Protozoa pt 5 Flashcards
Sarcocystis neurona common name
(EPM) Equine protozoal myeloencephalitis
Sarcocystis neurona Definitive host
opossum
Sarcocystis neurona Intermediate host
-cat, striped skunk, armadillo, fishers, raccoons, etc
Sarcocystis neurona aberrant host
-horse
Sarcocystis neurona ppp
7-14 days
Sarcocystis neurona pp
1 week to several months
Sarcocystis neurona after ingestion and matures into______ int the ______ take _______
- sarcocyst
- muscle
- 2-3 months
Sarcocystis neurona normal life cycle
- Gametogony in final host
- Schizogony in termediate host leads to bradyzoites in muscle tissue
Sarcocystis neurona accidental life cycle
-Schizonnts develop into horse’s neurons, not in muscle cells
Sarcocystis neurona pathogenesis and lesions: final host
-Final host non path
Sarcocystis neurona pathogenesis and lesions: intermediate host
-intermediate host pathogenic effect due to 2nd schizogony in vascular endothelium
Sarcocystis neurona pathogenesis and lesions: accidental host
-pathogenic due to 3rd schizogony in nervous tissue rather than muscle
Sarcocystis neurona clinical signs: horses
- progressively debilitating disease affecting cns, brain, brainstem, and spinal cord
- unusual lameness or seizures
- difficulty with standing/walking
- may progress very rapidly
what is important about EMP in the united states
-the most commonly diagnosed infectious equine neurologic disease
EPM diagnosis: antemortem
- clinical signs
- western blotting, 14, 13 and 3 kDa
- PCR-CSF
EPM diagnosis: postmortem
-histopathological demonstration of S. neurona in CNS