PSA final revision

Question 1

nitrofurantoin

Answer 1

avoid if eGFR<45
eGFR 30-44 short course for uncomplicated LUT infection with multi-drug resistance
pulmonary disease as sfx

Question 2

Citalopram

Answer 2

Hyponatraemia
Increased bleeding with dabigatran
omeprazole increases exposure
Serotonin syndrome

Question 3

ACEi and Cr

Answer 3

Cr rise of <20% expected

Question 4

COPD exarcebation

Answer 4

Ipatropium bromide 500 mcg/ salbutamol 2.5mg/2.5ml nebs

Question 5

Renal impairment

Answer 5

hold allopurinol>aspirin

Question 6

Statin

Answer 6

> 40% in non-HDL

Question 7

Common confusion causing drugs

Answer 7

Opioids, bentos, trazadone

Question 8

Beta blockers

Answer 8

CI in PVD, ACEi cautioned

Question 9

Methotrexate monitoring

Answer 9

LFTS, UES, FBC (liver toxicity, pulmonary fibrosis)

Question 10

Simvastatin + gemofemobrizil

Answer 10

risk of myopathy

Question 11

Macrolides

Answer 11

TDP

Question 12

Ondansetron

Answer 12

avoid if QTc prolonged

Question 13

ciclosporin

Answer 13

Hyperkalaemia and renal- every 2 weeks for 3 months then monthly

Question 14

naproxen

Answer 14

ankle oedema

Question 15

GLP1 analogue (sema/liraglutide)

Answer 15

vomiting sfx

Question 16

oxycodone

Answer 16

good for renal impairment as metabolised by liver

Question 17

fentanyl

Answer 17

not for acute pain

Question 18

tramadol

Answer 18

can reduce the seizure threshold
SSRIs- serotonin syndrome

Question 19

Insulin

Answer 19

oedema
0.1units/kg/hr

Question 20

NSAIDs

Answer 20

avoid in HTN- fluid retention
CI in asthma
CI in VZV- necrotising fasciitis

Question 21

gingival hyperplasia

Answer 21

ciclosporin + nifedipine (CCBs), phenytoin, mycophenylate

Question 22

digoxin

Answer 22

dig + cholecalciferol–> dig toxicity (ECG + dig level)
rate control in AF for sedentary pt

Question 23

aspirin and sulfasalazine

Answer 23

cross sensitivity

Question 24

LMWH

Answer 24

CI in thrombocytopenia

Question 25

doxy + isotretonoin

Answer 25

Benign intracranial hypertension so CI

Question 26

GCA

Answer 26

Methylpred sodium succinate 1g injection IV for 3 days

Question 27

Tremor

Answer 27

haloperidol + antipsychotics
salbutamol
theophylline

Question 28

Gout causing drugs

Answer 28

aspirin, ticagrelol, diuretics, calcineurin, ciclospoirin, pyrazinamide, tacrolimus

Question 29

sulfonyurea (gliclazide)

Answer 29

wt gain