Psych Flashcards
What is Deprivation of Liberty Safeguards(DoLS)?
Procedure prescribed in law when it is necessary to deprive of their liberty a resident or patient who lacks capacity to consent to their care and treatment in order to keep them safe from harm.
What are the 3 core syx of depression
- Low mood
- Anhedonia
- Anergia
Biological manifestastions of depression
- Fatigue/sleep distrubance
- Appetite/weight change
- Low libido
Cognitive features depression
- Memory impairment
- Beck’s triad
- Hoplessness
- Worthlessness
- Helplessness
Depression diagnosis criteria timeframe
Syx lasting at least 2 weeks
Depression levels of severity
Mild: 2 or 3 core syx + 2 others; can continue w most dialy activities
Moderate: 2 or 3 core syx + 3-4 others; difficulty with social acitivities and day to day functioning
Severe: 3 core syx + 4 or more others; major impact on daily function
Things to consider when diagnosing depression
- Organic causes
- FBC
- TFT
- Bipolar disorder
- Previous mood elevation - (hypo)mania
High risk features of completing suicide attempt
- Careful planning
- Acts in anticipation
- Precautions to prevent discovery
- Suicide note
- Violent method
Depression Ix
Depression mx
Bio
- Antidepressants
- SSRI - sertraline, fluoxetine, citalopram, etc.
- SNRI - venlafaxine
- Augmentation therapy
- Diff class antidepr // add lithium
- ECT
Psycho
- Self help
- CBT
- Interpersonal therapy
Social
- Finance
- Relationships
- Occupation
–
Mild- moderate
- Low intensity psychological intervention
- Guided self-help
- Computerised CBT
- Structured group physical activity programme
- Group CBT
- +/- medication
- 2 week follow up
Moderate - severe
- High intensity psychological intervention
- Individualised CBT
- Interpersonal therapy
- Medication
Classes of antidepressants and examples of each
Selective serotoni receptor inhibitors (SSRIs)
- Sertraline
- Fluoxetine
- Citalopram
- Escitalopram
Serotonin and noradrenaline receptor inhibitors (SNRIs)
- Venlafaxine
- Deloxetine
Tricyclic anti-depressants (TCAs)
- Amitriptyline
- Notriptyline
Monoamine oxidase inhibitors (MAOis)
- Phenelzine
Noradrenergic and specific serotonergic antidepressants (NaSSA)
- Mirtazapine
Reversible inhibitors of monoamine oxidase type A (RIMAs)
- Moclobemide
How long should pts continue antidepressants post-recovery for optimum prognosis?
6 months
SSRI side effects
- GI syx
- GI bleeding (+PPI)
-
Hyponatraemia
- confusion, dizziness and weakness
How long does it take to stop an SSRI?
Withdraw gradually over 4 weeks
*Except fluoxetine due to its longer half life
SSRI discontinuation syndrome
- Anxiety
- GI symptoms
- Electric shock sensations
- Dizziness
SSRIs and pregnancy
Avoid unless benefits outweigh risks
- 1st trimester - small increased risk of congenital heart defects
- 3rd trimester - can result in persistent pulmonary hypertension of the newborn
Indications for Sertraline
Unstable angina or recent MI
How to swap from Fluoxetine to different SSRI?
Stop fluoxetine then 1 week wash out period (due to long half life) then start gradually
Citalopram and Escitalopram SEs
ventricular arrhythmias including torsade de pointes
Serotonin syndrome
- confusion
- agitation
- muscle twitching
- sweating
- shivering
- diarrhoea
SNRI SEs
- Hypertension
TCA side effects
- Overflow urinary incontinence
- Prolonged QT on ECG
MAO-I Precaution
Avoid cheese (tyramine) –> hypertensive crisis
What (non-psych) drug can cause low mood?
Beta blockers
Seasonal affective disorder
depression which occurs predominately around the winter months
SAD Mx
Treated the same way as depression
CBT explanation
CBT is a form of talking therapy based on the concept that our thoughts, emotions, and actions are interrelted, and that negative thoughts and feelings can trap you in a negative cycle.
CBT aims to help us deal with problems by approaching them from a bird’s eye view and breaking them down into smaller parts to change the way we think and behave
Normal grief reaction presentation
- Low mood
- Psuedohallucinations
- false sensory perception in the absence of external stimuli when the affected is aware that they are hallucinating
Last up to 6months post loss
What is CBT used for?
- Depression
- Anxiety
- OCD
- Eating disorders
- PSTD
Anxiety differentials
What can be mistaken for anxiety?
Hyperthyroidism
- Abdo pain
- Palpitations
- Agitated and fidgety
- Difficultly sleeping
- Affected concentration
Anxiety Ix
MSE
GAD7
TFTs
Generalised anxiety disorder
Regular and uncontrolled (can be triggered by anything/ have no trigger) anxiety for >= 6 months.
GAD Psychological presentation
- Anxiety
- Fear
- Impaired concentration
- Irritability
GAD Physical presentation
- Tremors
- Palpitations
- Loose stools
GAD Mx
Bio
- SSRI - sertraline specifically
- higher dose than for depression
- Try a 2nd SSRI or SNRI as 2nd line
- Benzodiazepines
- Acute use for mx bad bouts of GAD
- Beta blockers
- Reduce physical syx, e.g., tremor
- CI in asthma/diabetes
- Reduce physical syx, e.g., tremor
Psycho
- CBT
- Mindfullness
- Psychoeducation
Social
- Advice on stress mx
- Advice on coping mechanisms
- e.g., drug & alcohol
Acute anxiety (situation) Mx
Short prescription of Benzodiazepines
Panic disorder (panic attacks) features
- Rapid-onset severe anxiety
- Impending sense of doom
- Resolves rapidly
- Palpitations + tachypnoea
Panic disorder Mx
Bio
- SSRIs
Psycho
- CBT
Social
- Psychoeducation
- Breathing exercises
- Support groups
Acute stress disorder
Acute stress reaction that occurs in the 4 weeks after a traumatic event
Post traumatic stress disorder
Stress reaction that develops 4 weeks following traumatic event. Symptoms present for >1 month.
PTSD features
- re-experiencing: flashbacks, nightmares, repetitive and distressing intrusive images
- avoidance: avoiding people, situations or circumstances resembling or associated with the event
- hyperarousal: hypervigilance for threat, exaggerated startle response, sleep problems, irritability and difficulty concentrating
- emotional numbing - lack of ability to experience feelings, feeling detached
PTSD Mx
Bio
- Venlafaxine (SNRI)
- or SSRI
- Risperidone in severe cases
Medication is not 1st line
Psycho
- Trauma-focussed CBT
- Eye movement desensitisation and reprocessing (EMDR)
- More severe cases
Social
*
Obsessive compulsive disorder
Recurrent obsessional thoughts or compulsive acts are developed
Obsessions: thoughts/images that are distressing, unwanted and intrusive that are recognised as own thoughts
Compulsions: repetitive behaviors or mental acts that a person feels driven to perform in response to an obsession
OCD Mx
Psycho
- CBT including exposure and response prevention
Bio
2. SSRI
- Quickly increased to high dose
- To continue for 12 months after pt goes into remission
- Clomipramine or alt SSRI (if first SSRI ineffective after 12 weeks)
Agoraphobia
- Fear of being unable to escape to a safe place
- Often end up housebound
Social phobia features
- Fear of being scrutinised/judged
- People noticing you blush
- Can tolerate large, anonymous crowds
- Dislike intimate gathering
Type 1 vs Type 2 Bipolar disoder
Type 1
Mania + depressive episodes
Type 2
Hypomania + depressive episodes
Manic episode presentation
Mania lasts for at least 7 days
- Feelings of euphoria
- Hallucinations and/or delusions
- Predisposition to risky or reckless behaviour
- Mutism
- Severely manic pts
Mania Mx
From primary care
- Urgent referral to community mental health team
Psych
- Olanzapine
- Useful in acute mania
- Long term prophylaxis for bipolar affective disorder
- Clonazepam &/or Lorazepam
- Fast onset of action
- Tranquilising effect
*Psychological therapy not usually offered to manic pts in the acute phase
Manic patients risk of depressive episode in future
>90%
Auditory hallucinations in Schizophrenia (3)
- Thought echo
- Hears own thoughts as if spoken aloud to them
- 3rd person voices
- People talking about them from 3rd person
- Running commentary
- Voice narrating what they are saying
Hypomania presentation
Typically lasting 3-4 days
- Does not interefere majorly with day to day
- Euphoric
- Impulsive behaviour
- Feels doesn’t need sleep/far less sleep
- Irritability
- Flight of ideas
Hypomania mx
Low risk
- Routine referral to CMHT
High risk
- Urgent referral to CMHT
Bipolar disorder Mx
- Mood stabilisers
- Lithium
- Alt Sodium Valproate
- Address co-morbidities
- 2-3x incr risk diabetes, CVD, COPD
Lithium monitoring
Lithium levels should be checked 12 hours post-dose
- One week after starting treatment/after dose change
- Weekly until the levels are stable
- Once levels are stable, measure every 3 months
+ every 6/12:
- U&Es
- TFTs
Lithium SEs
- Hypothyroidism
- Renal impairment
- Preceipitation of a relapse if suddenly discontinued
Lithium overdose presentation
- Coarse tremors
- GI disturbance
- Ataxia
- (white pills)
Lithium and pregnancy
First trimester exposure associated with Ebstein’s anomaly (a serious cardiac anomaly)
Lithium and NSAIDs
NSAIDs can increase lithium levels in the blood resulting in an increased risk for serious adverse effects like confusion, tremor, slurred speech, and vomiting
Sodium Valproate SEs
- N+V
- Diarrhoea
- Movement disorder
Sodium valproate congenital risks
- cleft palate
- spina bifida
- Neural tube defects
Mx of manic/hypomanic pts on antidepressants
Consider stopping the antidepressant and start antipsychotic therapy
Psychosis differentials
- Acute (episode)
- Transient, resolves
- Organic
- Drugs
- Delirium
- Medication
- Steroids
- Affective
- Severe depression
- Mania
- Personality disorders
- Schizoaffective
- Schizotypal
- Delusional disorder
- Only have delusions
First episode psychosis Ix and Mx
Ix
- Take a detailed history
- Drug use
- FHx
- Perform exam and ix
- Urine drug screen
- Obtain collateral hx
Mx
- Consider section 5(2)
- Refer to psych team
- Commence medication
- For acute agitation: Lorazepam
- Antipsychotic: Atypical but NOT Clozapine
- Aripiprazole 10mgOD, or Olanzapine 10mg nocte
- Education & support
Baby blues
Tearful & emotionally labile after giving birth
Post natal depression screen
Ask 2 depression identification Qs (low mood & anhedonia), if +ve to one ->
Edinburgh postnatal depression scale
PND Mx
- CBT
- SSRI
- F/U w GP
- Home visits from community midwives
Puerperal psychosis onset
Occurs in first 3 weeks post natal with acute onset
Puerperal psychosis presentation
- Elevated mood
- Sleeping less/not sleeping
- Delusions
- Often grandiose
Schizophrenia explanation
Characterised by break down of thought process, contact with reality, and emotional responsiveness
Schizophrenia classification (4)
- Paranoid (most common)
- Prominent delusions & hallucinations
- Dominated by sense of anxiety that something bad will happen
- Hebephrenic
- Disorganised
- Chaotic mood
- ‘child-like’ shallow & inappropriate affect
- Catatonic
- Psychomotor disturbance
- Simple
- Only negative features, e.g., social withdrawal and blunted affect
Schneider’s first rank syx
- Auditory hallucinations
- Abnormal thoughts
- Delusions
Abnormal thoughts in Schizophrenia (3)
- Thought insertion
- Thoughts have been inserted into their brain
- Thought withdrawal
- Thoughts are being stolen from them
- Thought broadcasting
- Other people can see/hear what they are thinking
Definition of delusion
False, fixed belief held despite conflicting evidence.
Development of Schizophrenia
Prodrome -> Acute phase -> Chronic phase
Prodrome
- Social withdrawal
- Loss of interest in work and relationships
Acute phase
- Delusions
- Hallucinations
- Thought interference
Chronic phase
- Apathy
- Blunted affect
- Social withdrawal
- Anhedonia
- Poverty of thought
Prevalence of schizophrenia in general population
1%
Risk of schizophrenia in 1) child (if 1 parent has it), 2) twin
1) 10%
2) 50%
Schizophrenia RFs
FHx
- monozygotic twin has schizophrenia = 50%
- parent has schizophrenia = 10-15%
- sibling has schizophrenia = 10%
- no relatives with schizophrenia = 1%
Others
- Black Caribbean ethnicity - RR 5.4
- Migration - RR 2.9
- Urban environment- RR 2.4
- Cannabis use - RR 1.4
Schizophrenia Mx
Schizophrenia mx
Bio
- Antipsychotics
Psycho
- CBT
- Family therapy
Social
- Social skills training
- Education
- Benefits
- Housing
Treatment resistant Schizophrenia
Failure to respond to 2 or more antipsychotics, at least 1 of which is atypical. Each given at therapeutic dose for at least 6 weeks.
Treatment resistant Schizophrenia Mx
Clozapine
- Weekly blood tests
- Risk of agranulocytosis
- Decreased leukocytes
- Counsel about taking infyx syx seriously
- Risk of agranulocytosis
*reduces seizure threshold
What is prodromal schizophrenia?
earliest stage of schizophrenia
(not experience by everyone)
Features of prodromal schizophrenia
- Nervousness
- Anxiety
- Depression
- Difficulty concentrating
- Excessive worrying
Typical antipsychotic mechanism
Dopamine antagonist
Typical antipsychotic SEs
Extra pyrimidal side effects
(mimics parkinsons)
- Acute dystonia
- suddenly v painful contractions of parts of body
- oculogyric crisis - deviation of eyes and repeated blinking
- Procyclidine helps treat ^
- Tardive dyskinesia
- Often develops with long term use
- Lip smacking, sticking tongue out, difficulty swallowing, excessive blinking
- Parkinsonism
- Akathisia
- restlessness
Typical antipsychotics examples
- Haloperidol
- Chlorpromazine
- Zuclopenthixol decanoate
Atypical antipsychotics examples
- Olanzapine
- Quetiapine
- Clozapine
- Risperidone
- Aripiprazole
Atypical antipsychotics mechanism
Affect dopamine, serotonin, histamine and adrenergic receptors
Atypical antipsychotic SEs
Metabolic
- Weight gain
- Dyslipidaemia
- Hypercholesterolaemia
- Hyperprolactinaemia
Missed Clozapine
If missed for >48 hours, dose will need to be retitrated again slowly
Starting Clozapine after a break of >48 hours,can make side effects worse, such as blood pressure changes, drowsiness and dizziness