PSA

Question 1

What kind of drug is Ondansetron?

Answer 1

5-HT3 receptor antagonist

e.g. ondansetron 4mg IV

Question 2

What drugs prolong the QT interval?

Answer 2

A2B1C1D2E1
Anti-arryhthmics (amiodarone, sotalol, flecainide)
Anti-anginals
Anti-biotics (fluroquinolones, macrolides, aminoglycosides)
Anti-depressants (SSRIs, TCAs)
Diuretics
Anti-emetics (Ondansetron)

Question 3

What kind of drug is cyclizine?

Answer 3

histamine H1 receptor antagonist

e.g. cyclizine 50mg IV

Question 4

What kind of drug is metoclopramide?

Answer 4

prokinectic anti-emetic

e.g. metoclopramide 10mg IV

Question 5

What common drugs prescribed in MICROGRAMS instead of MILIGRAMS

Answer 5

Levothyroxine
Digoxin
Naloxone
Atropine
Folic acid
Fludrocortisone

Question 6

What are ASF associated with benzodiazepines?

Answer 6

Increase the falls risk (elderly), decreased alertness, confusion and drowsiness and hypotension

Question 7

What is important to remind patients of when taking a macrolide antibiotic (clarithromycin)

Answer 7

stop taking statin as interaction can casue rhabdomyolysis (dark urine, myalgia)

clarithromycin: CYP3A4 inhibitor which increases concentration of statins in the blood resulting in rhabdomyolysis

Question 8

What is IV paracetmol dose for patients weighing more thn 50kg?

Answer 8

1g IV paracetamol every 4-6 hours with dose administered over 15 minutes

max dose is 4g per day

Question 9

What are contraindications for NSAIDs?

Answer 9

peptic ulcer disease/gastro bleeding
vitamin K antagonist/direct thrombin inhibitor/anti-platelet (risk of major bleed)
gout
decreased renal function (eGFR less than 50mL/minute/1.73m2)