PSYC1002 #2 Flashcards
From middle of sleep lecture just before the start of behaviour
What does the suprachiasmatic nucleus control and do? How long does the human clock go for and how does the clock work?
Are sleep and wakefulness cycles affected by light?
Controls release of hormone melatonin from pineal gland
o Its activity acts as a clock and keeps track of the time of day tells body what time it is
o In humans, this clock goes for a total of 25 hours it is a bit slow but when light hits your face it resets
o Takes a few days for the clock to be reset properly easier to set your clock later than earlier so it’s easier to get over jetlag from a western country than from an eastern country
o Sleep and wakefulness cycles are not affected by lack of light
What does melatonin do and signal? When do levels of melatonin in blood peak? What is the difference in melatonin between young adults and old people?
• Melatonin signals night time to whole body
o Levels of melatonin level in blood from 12pm-6pm are flat but peaks at 12am and then goes back down in the morning
o The rise in melatonin is a cue for the brain to be going to sleep
o Young adults release more melatonin during the evening than older people
What does adenosine do when we’re awake
Builds up in brain
-Being awake for longer increases amount of adenosine
o Adenosine increases sleepiness (sleep pressure desire to go to sleep based on how long you’ve been awake) by inhibiting alertness centres (especially Ach in pons) and stimulating sleep centres (pre-optic area)
o Brain uses accumulation of adenosine level as an indicator of how long the person has been awake for
How is adenosine produced?
by brain as by-product of activities
How do you get rid of adenosine?
Through sleep
What does caffeine do?
Blocks adenosine receptors
What happens during an all-nighter
o An all-nighter means that melatonin levels go back down in the morning, but adenosine levels keep accumulating so feel less tired in the morning of an all-nighter but deadly tired the next night
Where is the pre-optic area?
In the anterior hypothalamus
What does destruction of the pre-optic area do?
Cause insomnia
What does stimulation of the pre-optic area do?
Induce sleep
What neurotransmitter do neurons in the pre-optic area contain and what does it do?
GABA- this neurostransmitter inhibits Ach, 5HT and NA arousal systems in brainstem so that you can go to sleep
How do you measure activity when someone is asleep?
EEG
What is the electrical activity in our brains when we’re awake?
• When we’re awake, the electrical activity in our brains is of high frequency but with small fluctuations
How is sleep characterised, and how is it achieved?
• Sleep is characterised by slow rhythmic patterns of electrical activity in the brain (slow-wave sleep, the 4th cycle of sleep).
o Activity slows down but fluctuations in electrical activity get larger and slower
Neurons around cortex are being synchronised
Synchronisation of neurons is achieved by the thalamus
• Thalamus can coordinate unification of brain as it is bidirectionally connected to the cortex can communicate with the cortex and cortex can communicate to it
What is Rapid Eye Movement sleep?
o At multiple times through the night, the brain waves become desynchronised, just like when we’re awake
o During these periods, the eyes dart back and forth
What happens if woken during REM
o If woken during REM, typically report dreams- associated with visual dreams
More dreams during REM than other cycles
What is REM caused by?
o REM sleep caused by neurons in Pons that contain acetylcholine and stimulate neurons in the thalamus, which project to the visual cortex
Using fMRI- during REM, various areas become very active: visual regions at back of brain, motor regions, and limbic system (especially amygdala and cingulate, the emotional parts (which is why our dreams are so emotional), even more active than when we’re awake)
Suppression of particular regions of frontal lobes (lateral prefrontal cortex; important for logic, reasoning and self control)- which is why you have no self-control in dreams and do things you normally wouldn’t do in dreams
Can we move during REM sleep? Why/why not?
o During REM sleep, we are paralysed
Ach neurons in pons stimulate neurons in medulla, which ultimately inhibit motor neurons in the spinal cord (paralysis)
Destruction of these neurons in medulla causes animal to become very active during REM sleep (no longer paralysed)
Motor signals to your eyes only thing that isn’t paralysed during REM sleep
This is why sometimes paralysed for 30 seconds in morning- REM sleep has yet to be turned off
Describe typical sleep cycle
- First few hours of sleep is deep slow wave sleep
* After 40min-1h, REM sleep may have a cycle- REM occurs more frequently in the morning
Does REM increase during the night and life span?
What does alcohol do to REM sleep?
- Amount of REM increases during the night, but decreases across life span (The foetus has a lot of REM: 50% for newborns, decreasing to 20% in adults.)
- Alcohol reduces REM sleep (including in utero)
Why is a reward useful?
o Motivation to engage in a particular behaviour o Animals (including humans) will act in order to receive some reward
What did Olds and Milner do?
o Electrical self-stimulation of the brain
Olds and Milner accidently implanted an electrode into the medial forebrain bundle ( a bundle of noradrenaline and dopamine fibres travelling from brainstem to forebrain)
Their rat kept returning to place where it had received electrical brain stimulation
O and M went on to show that rats with electrode in mfb would readily learn to perform many acts in order to receive electrical stimulation
If allowed, rats would do nothing else but press bar
• Would prefer to starve or even tolerate shocks through floor in order to continue self-stimulating
• The simulation has become an addiction
What axons are involved in rewarding effect? What drugs influence it and how?
• Dopamine axons in mfb make greatest contribution to rewarding effect of electrical stimulation
o Effects greatly reduced by destruction of dopamine fibres
o Many addictive drugs (e.g. amphetamines, cocaine) directly boost release of dopamine in mfb
o Other drugs (eg heroin) indirectly increase dopamine release
Rats will work (e.g. bar press) in order to receive injections of amphetamines or opiates into nucleus accumbens
o VTA- full of opium receptors which heroin and morphine directly influence
o Food and sex operate on this structure of the brain
Are the right and left hemispheres responsible for their respective sides or opposite sides?
Opposite sides- right hemisphere receives from left side of body whilst left hemisphere receives from right side of body