PSA

Question 1

ACEi ADR

Answer 1

Hyperkalaemia

Dry Cough

Question 2

ACEi DDI

Answer 2

NSAIDs - renal damage

K+ sparing diuretics - hyperkalaemia

Question 3

Beta blockers ADR

Answer 3

Bronchospasm

Question 4

Beta blockers DDI

Answer 4

Rate-limiting CCBs (verapimil, diltiazem) - severe hypotension and heart failure

Question 5

Carbamazepine MOA and use

Answer 5

Voltage gated sodium channel blocker

Anticonvulsant

Question 6

Carbamazepine ADR

Answer 6

Skin reaction

Steven Johnson’s in HLA-B*1502 allele in chinese/thai

Question 7

Carbamazepine DDI

Answer 7

Inducer of CYP450 enzymes

REDUCED efficacy of warfarin, CCBs, ABx

Question 8

Diuretics ADR

Answer 8

Hypokalaemia

Hyponatraemia - THIAZIDES

Question 9

Diuretics DDI

Answer 9

K+ sparing + ACEi - hyperkalaemia

Diuretics + ACEi - hypotension

Question 10

Erythromycin ADR

Answer 10

N+V

Diarrhoea

Question 11

Erythromycin DDI

Answer 11

CYP450 inhibitor

Macrolides ENHANCE efficacy warfarin, CCBs, ABx

Question 12

Erythromycin drug class

Answer 12

Macrolide

Question 13

Fluoroquinolones (-floxacins) ADR

Answer 13

Hypersensitivity

Tendon Damage

Question 14

Fluoroquinolones (-floxacins) DDI

Answer 14

NSAIDs- induce convulsions

Question 15

Grapefruit juice DDI

Answer 15

CYP450 inhibitor

Increases SIMVASTATIN plasma concn

Question 16

MAO inhibitor ADR

Answer 16

Cheese reaction

Question 17

MAO inhibitor DDI

Answer 17

Other antidepressants - TCAs = dangerous
Carbamazepine/SSRIs -> serotonin syndrome
Opioids - serotonin syndrome, hypertensive crisis

Question 18

NSAIDs ADR

Answer 18

GI bleeding

Hyperkalaemia

Question 19

NSAIDs DDI

Answer 19

ACEi - AKI
Quinolones - induced convulsions
Warfarin - increased bleeding risk
SSRI - increased bleeding risk (GI + brain)

Question 20

Opioids ADR

Answer 20

Respiratory depression
Constipation
Addiction

Question 21

Opioids DDI

Answer 21

MAOi - serotonin syndrome, hypertensive crisis

TCAs - increased sedation