Psych

Question 1

positive symptoms of schizophrenia

Answer 1

suspiciousness, delusions, hallucinations, conceptual disorganization

Question 2

negative symptoms of schizophrenia

Answer 2

flat affect, alogia, anhedonia, avolition

Question 3

cognitive symptoms of schizophrenia

Answer 3

impaired attention, impaired working memory, impaired executive function

Question 4

monitoring for atypical antipsychotics

Answer 4

BG/hgbA1c
LFTs
neurologic function
serum cholesterol
weight
QTC

Question 5

teaching for atypical antipsychotics

Answer 5

may take several weeks before full effects
may need to taper off
avoid alcohol

Question 6

atypical antipsychotics examples

Answer 6

aripiprazole (Abilify)
lurasidone (Latuda)
olanzapine (Zyprexa)
Quetapine (Seroquel)
Risperidone (Risperdal); Paliperidone (Invega)
Ziprasiidone (Geodon)

Question 7

atypical antipsychotics least likely to cause weight gain

Answer 7

abilify (aripiprazole)
lurasidone (latuda)
zipradisone (geodon)

Question 8

atypical antipsychotics oral disintegrating tab vs no disintegrating formulations

Answer 8

peak serum concentration occurs slower in oral disintegrating tabs

Question 9

atypical antipsychotics that need to be taken with food

Answer 9

lurasidone (latuda)

ziprasidone (geodon)

Question 10

paliperidone is a metabolite of which atypical antipsychotic?

Answer 10

respiridone

Question 11

common AEs of atypical antipsychotics

Answer 11

sedation, weight gain, extrapyramidal effects, dizziness, poor thermoregulation, glucose dysregulation, black box warning for increased risk w dementia, QT prolongation

Question 12

akathisia

Answer 12

restlessness

can increase risk for suicide

Question 13

patho of depression

Answer 13

changes in monoamine neurotransmitters including NE, 5-HT, and DA

Question 14

symptoms of serotonin syndrome

Answer 14

euphoria, DROWSINESS, HYPERACTIVE REFLEXES, rapid muscle contractions, dizziness, SWEATING, hyperthermia, shivering,, hyperactive bowel sounds, death

Question 15

AEs of SSRIs

Answer 15

serotonin syndrome, nausea, drowsiness/dizzines, HA/tremor, black box warning

Question 16

SSRI interactions

Answer 16

other drugs containing serotonin

alcohol

CYP2D6

Question 17

optimal dosing of escitalopram (Lexapro)

Answer 17

20 mg daily

> 20mg does not have effect

Question 18

which SSRI has significant GI side effects?

Answer 18

paroxetine

Question 19

SSRIs to avoid d/t CYP2D6 pathway

Answer 19

paroxetine (paxil)
fluoxetine (prozac)

citalopram or sertraline least likely to have interactions

Question 20

SSRI with longest half life

Answer 20

fluoxetine

good for pts who are poorly adherent or have had trouble w discontinuation previously

Question 21

SSRI least likely to cause weight gain

Answer 21

paroxetine

Question 22

SNRI examples

Answer 22

duloxetine (cymbalta)
venlafaxine (effexor XR)
desvenlafaxine (prestiq)

Question 23

AEs of TCAs

Answer 23

dr mouth, dry eyes, blurred vision, sun sensitivity, sedation, glucose dysregulation

Question 24

TCA examples

Answer 24

amitriptyline
nortriptyline
doxepin (sinequan)
mirtazapine (remeron)

Question 25

trazodone moa

Answer 25

increases serotonin and norepinephrine to cause antidepressive effects used off label for sleep

Question 26

trazodone AEs

Answer 26

sedation, orthostasis, dry mouth, nausea less likely to cause sexual dysfunction, agitation, and weight changes than other antidepressants

Question 27

vilazodone (viibryd) MOA

Answer 27

SSRI and 5HT-1A partial agonist

Question 28

lithium AEs

Answer 28

sodium dysregulation, dizziness/drowsiness, nausea

Question 29

benzodiazepines MOA

Answer 29

produce CNS depression by enhancing GABA-benzidiazepine receptor compless act at the level of the limbic, thalamic, hypothalamic regions of CNS

Question 30

what pregnancy category are benzos?

Answer 30

D - may cause congenital malformations in first trimester

Question 31

benefits of buspirone (buspar) for anxiety

Answer 31

no impaired psychomotor, sedation, dependence, or decreased concentration

Question 32

MOA of eszopiclone (lunesta) & zolpidem (ambien)

Answer 32

non-benzodiazepine hypnotics selectively bind to GABA receptors to induce sleepiness

Question 33

tamazepam (restoril) use

Answer 33

benzodiazepine indicated for sleep

Question 34

AEs of stimulants

Answer 34

upset stomach, insomnia, HA, rebound symptoms, stimulant-induced sleep disturbances

Question 35

atomexetine (strattera) MOA & use

Answer 35

SNRI approved for ADHD maintenance