Psoriasis Flashcards
Psoriasis histology generally
Acanthodians with elongated rete ridges, hypogranulosis, hyper and para-keratosis, dilated blood vessels, lymphocytic perivascular infiltrate, and neutrophil aggregates in the epidermis (Monroe microabscesses)
Psoriatic arthritis presentation
Asymmetric oligoarthritis of small joints of hands and feet
Psoriasis and HLA-Cw6
An allele associated with earlier onset of psoriasis
Which cytokine correlates with psoriasis severity
IL 22
What do Th17 cells induce release of?
IL 17 and IL 22
Which transcription factor which is activated by a variety of cytokines May link keratinocytes activation and immune cells
STAT3
What are some systemic triggering factors for psoriasis
Local injury (lag time to lesions is 2-6 weeks)
Infections, particularly strep
HIV
Hypocalcemia
Psychogenic Dyess
Medications: lithium, IFNs, beta blockers, and antimalarials
Etoh smoking and obesity
Non-pustular types of psoriasis
Chronic plaque psoriasis
Guttate (usually in kids preceded by strep)
Erythrodermic
Pustular types of psoriasis
Generalized pustular
Pustulosis of the palms and soles
Acrodermatitis continua of Hallopeau
Variants of generalized pustular psorasis
Impetigo herepetiformis
Von zumbusch: associated with fever and acute onset and dissipation of pustules
Angular pattern: pustules at advancing edge
Exanthematic type: usually following infection or medications like lithium
Localized pattern
Term for thick adherent scale oh hair shafts in scalp psoriasis
Pityriasis amiantacea
Psoriasiform lesions with thick yellow scale and often pustules in Reiters syndrome
Keratoderma blennorrhagicum
Psoriatic plaques on penis
Balanitis circinata
Inflammatory linear verrucous epidermal nevus
Linear psoriasiform lesions that follow the lines of Blashko
Sneddon-Wilkinson disease
Very superficial (aka subcorneal without spongiform) pustules
