PSA Flashcards
Antibiotics that should be avoided in breastfeeding
Ciprofloxacin
Tetracycline
Chloramphenicol
Sulphonamides
Psych drugs that should be avoided in breastfeeding
Lithium
Benzodiazepines
MoA of amiodarone
Blocks potassium channels
- inhibits depolarisation and hence prolongs the action potential
Limiting factors of amiodarone
Half life of 20-100 days (loading doses often used)
Should be given into central veins (causes thrombophlebitis)
Has proarrhythmic effects
P450 inhibitor so decreases metabolism of warfarin
Adverse effects of amiodarone
Thyroid dysfunction : hypo and hyper
Corneal deposits
Pulmonary fibrosis
Liver fibrosis
Peripheral neuropathy
Photosensitivity
Slate grey appearance
Thrombophlebitis
Bradycardia
Why is metformin contraindicated in recent MI
Because metformin can cause lactic acidosis if taken during a period where there is tissue hypoxia eg recent MI, sepsis, AKI, severe dehydration
MoA of bendroflumethiazide
Inhibits sodium reabsorption by blocking the Na+-Cl symporter at the beginning of the DCT
Drugs that can cause intracranial hypertension
Lithium
Isotretinoin
Corticosteroids
Moa of LMWH
Activates antithrombin III
Forms a complex that inhibits factor Xa
Why should ACEi be held when patients are unwell
Hold if infection / poor oral fluid intake to reduce chance of AKI
Why should ACEi be held when patients are unwell
Hold if infection / poor oral fluid intake to reduce chance of AKI
What is expected shortly after starting an ACEi
A small rise in creatinine (<20%)
Doesnt require investigation or a change in prescription
What are the main roles of beta blockers in AF treatment
Rate control
Measure heart rate 3 days after starting
Counselling advice for loperamide
Should be taken after each loose stool
Treatment of antipsychotic induced Parkinsonism
Procyclidine hydrochloride
Treatment when bleeding (on warfarin) and in shock
Dried prothrombin complex
