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Derm Pharm 2 > Psoriasis and Acne > Flashcards

Psoriasis and Acne Flashcards

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Dermatology Board Prep flashcards
1
Q

MOA of adalimumab

A

IgG1 binds TNF-alpha

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2
Q

MOA of etanercept

A

p75 TNF receptor and Fc IgG1 binds ups TNF-alpha

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3
Q

MOA of inflixmab

A

variable region of mouse monoclonal antibody on human IgG1 binds up TNF-alpha

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4
Q

Adverse effects of inflixmab

A

heart failure, murine protein HSR

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5
Q

adverse effect of etanerecept

A

sepsis

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6
Q

black box warnings of infliximab, etanercept, and adalimumab

A

infection including fungal/myco-bacterial/viral; neoplasia; TB

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7
Q

MOA of ustekinumab

A

binds to p40 subunit to IL12 and IL23 and disrupts the over-expressed signal transduction, suppresses pro-inflammatory TH1 and Th17 cells

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8
Q

adverse effects of ustekinumab

A

anaphylactic rxns, pts at increased risk of infections and neoplasia

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9
Q

CIs for ustekinumab

A

live virus vaccination and test for latent TB before initial treatment

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10
Q

what are the effects of retinoids

A

inhibits keratinization, alterations of cellular cohesiveness, tumor prevention/therapy, induction of apoptosis, immunologic and anti-inflammatory effects

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11
Q

functions of vitamin A

A

embryonic growth, morphogenesis, differentiation/maintenace of epithelial tissues, reproduction, visual function

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12
Q

RAR?

A

targets cellular differentiation and proliferation

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13
Q

RXR?

A

induces apoptosis

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14
Q

systemic toxicities of retinoids

A
  1. similar to Vit A intoxication
  2. hyperlipidemia
  3. teratogens
  4. depression/suicidal
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15
Q

RAR leads to what adverse effects

A

mucocutaneous and musculoskeletal symptoms

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16
Q

RXR leads to what adverse effects

A

physiochemical changes

17
Q

adverse effects of topical retinoids

A

erythema, desquamation, burning, and stinging. increases photosensitivity

18
Q

MOA calcipotriene

A

binds to Vit D receptor, complexes w/ RXR-alpha and binds DNA vit D response elements

19
Q

adverse effects of calcipotriene

A

hypercalcemia and hypercalciuria w/ extreme doses, increases photosensitivity

20
Q

what is more potent than calcipotriene

A

calcitriol (hormonally active form of vitamin D3)

21
Q

MOA of benzoly peroxide

A

pro-drug converted to benzoic acid, free radial liberator kills P. acnes

22
Q

adverse effect of benzoly peroxide

A

drying of skin, marked peeling, erythema

23
Q

why is it often combined w/ antibacterials?

A

to prevent development of antimicrobial resistance

24
Q

notes for treating acne w/ antimicrobials

A

resistance may arise so change treatment if no response in 4-8 weeks, combo therapy, simply regiment as much as possible

25
Q

MOA of corticosteroids

A

anti-inflammatory, anti-pruritic, vasoconstrictive. increases production of lipocortins and decreases formation and release of endogenous inflammatory mediators

26
Q

What are the following corticosteroids classified as: hydrocortison, betamethasone valerate, flucinonide, clobetasol propionate

A

Hydro - mild
Beta - moderate
Fluo - potent
Clob - very potent

27
Q

what are adverse effects of flourinated steroids?

A

rosacea like skin rash around mouth so DONT apply to face!

28
Q

topical adverse effects of steroids

A

iatrogenic Cushing’s syndrome, dermal atrophy, corticoid rosacea, perioral dermatitis, steroid acne, hypopigmentation, hypertrichosis

29
Q

MOA of salicylic acid

A

topical keratolytic, causes desquamation of horny layer of skin

30
Q

adverse effect of salicylic acid

A

prolonged use in pts w/ renal/hepatic impariment - salicylism; neonatal toxicity via breast milk and contact toxicity from drug applied to chest area

31
Q

Mild and severe features of salicylate intoxication

A

Mild: dizziness, tinnitus, N/V, tachycardia
Sever: lethagy, hallucinations, seizures, renal and liver failure, edema

32
Q

MOA of acitretin

A

second gen retinoid.
inhibits keratinization, alterations of cellular cohesiveness, tumor prevention/therapy, induction of apoptosis, immunologic and anti-inflammatory effects

33
Q

MOA of adapalene?

A

first gen retinoid.
inhibits keratinization, alterations of cellular cohesiveness, tumor prevention/therapy, induction of apoptosis, immunologic and anti-inflammatory effects

34
Q

MOA of tazarotene?

A

third gen retinoid.
inhibits keratinization, alterations of cellular cohesiveness, tumor prevention/therapy, induction of apoptosis, immunologic and anti-inflammatory effects

Derm Pharm 2 (10 decks)

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