providing info Flashcards
CI of metformin
CKD
recent MI, sepsis
iodine containing xray media
side effects tamoxifen
menstrual disturbance: vaginal bleeding, amenorrhoea
hot flushes - 3% of patients stop taking tamoxifen due to climacteric side-effects
venous thromboembolism
endometrial cancer
UFheparin:
MOA, SE, monitoring, admin
- activates antithrombin III to inhibit Xa, IXa, Xia and XIIa
- SE: bleeding, HIT, osteoP
- monitor APTT
- IV
LMWH
MOA, SE, monitoring, admin
-activates antibrombin III to inhibit Xa
- SE: bleeding -> lower risk of HIT and osteoP
- monitor with Xa
- subcut
SE of ciclosporin
everything is increased
- BP
- fluid retention
- potassium
- hair
- gums
- glucose
- tremor
hepatic and nephrotoxic
CYP450 inducers and effects
CRAP GPS
Carbemazepines
Rifampicin
alcohol -> chronic
Phenytoin
Griseofulvin
Phenobarbitone
Sulphonylurea/Smoking/St john
increases metabolism of drug so reduces its therapeutic conc
CYP450 inhibitors
ASICKFACES.COM
Acute alcohol intake
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol & Grapefruit juice
Chloramphenicol
Erythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
reduced metabolism of drug so increases the risk for potential toxicity
quinilones SE
lower seizure threshold
tendon damage
lengthen QT
amiloride moa
blocks enac in DCT
type of potassium sparing drug
SE sildenafil
blue vision -> blue pill
non arteritic AIN
nasal congestion
flushing
GI SE
headache
priapism
sildenafil CI
taking nitrate containing drugs
hypoT
recent stroke or MI -> wait 6 months
drugs that worsen urinary retention
- TCA antidep
- Antihistamines
- Antipsychotics
- Opioids
- NSAID
Disopyramide
drugs that cause imparied glucose tolerance
- thiazides, furosemide (less common)
- steroids
- tacrolimus, ciclosporin
- interferon-alpha
- nicotinic acid
*Antipsychotics atypical
harmful drugs in pregnancy
- Tetracyclines
- Aminoglycosides
- Sulphonamides
- Trimethoprim
- Quinilones
- ACEI
- Statins
- Warfarin
- Sulfonylureas
- Retinoids
- Cytotoxic agents
- Valproate etc
drugs that worsen seizure control
- Alcohol or cocaine
- Ciprofloxacin
- Aminophylline -> lowers seizure threshold
- Bupropion
- Methylphenidate
Mefenamic acid
drugs that exacerbate HF
- Thiazolidinediones
- Verapamil
- NSAIDS
- Glucocorticoids
Flecanide
drugs that exacerbate psorasis
- Beta blockers
- Lithium
- Antimalarials
- NSAID
- ACEI
- Infliximab
drugs used in caution in asthma pt
nsaid
beta
adenosine
drugs causing lung fibrosis
- amiodarone
- cytotoxic agents: busulphan, bleomycin
- anti-rheumatoid drugs: methotrexate, sulfasalazine
- nitrofurantoin
- ergot-derived dopamine receptor agonists (bromocriptine, cabergoline, pergolide)
