Psych

Question 1

Bupropion class, MOA, route/pharmaco

Answer 1

Atypical antidepressant (tetracyclic)
MOA: dopamine and NE receptor uptake inhibitor (increases dopamine and NE)
Route/Pharmacokinetics: Oral (IR and ER), MORE!!!

Question 2

Mirtazapine class, MOA, route/pharmaco

Answer 2

Atypical antidepressant
MOA: unknown (increases serotonin and NE)
Route/pharmaco: MORE!!!

Question 3

Methylphenidate class, MOA, route/pharmaco

Answer 3

Stimulant
MOA: blocks reuptake of NE/dopamine; increases NE and dopamine (sympathomimetic). Allows increased dopaminergic and noradrenergic activity in prefrontal cortex
Route/pharm: Oral tabs/capsule, oral solution, transdermal patch. Liver metabolism

Question 4

Amphetamine class, MOA, route/pharm

Answer 4

Stimulant
MOA: blocks reuptake of NE/domapine; increases NE and dopamine (sympathomimetic). Allows increased dopaminergic and noradrenergic activity in prefrontal cortex
Route/pharm: oral tabs/capsules, oral solution. MORE!!!!!

Question 5

Combination (dextroamphetamine/amphetamine) - lesdexamfetamine

Answer 5

CLARIFY IF THIS IS THE COMBINATION DRUG SHE IS TALKING ABOUT

Question 6

Atomoxetine class, MOA, route/pharm

Answer 6

Non-stimulant
MOA: selective NE reuptake inhibitor (weakly increases NE and dopamine in prefrontal cortex compared to stimulants)
Route/pharm: Oral capsule, CYP2D6, MORE!!!!!!

Question 7

Clonidine

Question 8

Haloperidol

Question 9

Chlorpromazine

Question 10

Clozapine

Question 11

Risperidone

Question 12

Olanzapine

Question 13

Quetiapine

Question 14

Ziprasidone

Question 15

Aripiprazole

Question 16

Lurasidone

Question 17

Lithium

Question 18

Valproic acid

Question 19

Carbamazepine

Question 20

Lamotrigine

Question 21

MAOI

Question 22

Bupropion indications and contraindications

Answer 22

Indication: MDD, seasonal affective disorder, SMOKING CESSATION. Off-label: ADHD, sexual dysfunction, bipolar depression
Contraindications: avoid in pts w seizures or ED (especially purging), electrolyte abnormalities, alcohol withdrawal w seizure hx, avoid if comorbid anxiety disorder (can worsen anxiety because no serotonergic activity), caution with MAOIs

Absolute contraindication: history of bulimia nervosa (history of purging)

Question 23

Bupropion SE

Answer 23

Serious/rare SE: seizure, suicidal thoughts
Common SE: agitation/mania, insomnia, headache, N/V, tremor, tachycardia, dry mouth, weight loss

Question 24

Facts about Bupropion

Answer 24

Facts: not as effective as stimulants for ADHD. Good choice for MDD+ADHD. not associated with weight gain or sexual side effects, not concerned for serotonin syndrome, can increase energy.

Question 25

Mirtazapine indications and contraindications

Answer 25

Indications: MDD, anxiety, SLEEP DISORDERS - MORE!!!!! Contraindications: MORE!!!!!

Question 26

Mirtazapine SEs

Answer 26

Common: weight gain, sedation, anti-nausea, appetite increase Serious: serotonin syndrome, neutropenia, agranulocytosis

Question 27

Mirtazapine facts

Answer 27

Good for weight gain, tx of insomnia, useful w appetite loss and GI disturbances, good with geriatric population, lower incidence of sexual side effects. Weight gain/sedating SE reduced w increased dose

Question 28

Methylphenidate indications and contraindications

Answer 28

Indications: ADHD, narcolepsy. Off-label: obesity, tx-resistant MDD Contraindications: avoid use with MAOI for 14days, HTN, glaucoma, Tourette's or tics (or FH), uncontrolled thyroid disorder, cardiac abnormalities, peripheral vasculopathy (Raynaud's)

Question 29

Methylphenidate SEs

Answer 29

Specific ones???

Question 30

SEs for Stimulants

Answer 30

decreased appetite, insomnia, headaches, GI upset, irritability/moodiness, increased HR/BP, priapism after prolonged time on drug, dependency/abuse, psychosis, mania, aggression, Tourette syndrome, MI, stroke, anorexia, nervousness, dry mouth

Question 31

Methylphenidate facts

Answer 31

Causes fewer SE than amphetamine

Question 32

SE/Contraindication Warnings for all Stimulants:

Answer 32

SE: seizures (lowers seizure threshold), growth inhibition or weight loss, potential to cause psychosis or aggression, worsening or new-onset Tourette's or tic disorder, cardiac events (obtain EKG prior). Contraindications: pregnancy and lactation, bipolar dx, psychosis, cardiac dx

Question 33

Amphetamine indications and contraindications

Answer 33

Indication: ADHD, narcolepsy, obesity-short term. Off-label: tx-resistant MDD Contraindications: avoid use with MAOI for 14days, HTN, glaucoma, Tourette's or tics (or FH), uncontrolled thyroid disorder, cardiac abnormalities, peripheral vasculopathy (Raynaud's)

Question 35

Atomoxetine indications and contraindications

Answer 35

Indications: ADHD (>6yrs) Contraindications: MORE!!!!!!!!

Question 36

Atomoxetine SEs

Question 37

Ramelteon

Question 38

Doxylamine

Question 39

Diphenhydramine

Question 40

Zolpidem

Question 41

Zaleplon

Question 42

Eszopiclone

Question 43

Alprazolam

Question 44

Lorazepam

Question 45

Clonazepam

Question 46

Diazepam

Question 47

Temazepam