, ocd

Question 3

SSRIs with fewer drug interactions

Answer 3

Citalopram & escitalopram

Question 4

SSRI contraindications

Answer 4

MAO inhibitors (hyperthermia & CV collapse)
Caution in epilepsy & peptic ulcer disease
PPI if with aspirin or nsaids

Question 5

SSRI adverse effects

Answer 5

8S
Size, Sick, Serotonin syndrome, Sexual dysfunction, Stomach upset, Stress, Suicide, Sleep difficulty, Sodium (low)

Question 6

Serotonin syndrome

Answer 6

Triad of autonomic hyperactivity, altered mental state and neuromuscular excitation

Question 7

What is a SNRI & example

Answer 7

Serotonin & Noradrenaline Reuptake Inhibitors

Venlafaxine, Duloxetine

Question 8

Use of SNRI

Answer 8

When SSRI ineffective for depression
Generalised anxiety disorder (venlafaxine)

Question 9

Noradrenergic & Specific Serotonin Antidepressant example

Answer 9

Mirtazapine

(Alpha 2 adrenoreceptor antagonists)

Question 10

MAO - I

Answer 10

Monoamine oxidase inhibitors
Ipronoazid, Selegiline

Question 11

Tricyclic antidepressants examples

Answer 11

Amitriptyline, imipramine, lofepramine

Question 12

Tricyclic contraindications

Answer 12

Recent MI or Arrhythmia
Manic phase
Severe liver disease
Epilepsy
other anticholineric drugs, alcohol & adrenaline
Lidocaine

Question 13

Adverse effects of tricyclics

Answer 13

Muscarinic blocking (dry mouth, blurred vision, constipation)
A-adrenergic blocking (postural hypotension)
Noradrenaline uptake block in heart (arrhythmias)
Histamine blocking - sedation
Weight gain

Question 14

Categories of antidepressant

Answer 14

SSRI
SNRI
NaSSA
MAO-I
Tricyclics

Question 15

Mood Stabilisers

Answer 15

Lithium
Carbamazepine
Sodium valproate
Lamotrigine

Question 16

Anxiolytic drugs =

Answer 16

Reduced anxiety
Can induce sleep in high doses

Question 17

Hypnotic drug =

Answer 17

Induces sleep. Can calm in low doses

Question 18

Examples of anxiolytics/ tranquillisers

Answer 18

Benzodiazepines
Z drugs

Question 19

Benzodiazepines examples

Answer 19

Midazolam, lorazepam, diazepam, chlordiazspoxide

Question 20

What do benzos do

Answer 20

Enhance inhibitors neurotransmitter gaba by increasing frequency of chloride channels. Used in insomnia, anxiety, alcohol withdrawal, acute main or psychosis (sedation)

Question 21

Z drug

Answer 21

Zopiclone

Question 22

Typical antipsychotics

Answer 22

Haloperidol, molindone, chlorpromazine

Question 23

What do typical antipsychotics do

Answer 23

Dopamine cholinergic adrenergic and histaminergic antagonists

Question 24

Atypical antipsychotics

Answer 24

Olanzapine clozapine aripiprazole
Rispiridone
Quetiapine