Psoriatic Arthritis Flashcards

1
Q

Tretinoin

A

(Tretin-X; Retin-A)
Topical: Retinoid (Topical vitamin A analog)

*increase cell turnover
*decrease cell cohesiveness
*Sensitivity to sun exposure, wind, cold
ADRs: skin irritation; redness; peeling

Pregnancy category C

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2
Q

Adapalene

A

(Differin)
Topical: Retinoid

3rd generation retinoid
Less peeling/ dryness and skin discoloration than tretinoin

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3
Q

Tazarotene

A

(Avage; Tazorac)
Topical: Retinoid
Prodrug and synthetic acetylenic retinoid —> tazarotenic acid

Alters gene expression
ADRs: redness; itching; stinging; burning

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4
Q

Ustekinumab

A

(Stelara) - 12 week SC dosing
MOA: IL-12/23 inhibitor — > reduced T-cell activation

ADEs: Infections, ISR, HA, fatigue.
*Rare: Reversible posterior leukoencephalopathy syndrome (RPLS) -> (headache, confusion, seizures); pustular psoriasis

Monitoring: Injection site reactions; Latent TB- TB testing prior to initiation ; Infections; Malignancy; Worsening psoriasis (pustular)

Moderate to severe plaque psoriasis
Psoriatic arthritis

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5
Q

Secukinumab

A

(Cosentyx) - 4 week SC dosing
IL-17 inhibitor

ADEs: Infections (nasopharyngitis, upper respiratory tract infection, mucocutaneous candida); neutropenia; exacerbations of Crohn disease?; uticaria; diarrhea

Monitoring: Injection site reactions; Latent TB- TB testing prior to initiation ; Infections

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6
Q

Apremilast (Otezla)

A

(Otezla) - titrate to 30mg BID dosing ORAL
PDE-4 inhibitor (targeted)

ADEs: N/D, HA, weight loss; DEPRESSION

Monitoring: Scr; weight; GI effects ; depression ; CYP3A4 metabolism; CrCl

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