Psoriasis Flashcards
1
Q
Name the types of psoriatic arthritis
A
- Asymmetric oligoarthritis or polyarthritis (most common)
- Arthritis mutilans (least common)
- Symmetric polyarthritis (RA-like)
- Spondylitis (axial)
- Distal interphalangeal joint (DIP) disease
- Enthesopathy (inflammation of ligaments and tendons at insertion point on bones)
2
Q
Name the therapies for psoriatic arthritis
A
- NSAIDS
- Sulfasalazine
- MTX
- Etanercept
- Ustekinumab
3
Q
Reiter’s Syndrome (similar to psoriasis with psoriatic arthritis)
- Name 3 clinical features
- Name the associated genotype
A
- Urethritis, conjunctivitis, arthritis
- HLA-B27
4
Q
Reiter’s Syndrome (similar to psoriasis with psoriatic arthritis)
- Etiology
A
- Chlamydia trachomatis involving infection of GU tract
5
Q
Reiter’s Syndrome (similar to psoriasis with psoriatic arthritis)
- Clinical features
A
- Multiple small, yellow vesicles that break, become confluent, and form superficial erosions, frequently on genitals and palms
- Crusted, hyperkeratotic papules and plaques on plantar surfaces -> keratoderma blennorrhagicum
- Perimeatal balanitis
- Oral mucosa with shallow erosions, stomatitis
- Thick and brittle nails, heavy subungual hyperkeratotic deposits
6
Q
SAPHO syndrome
A
- Synovitis
- Acne (fulminans or conglobata)
- Pustulosis (pustular psoriasis)
- Hyperostosis
- Osteomyelitis
7
Q
Sneddon-Wilkinson Disease
- Clinical features
A
- Subcorneal pustular dermatosis
- Middle-aged women
- Superficial pustules in annular and serpiginous patterns
- Abdomen, axillae, groin
- Sterile pustules
8
Q
Sneddon-Wilkinson Disease
- Histology
- Treatment
- Association
A
- Pustules below stratum corneum without acantholysis, many neutrophils
- Dapsone, acitretin, nbUVB
- IgA monoclonal gammopathy
9
Q
Nonurethral form of Reiters
A
- Shigella flexneri (most common), Salmonella, Yersinia, Ureaplasma urealyticum, Borrelia burgdorferi, Cryptosporidia Campylobacter fetus
