Prototype Drugs Exam 2 Flashcards
Clomiphene Citrate - drug class
ovulation stimulant
Clomiphene Citrate - MOA
stimulates release of follicle-stimulating hormone (FSH) and luteinizing (LH)
Clomiphene Citrate - use
stimulate ovarian follicle growth
Clomiphene Citrate - contra
pregnancy, undiagnosed vaginal bleeding, depression, fibroids, hepatic dysfunction, thrombophlebitis, primary pituitary or ovarian failure
Clomiphene Citrate - side effects
breast discomfort, dizziness, fatigue, depression, anxiety, weakness, increased appetite, nausea, abdominal bloating or pain, heavier menes, flushing, dermatitis, headache, photophobia, diplopia, decreased visual acuity
Conjugated Estrogen - drug class
estrogen replacement in menopause
Conjugated Estrogen - MOA
-develops and maintains female genital system, breasts, secondary sex characteristics
-increase protein synthesis
Conjugated Estrogen - use
-moderate to severe vasomotor symptoms of menopause
-vaginal dryness and atrophy
Conjugated Estrogen - admin
PO
-give continuously with no interruptions
Conjugated Estrogen - interactions
-INcreased effects with corticosteroids
-DEcreased effects with rifampin, anticonvulsants, barbituates
-decreasES effect of anticoagulants and hypoglycemics
Conjugated Estrogen - contra
undiagnosed vaginal bleeding, pregnancy, lactation, severe, liver disease, venous thrombosis, personal history of breast cancer
Conjugated Estrogen - caution
cardiovascular disease, severe renal disease, DM
Conjugated Estrogen - black box warning
absolute contra in MI, new primary malignancy, stroke, thromboembolism, dementia
Conjugated Estrogen - side effects
nausea, vomiting, fluid retention, breast tenderness, leg cramps, breakthrough bleeding, chloasma
Conjugated Estrogen - adverse
jaundice, thromboembolic disorders, depression, hypercalcemia, gallbladder disease
