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Pharmacology > Psych > Flashcards

Psych Flashcards

1
Q

Bupropion class, MOA, route/pharmaco

A

Atypical antidepressant (tetracyclic)
MOA: dopamine and NE receptor uptake inhibitor (increases dopamine and NE)
Route/Pharmacokinetics: Oral (IR and ER), MORE!!!

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2
Q

Mirtazapine class, MOA, route/pharmaco

A

Atypical antidepressant
MOA: unknown (increases serotonin and NE)
Route/pharmaco: MORE!!!

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3
Q

Methylphenidate class, MOA, route/pharmaco

A

Stimulant
MOA: blocks reuptake of NE/dopamine; increases NE and dopamine (sympathomimetic). Allows increased dopaminergic and noradrenergic activity in prefrontal cortex
Route/pharm: Oral tabs/capsule, oral solution, transdermal patch. Liver metabolism

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4
Q

Amphetamine class, MOA, route/pharm

A

Stimulant
MOA: blocks reuptake of NE/domapine; increases NE and dopamine (sympathomimetic). Allows increased dopaminergic and noradrenergic activity in prefrontal cortex
Route/pharm: oral tabs/capsules, oral solution. MORE!!!!!

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5
Q

Combination (dextroamphetamine/amphetamine) - lesdexamfetamine

A

CLARIFY IF THIS IS THE COMBINATION DRUG SHE IS TALKING ABOUT

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6
Q

Atomoxetine class, MOA, route/pharm

A

Non-stimulant
MOA: selective NE reuptake inhibitor (weakly increases NE and dopamine in prefrontal cortex compared to stimulants)
Route/pharm: Oral capsule, CYP2D6, MORE!!!!!!

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7
Q

Clonidine

A
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8
Q

Haloperidol

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9
Q

Chlorpromazine

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10
Q

Clozapine

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11
Q

Risperidone

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12
Q

Olanzapine

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13
Q

Quetiapine

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14
Q

Ziprasidone

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15
Q

Aripiprazole

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16
Q

Lurasidone

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17
Q

Lithium

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18
Q

Valproic acid

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19
Q

Carbamazepine

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20
Q

Lamotrigine

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21
Q

MAOI

A
22
Q

Bupropion indications and contraindications

A

Indication: MDD, seasonal affective disorder, SMOKING CESSATION. Off-label: ADHD, sexual dysfunction, bipolar depression
Contraindications: avoid in pts w seizures or ED (especially purging), electrolyte abnormalities, alcohol withdrawal w seizure hx, avoid if comorbid anxiety disorder (can worsen anxiety because no serotonergic activity), caution with MAOIs

Absolute contraindication: history of bulimia nervosa (history of purging)

23
Q

Bupropion SE

A

Serious/rare SE: seizure, suicidal thoughts
Common SE: agitation/mania, insomnia, headache, N/V, tremor, tachycardia, dry mouth, weight loss

24
Q

Facts about Bupropion

A

Facts: not as effective as stimulants for ADHD. Good choice for MDD+ADHD. not associated with weight gain or sexual side effects, not concerned for serotonin syndrome, can increase energy.

25
Q

Mirtazapine indications and contraindications

A

Indications: MDD, anxiety, SLEEP DISORDERS - MORE!!!!!
Contraindications: MORE!!!!!

26
Q

Mirtazapine SEs

A

Common: weight gain, sedation, anti-nausea, appetite increase
Serious: serotonin syndrome, neutropenia, agranulocytosis

27
Q

Mirtazapine facts

A

Good for weight gain, tx of insomnia, useful w appetite loss and GI disturbances, good with geriatric population, lower incidence of sexual side effects. Weight gain/sedating SE reduced w increased dose

28
Q

Methylphenidate indications and contraindications

A

Indications: ADHD, narcolepsy. Off-label: obesity, tx-resistant MDD
Contraindications: avoid use with MAOI for 14days, HTN, glaucoma, Tourette’s or tics (or FH), uncontrolled thyroid disorder, cardiac abnormalities, peripheral vasculopathy (Raynaud’s)

29
Q

Methylphenidate SEs

A

Specific ones???

30
Q

SEs for Stimulants

A

decreased appetite, insomnia, headaches, GI upset, irritability/moodiness, increased HR/BP, priapism after prolonged time on drug, dependency/abuse, psychosis, mania, aggression, Tourette syndrome, MI, stroke, anorexia, nervousness, dry mouth

31
Q

Methylphenidate facts

A

Causes fewer SE than amphetamine

32
Q

SE/Contraindication Warnings for all Stimulants:

A

SE: seizures (lowers seizure threshold), growth inhibition or weight loss, potential to cause psychosis or aggression, worsening or new-onset Tourette’s or tic disorder, cardiac events (obtain EKG prior).
Contraindications: pregnancy and lactation, bipolar dx, psychosis, cardiac dx

33
Q

Amphetamine indications and contraindications

A

Indication: ADHD, narcolepsy, obesity-short term. Off-label: tx-resistant MDD
Contraindications: avoid use with MAOI for 14days, HTN, glaucoma, Tourette’s or tics (or FH), uncontrolled thyroid disorder, cardiac abnormalities, peripheral vasculopathy (Raynaud’s)

34
Q
A
35
Q

Atomoxetine indications and contraindications

A

Indications: ADHD (>6yrs)
Contraindications: MORE!!!!!!!!

36
Q

Atomoxetine SEs

A
37
Q

Ramelteon

A
38
Q

Doxylamine

A
39
Q

Diphenhydramine

A
40
Q

Zolpidem

A
41
Q

Zaleplon

A
42
Q

Eszopiclone

A
43
Q

Alprazolam

A
44
Q

Lorazepam

A
45
Q

Clonazepam

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46
Q

Diazepam

A
47
Q

Temazepam

A

Pharmacology (4 decks)

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