PSA Flashcards
What percentage of potassium correlates with 20mmols?
0.15%
What percentage of potassium correlates with 40mmol?
0.3%
How much hydrocortisone is 5mg prednisolone equivalent to?
20mg
How much dexamethasone is 5mg prednisolone equivalent to?
750micrograms
Name some stimulant laxatives?
Senna
Bisacodyl
Rectal glycerol suppository
When is bisacodyl contraindicated?
Bowel obstruction
Acute abdominal conditions
Acute IBD
Severe dehydration
Name some osmotic laxatives?
Lactulose
Macrogol
How does macrogol work?
Draws water in from large bowel
When is macrogol not recommended?
If patient already bloated - SE is bloating
What kind of laxative is docusate?
Softener & stimulant
Name some bulk forming laxatives?
Ispaghula husk
Methylcellulose
Sterculia
When are bulk forming laxatives indicated?
Adults with small hard stools if fibre cannot be increased in the diet.
What symptoms may be exacerbated with BFL?
Symptoms of flatulence, bloating, and cramping
How long do BFL take to work?
72hrs
How do you treat patients with opioid induced constipation?
An osmotic laxative (or docusate sodium to soften the stools) and a stimulant laxative is recommended.
What should be avoided in opioid induced constipation?
Bulk-forming laxatives
What does co- codamol contain?
Paracetamol and codeine
Post- op pain ladder?
- Reg paracetamol
- Reg codeine/ dihydrocodeine
- Reg/ PRN morphine sulphate (modified release)
4.. Reg/ PRN morphine sulphate (immediate release)
When is fluid resuscitation used?
When haemodynamically unstable
When is replacement used?
Losses e.g. N&V, DKA
When is maintenance used?
Nil by mouth
How much water /kg per day in maintenance ?
25-30ml/kg/day
How much Na+/K+/Cl- /kg per day in maintenance ?
1mmol/ kg
How much glucose per day in maintenance ?
50-100g/ day
How many grams of glucose is in 1000ml 5% dextrose?
50g
What is the maximum rate for potassium?
DO NOT prescribe >10mmol per hour
What is the risk when using large volumes of 0.9% saline?
Inc risk of hyperchloraemic metabolic acidosis
When should 5% glucose be avoided and why?
Patients who have had a stroke
Inc risk of cerebral oedema
What should not be given with ibuprofen?
Steroids
Minimum & maximum doses of bisoprolol?
Minimum = 1.25mg
Maximum = 20mg
Minimum & maximum doses of atorvastatin?
Minimum = 10mg
Maximum = 80mg
Starting dose of metformin?
500mg
Drugs to consider in delirium/ acute confusion?
Zopiclone
Analgesics
Anticholinergics
Antidepressants
Antipsychotics
Metoclopramide
Electrolyte imbalance e.g. low Na+
Which drugs can cause dehydration?
Diuretics
When should metformin be withheld in renal impairment?
EGFR <30ml/ minute/ 1.73
Name some CYP450 inhibitors
Omeprazole
Amiodarone
SSRI’s
Grapefruit juice
Cimetidine
Macrolides
CYP450 inducers?
Carbamezapine
Barbituates
Phenytoin
Rifampicin
Pioglitazone
Steroids
Rifampicin
What do CYP450 inducers do?
Inducers increase the expression level of CYP450 enzymes resulting in increased metabolism of drugs and subsequently reducing the therapeutic concentration.
What do CYP450 inhibitors do?
Inhibitors prevent the CYP450 enzymes from working or reduce the rate of an enzyme-catalysed reaction. Consequently, this decreases drug metabolism in the body and increases the potential for toxicity.
When is metaclopramide contraindicated?
Bowel obstruction
be causious in delirium
Micrograms to milligrams?
Divide by 1000
Fluids in children?
100ml/kg for first 10kg
50ml/kg for next 10kg
20ml/kg for weight over 20kg
How often is methotrexate taken?
Once a week
Methotrexate + NSAIDS –> ?
Low platelet count
Trimethoprim + methotrexate –>?
Bone marrow suppression
PPIs + methotrexate –> ?
Inc levels of methotrexate
What can a SE of furosemide be?
If given fast –> can cause deafness
Common drugs related to ototoxicity?
Gentamicin
Bumetanide
Furosemide
Vancomycin
When is furosemide more likely to be ototoxic?
IV administration
If patient has renal impairment
4 C’s for C. diff?
Clindamycin
Co- amoxiclav
Ciprofloxacin
Cephalosporins (ceftriaxone, cefalexin)
Clarithromycin + simvastatin –> ?
increases the exposure to Simvastatin
Common symptoms of opioid toxicity?
Pinpoint pupils
Coma
Respiratory depression
Antidote for opioid toxicity?
Naloxone
When are pupils constricted?
Heroin
Morphine
Oxycodone
Methadone
Codeine
Hydrocodone
When are pupils dilated?
Amphetamines
Methamphetamines
Cocaine/ crack
Hallucinogens
Speed
Phenytoin + oral contraceptives?
Potent CYP enzyme inducer and increases breakdown of oral contraceptives
Treatment for drug induced extrapyramidal symptoms?
Procyclidine
Serotonin syndrome?
Abrupt
Rapidly resolving
Myoclonus and tremor
Inc reflexes
Mydriasis
Neuroleptic malignant syndrome?
Gradual
Prolonged
Diffuse rigidity
Dec reflexes
Hyperthermia
What is NMS a SE of?
Antipsychotics
Info on benzodiazepines?
Can affect driving/ operating machinery –> DVLA
Extrapyramidal symptoms?
E.g. tremor, involuntary muscle contractions
Atypical antipsychotics?
Quietapine, olanzapine
SE of atypical antipsychotics?
Weight gain
Diabetes
Rise in serum lipids
Examples of typical antipsychotics?
Chlorpromazine, haloperidol
SE’s of typical antipsychotics?
Acute dystonia
Akathisia
Restlessness
Tardive dyskinesia
Is ankle swelling related to dose of amlodipine?
No (don’t tend to change dose)
What is the risk of the quinolone ciprofloxacin?
Tendon rupture (achilles, elbow)
What increases the risk of tendon rupture if on ciprofloxacin?
On steroids
What is a SE of quinolone?
Prolong QT duration !!!
Reduce seizure thresholds
Drugs to be stopped in AKI?
NSAIDs
Aminoglycosides
ACEI
ARB
Diuretics
Function of calcium gluconate in hyperkalaemia?
Stabalisation of cardiac membrane
Function of insulin dextrose/ salbutamol in hyperkalaemia?
Short-term shift in potassium from extracellular to intracellular fluid compartment
Function of calcium resonium in hyperkalaemia?
Removal of potassium from body
When does IM not work?
If cachetic
Function of/ examples of SGLT2 inhibitors?
E.g. dapagliflozin
Inhibits sodium- glucose co transporter in proximal tubule of nephron –> glucose secretion
What to be way of with SGLT2i?
Euglycaemic DKA’s
UTI’s
Normalising CO2 on ABG?
BAD SIGN - can no longer breath out CO2
Which medications may exacerbate heart failure?
TZD - pioglitazone
Verapamil - neg inotropic effect
NSAIDS
Glucocorticoids
Flecainide
Antibiotics CI in pregnancy?
Tetracyclines
Aminoglycosides
Sulphonamides and trimethoprim
Quinolones
Drugs CI in pregnancy?
ACEI, ARB
Statins
Warfarin
Sulphonylurea’s
Retinoids
Cytotoxic agents
Weight per volume - 20%?
20 grams per 100mls
Weight per volume - 1%?
1 gram per 100mls
Weight per weight?
1% w/w = 1g in 100grams
What medications to stop for surgery?
ACEI
ARBs
Diuretics
Anticoagulants + antiplatelets
HRT and COCP
Lithium
NSAIDs
How long before surgery should COCP be stopped?
4 weeks before
Diabetic meds in surgery - which ones to stop/ alter?
Metformin - if OD/BD - continue, if TDS - stop lunchtime dose
SGLT-2i - omit on day of surgery
Sulphonylureas - omit morning dose
TZD/ DPP4i GLP-1 in surgery?
Take as normal
What can St John’s wart syndrome contribute to?
Serotonin syndrome
Cytochrome p450 inducers pneumonic?
SCRAP GP
Sulphonylureas
Carbamezapine
Rifampicin
Alcohol
Phenytoin
Griseofulvin
Phenobarbitone
CYP450 inhibitors pneumonic?
SICK FACES
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol & grapefruit juice
Chloramphenicol
Erythromycin
Sulfonamides
If NBM can patients take oral drugs?
No, must be IV
Metformin important information?
Look for signs of lactic acidosis e.g. dyspnoea, muscle cramps, abdominal pain, hypothermia, asthenia
Important info - sulphonylurea?
Signs of hypoglycaemia
Higher risk in elderly or renal impairment
SGLT2 inhibitors important info?
Signs of DKA, even if BM normal
Important side effect to inform patient on - prednisolone?
Adrenal suppression
Nitrates important info?
Can develop rapid tolerance
Tamoxifen important info?
VTE risk - seek immediate medical attention if SOB
SE’s of bisphosphonates?
Atypical femoral fractures
Osteonecrosis of the jaw
Important info for all antipsychotics?
Photosensitisation
Drowsiness
Effects of alcohol enhanced
Lithium important info?
Report signs of toxicity
Hypothyroidism
Renal dysfunction
Benign ICH - headache, visual disturbance
Maintain fluids
Avoid dietary changes (which inc or dec sodium intake)
Avoid NSAIDs
Clozapine important info?
Risk of agranulocytosis
Sodium valproate important info?
Appropriate contraception
Exclude pregnancy
What to look up if contraceptives & breast cancer?
Sex hormones
Does combined HRT inc or dec risk of breast cancer?
Increases
Effect of antidepressants on sodium?
Hyponatraemia (consider if drowsy, confused, convulsions)
When should lithium levels be taken after dose?
12 hours
Lithium monitoring?
measure levels 1 week after starting treatment, 1 week after every dose change ad then weekly until level stabilises
Lithium monitoring when stable?
measure every 3 months for first year then 6 months thereafter
Initial SE of lithium?
Diho, vertigo, weakness, dazed
Long term SE of lithium?
Hypo/ hyperthyroidism, hyperparathyroidism, nephrotoxicity, renal tumours
Once established - lithium monitoring?
Weight, U&E’s, TFTs, Ca every 6 months
When is levonorgestrel effective?
within 72hrs UPSI
When is ulipristal acetate effective?
Within 120 hours UPSI
Which hormonal emergency contraceptive is most effective?
Ulipristal acetate
Hormonal emergency contraception if BMI >26 or weight >70kg?
Ulipristal acetate
or
Double dose levonorgestrel
Treatment of VTE in pregnancy?
Dalteparin
HRT if LMP <1yr ago?
cyclical combined
HRT if LMP >1 yr ago?
Continuous combined
If hysterectomy for endometriosis, do they need combined or oestrogen only HRT?
Need combined
When should antiviral Tx be considered in shingles?
Immunocompromised
Non- truncal involvement (neck, legs, perineum)
Moderate to severe pain or rash
>50 - to reduce post herpetic neuralgia
If antivirals commenced for shingles - when?
Within 72hrs of rash
Trigeminal neuralgia treatment?
Acute - carbamazepine
When is digoxin toxicity worsened?
Hyperkalaemia
When should digoxin levels be taken?
6 hrs after dose
What monitoring is required for digoxin?
U&E’s
What should be added to bloods if K+ low?
Magnesium
What can an adverse effect of carbimazole be?
Pancreatitis
Neutropenia
Agranulocytosis
Drugs that cause agranulocytosis?
Clozapine
Phenytoin
Carbimazole
What is trough concentration?
Pre- dose
If trough gentamicin dose is high…?
Interval between doses should be increased
What is peak concentration?
Post- dose
If peak gentamicin dose high…?
Dose must be decreased
What should be measured when using thiopurines
TPMT levels
SE’s of amiodarone?
Hepatotoxicity
Thyroid (hyper/ hypo)
Corneal microdeposits
Pulmonary toxicity
Important info for methotrexate?
Often stopped if acutely unwell
Counsel to report signs of blood disorders
Rate of sodium inc in 24 hrs for hyponatraemia?
No more than 10mmol/L in 24 hrs
If on PPI and hyponatraemic what should you do?
Switch to famotidine
SVT arrhythmia management?
Vagal manouvres
IV adenosine (6-> 12 -> 18mg)
Electrical cardioversion
When is adenosine contraindicated?
Asthma
COPD
decompensated heart failure
Long QT
what medications are taken at night?
Statins
Amitriptylline
how much should levothyroxine be inc in pregnancy?
25-50mcg
If INR ≥1.5 before surgery on warfarin?
Phytomenadione (vit K1)
Who is at inc risk of bit D deficiency?
Asian women
Drugs which dec serum potassium?
Thiazide diuretics
Loop diuretics
Acetazolamide
Drugs which inc serum potassium?
ACEi
Angiotensin- 2 receptor blockers
Spironolactone
Potassium supplements
Potassium sparing diuretics
SIADH
Hyponatraemia
Euvolemic
Mechanism of action - digoxin?
Dec conduction through AVN which slows ventricular rate in af and atrial flutter
Inc force of cardiac muscle contraction
Stimulates vagus nerve
When should digoxin level be measured in suspected toxicity?
within 8-12 hrs of last dose
Symptoms of digoxin toxicity?
Generally unwell
Lethargy
Nausea, vomiting
Confusion
Yellow/ green vision
Arrhythmia
Gynaecomastia
What tends to precipitate digoxin toxicity?
Hypokalaemia
Normal lithium range?
0.4-1.0mmol/L
Ciclosporin drug monitoring?
Trough levels just before dose
Phenytoin level monitoring?
Not routinely
Trough levels immediately before dose if concerned
Codeine equivalence of 10mg oral morphine sulphate?
100mg
Nephrotoxicity due to contrast media?
25% inc in creatinine occurring within 3 days of IV administration of contrast media
2-5days after
How to prevent contrast nephrotoxicity?
IV 0.9% sodium chloride at rate of 1ml/kg/hour for 12 hours pre and post procedure
Withold metformin
O2 management if risk factors for hypercapnia?
Prior to ABG’s –> 28% venturi mask at 4l/min
Causes of hyperkalaemia?
AKI
Drugs
Metabolic acidosis
Addison’s disease
Rhabdomyolysis
Massive blood transfusion
Glucocorticoid meds effect on glucose?
Can cause hyperglycaemia
Assisted alcohol withdrawal?
Long- acting benzodiazepine e.g. chlordiazepoxide hydrochloride
Common adverse effect of beta blockers?
Erectile dysfunction
What drug can induce cholestatic jaundice?
Flucloxacillin
Citalopram + dabigatran?
Inc risk of bleeding
ACEi effect on creatinine?
Small rise in creatinine (<20%) is to be expected when starting an ACEi & does not require investigation or change to prescription
What should be measured when beta blocker used for af?
Heart rate
Adverse effects of ciclosporin?
Nephrotoxicity
Hypertension
Aim for statin?
After 3 months – a >40% reduction in non- HDL cholesterol
When is ondansetron contraindicated?
QT prolongation
IV fluid resuscitation?
Use crystalloids that contain sodium with bolus of 500mls over <15mins
Glucose not required
if experience GI SE’s with metformin?
Offer modified release
Max dose of citalopram in elderly?
20mg daily
Drugs which can cause diarrhoea?
Alendronic acid
Lansoprazole
Drugs that cause ankle oedema?
Amlodipine
Naproxen
First line therapy for c. diff?
Oral vanc
Life threatening c. diff?
Oral Vanc and IV met
Common SE of liraglutide (GLP-1)?
N&V
What is prolonged corticosteroid use associated with?
Insomnia
When is fentanyl a good option?
Patients with chronic kidney disease
When is gradual withdrawal of systemic steroids indicated?
received more than 40mg prednisolone daily for more than one week
received more than 3 weeks treatment
recently received repeated courses
Effect of carbamazepine on sodium?
Hyponatraemia
Is warfarin safe in breastfeeding?
Yes
Primary prevention atorvastatin dose?
20mg daily
Secondary prevention atorvastatin dose?
80mg daily
Drugs that should be used with caution in established ischaemic heart disease?
NSAIDS
Oestrogens
Varenicline
Effect of P450 inducers on INR?
Decrease
Effect of P450 inhibitors on INR?
Increase
Verapamil + beta blocker –>?
Contraindicated
Cause life threatening bradycardia
Common adverse effects from amlodipine?
Ankle swelling
Headache
First line for C. diff?
Vancomycin 125mg QDS
How to measure glucose control in DM?
HbA1c
Home glucose readings
Which drugs can reduce hypoglycaemic awareness?
Beta blockers
Usual dose for Ibuprofen?
200-400mg tds
Usual dose for codeine?
30-60mg qds
Usual dose for metoclopramide?
10mg tds
Usual dose for cyclizine?
50mg tds
Usual dose for amoxicillin?
500mg tds
Usual dose for paracetamol?
1g qds
Usual dose for clarithromycin?
500mg bd
Usual dose for Lansoprazole?
15-30mg
Usual dose for omeprazole?
20-40mg
Usual dose for clopidogrel?
75-300mg od
Usual dose for aspirin?
75-300mg od
Usual dose for simvastatin:?
10-80mg on
Usual dose for atenolol?
25-100mg od
Usual dose for ramipril?
1.25-10mg od
Usual dose for bendroflumethiazide?
2.5mg od
Usual dose for furosemide?
20 mg od - 80mg bd
Usual dose for amlodipine?
5-10mg od
Usual dose for levothyroxine?
25-200mcg od
Usual dose for metformin?
500mg od - 1g bd
Dose for breakthrough pain?
1/6 of total morphine dose
Which medications are usually take at night?
Statins
Amitriptyline
How long is tamoxifen taken for breast cancer?
5 years
Important info about tamoxifen?
VTE
Hot flushes
Medications that can be used for smoking cessation?
Varenicline
Bupropion hydrochloride
E.g. of ICS and LABA inhalers?
Formoterol with budesonide
Formoterol with beclometasone
Salmeterol with fluticasone
When is pioglitazone contraindicated?
Hx of bladder cancer
Hx of heart failure
DKA
Treatment for mild acute migraine?
Aspirin/ NSAID/ triptan?
Treatment for moderate to severe acute migraine?
Triptan and anti- emetic
Volume of glucose 10% infusion?
150-200ml
Volume of glucose 20% infusion?
75-100ml
Fluids containing sufficient sodium chloride without excessive potassium chloride?
Sodium chloride 0.9%
Hartmann’s solution
Ringer’s solution
Plasmalyte
Common side effect of tacrolimus?
Tremor
SE’s of empagliflozin (SGLT2 inhibitor)?
Hypovolaemia
Thirst
UTI’s
Urosepsis
Why can hypovolaemia contribute to postural hypotension?
Reduced blood volume is insufficient to maintain stable BP during position changes esp against force of gravity when standing
Effect of amitriptyline on QT interval?
Prolonged
Common SE of dexamethasone if taken at night?
Insomnia
When should nitrofurantoin be avoided?
eGFR <45
What bacteria is cefalexin effective agains?
Many gram + e.g. staph aureus and strep
Some gram - e.g. E.coli
Primary treatment for hypercalcaemia?
Rehydration with sodium chloride 0.9%
Early signs of agranulocytosis?
mouth ulcers
sore throat
fever
infective symptoms
What happens if calcium and iron taken at same time?
Dec absorption of iron
How should rivaroxaban be taken?
With food!
Indicators of onset of hepatic necrosis?
RUQ tenderness
Hepatomegaly
What can co- amoxiclav be assoc. with?
Adverse hepatic events e.g. cholestasis, jaundice, elevated ALP/ GGT/ ?bilirubin
Trimethoprim + methotrexate –>?
Folate deficiency which manifests as bone marrow suppression
Can statin be continued if transaminases are raised?
Yes, if less than 3x the upper limit of normal
When is eplerenone contraindicated?
Ongoing hyperkalaemia
What to monitor if on mineralocorticoid therapy?
U&E’s
Methylphenidate monitoring?
BP
Pulse
Appetite
Height
Weight
Psych disorders?
Isotretinoin monitoring?
Serum lipids
LFT’s
LMWH monitoring?
Platelet counts
Sulfasalazine monitoring?
FBC
First line treatment for open angle glaucoma?
Latanoprost
Resus fluids?
0.9% sodium chloride
Hartmann’s
Plasma- Lyte
When is ulipristal acetate contraindicated?
Asthma
Ibuprofen + ramipril–>?
Inc risk of nephrotoxicity and hyperkalaemia
Pain relief for mild/ mod cholecystitis?
Paracetamol
Anti- inflammatory drugs
Pain relief for severe cholecystitis pain?
IM diclofenac
Features of essential tremor?
Symmetrical
High frequency
Suppressed with concentration
Improves with alcohol
Ferrous fumarate dose?
210mg
Naloxone dose?
400mcg IV
Treatment for fungal nail infection?
Terbinafine
First line anti- emetic in Parkinson’s disease?
Domperidone
Wart treatment?
Salicyclic acid
Symptoms to monitor if on labetalol?
Itching (has been associated with severe hepatocellular damage).
Sedation if has Parkinson’s?
Lorazepam 1mg IV stat (avoid haloperidol)
SE of folic acid?
FARTING x
dose of adrenaline if used in croup?
400 micrograms/kg (max 5mg).