PSY2206 All weeks Flashcards
How does MR work?
When a magnetic field changes over time with the rate of radio waves and is applied to hydrogen atoms, they respond (resonate) when there is a measurable magnetic signal. MR signal is only obtained if hydrogen atoms are aligned in parallel, not when they have random orientations. Hydrogen atoms can be aligned by putting them in a very large electromagnet.
Why is fMRI better than MRI?
measures brain activity as well as structure.
How does fMRI measure brain activity?
The Blood Oxygen Level Dependent (BOLD) effect- Areas of the brain that are more active receive more oxygenated blood than they use. Hence, they contain less deoxygenated haemoglobin. The MRI signal in these areas drops off more slowly, i.e. there is more MRI signal coming from these brain areas. Hence BOLD fMRI is more sensitive to blood flow-related supply of oxygen to this area than to oxygen consumption in the active area. In other words, BOLD fMRI is sensitive to differences in blood flow into the active area.
What type of interpretation is used for fMRI?
Reverse inference.
inference to ‘psychological processes’ from ‘patterns of activation’ revealed by functional magnetic resonance or other scanning techniques.
if changes in activation in a given brain area are specifically associated with a psychological process, then changes in activation in that area point to the involvement (or modulation of) the hypothesised psychological process
What determines whether reverse inference (fMRI) is
(a) whether a pattern of brain activity is found reliably for the hypothesised psychological process (sensitivity)
(b) whether a given pattern of brain activity is also associated with other psychological processes (specificity) – indeed if a brain area is activated by multiple kinds of psychological process, then its activation cannot be taken as evidence of the involvement of a specific psychological process
Researchers who make reverse inferences need to provide detailed information on both sensitivity and specificity
What are the weaknesses of fMRI?
comes a lot from large blood vessels like veins and less from smaller blood vessels like capillaries. But larger blood vessels are further away from the active tissue.
Also blood flow changes associated neuronal activity are slow, hence temporal resolution is low.
The scanner is very noisy- harder to use auditory stimuli and to record vocal responses. In order to do it, one needs to pause the scanning for a few seconds while the auditory stimulus is presented or while the participant is making a vocal response (“sparse imaging”)
What is PET?
Used before fMRI. But moderately invasive, as radioactivity is introduced into body. Measures indirect metabolic correlates of neural activity.
What is EEG?
the change in voltage (electricity) recorded from sensors on the scalp. EEG frequencies can tell us about the state of the brain (i.e.) sleep. Segment of the EEg associated with particular stimuli can be analysed separately: Event- Related Potentials (ERPs).
Different types of stimuli are separately averaged and then compared.
What are the strengths of EEG?
very high temporal resolution: it can provide detailed temporal information about the processing of a stimulus
Compared to fMRI it is relatively cheap and accessible
What are the weaknesses of EEG?
limited spatial resolution (it cannot localise activity in the brain with precision or confidence), due to the complexity of the inverse problem
What is the problem with fMRI and EEG overall?
For a given set of fMRI activations or modulations of ERP components, it is difficult to be certain which (if any) are NECESSARY for a given task/psychological process. The fact that the fMRI activations (or ERP component modulation) co-occur with an experimental condition does not mean that they cause it, or that they are essential for the process to take place…
Why is TMS better than fMRI and EEG?
Lesions the brain so its more causal
How does TMS work?
Large current briefly discharged into a coil of wire held on the subject’s head. •current generates a rapidly changing (increasing) magnetic field around the coil of wire and this field passes into the brain. In the cortex, the magnetic field generates electric (ionic) current through neurons’ membranes.
Depending on the intensity and number of stimulation pulses, TMS can increase or reduce excitability (the ease with which neuronal activity is produced by an action or a stimulus)
In the context of goal-directed behaviour (e.g. cognitive task), this tends to result in disorganisation of neural activity, typically resulting in impaired performance
Thus, the effect is similar to that of neurological lesion, only mild, reversible and safe
What are the strengths of TMS?
The effects of a singleTMS pulse on behaviour can be brief, therefore temporal resolution with respect to target behaviour (and underlying brain activity) is relatively high.
•TMS can answer the critical question of causality (which cannot be answered using brain measurement methods like fMRI or EEG): is a brain area or structure necessary for performance
How does eye-tracking work?
monitors pupil position by emitting an infrared beam and detecting its reflection from the cornea- the reflection is weaker where the pupil is. The sampling rate can be as high as 1000 Hz, allowing not only measures of fixations (their timing location) but also precise measures of saccades (path and velocity)
What are the primary measures in eye-tracking?
Fixation: when the gaze stops on some visual attribute. The attributes of a fixation are: spatial location (where?), onset latency (when did it start?), and duration (how long?)
Saccade: the eye-movement. Its attributes are: amplitude (how far?), onset (when did its execution start?), velocity (how fast?), shape (linear or somewhat curved?)
Pupil diameter: it is correlated with arousal and the emotional state, e.g. the perception of emotional signals usually increases pupil size
What are the strengths of eye-tracking?
•It has very high spatial and temporal resolution
What are the weaknesses of eye-tracking?
- One challenge in eye-tracking is that attention is allocated before the gaze moves to the location of the attentional spotlight – and it is quite difficult to estimate that lag – estimates range from ~80 to 200 ms
- Another challenge is that people can shift spatial attention without moving their eyes – especially if the visual objects are relatively close in space – and this can complicate inferences about the location of the attention “spotlight” in the absence of gaze shifts
What are the three problems in assessing the socio-emotional problems in children?
Rapid developmental transitions. - Many behaviours that are clinically relevant in older children may be normal in younger children. For example, temper tantrums in toddlers may reflect their emerging sense of self but may cause parent’s concern in older children.
Lack of data intergration from a bunch of difference sources.
Who provides information about the child? Parents, teachers, friends, themselves, observers. Depends on the topic being looked at.
What method of assessment have they employed? Questionnaires, interviews, behavioural/ cognition assessments (writing, vocab)
What timeframe have they used? Depends. (i.e.) anxiety would need to be measured for 6 months as the DSM-5 says this is the criteria.
Difficulty determining level of impairment/functioning.
Aspects of child functioning: Adaptation to situational demands, Development of new skills, Relationships (i.e., interactions with peers), Physical health.
Regarding observations of parent-child interactions, describe the probelm with the presence of the observer.
issues with reactivity. Can fix this by discarding first 10 of interaction as it is suggested the reactivity is more prevalent in the beginning
Regarding observations of parent-child interactions, whats up with the type of task
Type of task (structured vs. unstructured. Unstructured there are no targets, they are more likely to be relaxed and display more positive behaviour. Structured may elicit more anxiety
Whats the strength of observations?
Researchers define and choose target behaviours. Can look at microscopic processes and mechanisms. Have data on rates and frequencies.
What is the weaknesses of observations?
expensive, time consuming and require extensive training.
In questionnaires, what are some factors that affect childrens accurate responding?
Age
Response formats- faces they can choose from could be good, like smiley, neutral and sad faces.
Phrasing or complexity of questions
Factual information versus abstract concepts.