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Year 6 > PSA > Flashcards

PSA Flashcards

1
Q

ACEi ADR

A

Hyperkalaemia

Dry Cough

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2
Q

ACEi DDI

A

NSAIDs - renal damage

K+ sparing diuretics - hyperkalaemia

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3
Q

Beta blockers ADR

A

Bronchospasm

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4
Q

Beta blockers DDI

A

Rate-limiting CCBs (verapimil, diltiazem) - severe hypotension and heart failure

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5
Q

Carbamazepine MOA and use

A

Voltage gated sodium channel blocker

Anticonvulsant

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6
Q

Carbamazepine ADR

A

Skin reaction

Steven Johnson’s in HLA-B*1502 allele in chinese/thai

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7
Q

Carbamazepine DDI

A

Inducer of CYP450 enzymes

REDUCED efficacy of warfarin, CCBs, ABx

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8
Q

Diuretics ADR

A

Hypokalaemia

Hyponatraemia - THIAZIDES

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9
Q

Diuretics DDI

A

K+ sparing + ACEi - hyperkalaemia

Diuretics + ACEi - hypotension

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10
Q

Erythromycin ADR

A

N+V

Diarrhoea

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11
Q

Erythromycin DDI

A

CYP450 inhibitor

Macrolides ENHANCE efficacy warfarin, CCBs, ABx

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12
Q

Erythromycin drug class

A

Macrolide

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13
Q

Fluoroquinolones (-floxacins) ADR

A

Hypersensitivity

Tendon Damage

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14
Q

Fluoroquinolones (-floxacins) DDI

A

NSAIDs- induce convulsions

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15
Q

Grapefruit juice DDI

A

CYP450 inhibitor

Increases SIMVASTATIN plasma concn

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16
Q

MAO inhibitor ADR

A

Cheese reaction

17
Q

MAO inhibitor DDI

A

Other antidepressants - TCAs = dangerous
Carbamazepine/SSRIs -> serotonin syndrome
Opioids - serotonin syndrome, hypertensive crisis

18
Q

NSAIDs ADR

A

GI bleeding

Hyperkalaemia

19
Q

NSAIDs DDI

A

ACEi - AKI
Quinolones - induced convulsions
Warfarin - increased bleeding risk
SSRI - increased bleeding risk (GI + brain)

20
Q

Opioids ADR

A

Respiratory depression
Constipation
Addiction

21
Q

Opioids DDI

A

MAOi - serotonin syndrome, hypertensive crisis

TCAs - increased sedation

Year 6 (9 decks)

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