PSA Flashcards
ADR
ACEi
Cough
Hyperkalaemia
Avoid in bilateral renal damage
ACEi monitoring
Serum potassium
Risk of hyperkalaemia
ADR
Amlodipine
Oedema
AR
Amiodarone
Pulmonary fibrosis
Thyroid dysfunction
ADR
Carbamazepine
Hyponatraemia
ADR Clozapine
Agranulocytosis
ADR
Gliclazide
Hypoglycaemia
ADR
Metformin
Lactic acidosis
ADR statins
Myalgia (pain in muscles)
Bisphosphonates
Common + serious SE
Monitoring req
Common SE - constipation, diarrhorea, dizzy, dysphagia, fever, headache, flu lik sx
Rare - Atypical fmur fracture
Steven Johnson syndrome
Monitor - calcium + mineral metab (Vit D def) pre tx; monitor serum calcium conc during tx
Methotrexate
Common + Serious SE
Monitor req
Common
Anaemia, diarrhoea, GI sx, skin reaction, throat ulcer
Necrotising demyelinating leukoencephalopathy
Neurotoxicity
Give folic acid to reduce side effects
Monitor:
FBC, U+E, LFTs 1-2 weekl until established,2-3m post
Report signs infection, sore throat
Tx folinic acid in acute toxicity
Insulin
Common + serious SE
Monitor req
ommon -oedema
OD - hypo
Serious - refraction disorder
Monitor blood glucose conc
- between 4 - 9 mol/L
4-7 mmol/ L pre meals
<9mmol/L post meal
Statin
Common + Serious SE
Monitor req
Common - asthenia, constipation, dizzy, flatulente, myalgia, nausea, sleep problems, diarrhorea
Rare - myopathy, peripheral neuropathy
Monitor - Lipid profile FTs Creatnine kinase HbA1C
Drugs to avoid in asthma
NSAIDs
Beta blockers
Adenosine - verapamil may be used as alternative
Pregnancy drugs to avoid
Antibiotics tetracyclines aminoglycosides sulphonamides and trimethoprim quinolones: the BNF advises to avoid due to arthropathy in some animal studies
Other drugs ACE inhibitors, angiotensin II receptor antagonists statins warfarin sulfonylureas retinoids (including topical) cytotoxic agents
