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Cancer > Protooncogen > Flashcards

Protooncogen Flashcards

1
Q

Oncogen

A

Genes cuyos productos ayudan a la proliferacion celular

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2
Q

Gen supresor de tumor

A

Gen cuyos productos ayudan a inhibir la proliferacion celular

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3
Q

Proto-oncogenes

A

codifican proteinas que influyen en el ciclo celular ya sea favoreciendo su progresion a procesos de proliferacion celular o induciendo a muerte celular por medio de apopotosis

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4
Q

Modo de activacion Protooncogen HST-1

A

Sobreexpresion

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5
Q

Tumores asosiados a HST-1

A

Cancer de mama, melanoma, Osteosarcoma, Cancer de estomago, cancer de vejiga,

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6
Q

Modo activacion proto-oncogen FGF3

A

Amplificacion

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7
Q

Tumores asociados FGF3

A

Cancer de mama, Melanoma, osteosarcoma, cancer de estomago, cancer de vejiga

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8
Q

Modo de activacion protooncogen ERBB1 (EGFR)

A

Mutacion

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9
Q

Tumores asociados a ERBB1 (EGFR)

A

Adenocarcinoma de pulmon

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10
Q

Modo de activacion Proto-oncogen RET

A

Mutacion puntual

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11
Q

Tumores asociados a RET

A

Carcinomas tiroideos

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12
Q

Protooncogen HGF

A

Sobreexpresion . Cancer tiroides

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13
Q

Protooncogen Kit

A

Mutacion puntual. Cancer Gastrointestinal

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14
Q

Modo activacion Protooncogen ALK

A

Translocacion, Mutacion puntual, Formacion de gen de fusion

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15
Q

Tumores asociados ALK

A

Adenocarcinoma de pulmon , neuroblastoma

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16
Q

Modo de activacion Gen RAS (KRAS, HRAS, NRAS)

A

Mutuacion puntual

17
Q

Tumores asociados a RAS

A

Cancer de tiroides
(NRAS a melanoma)
(Kras a Cancer de pulmon celulas pequeñas y no pequeñas)

18
Q

Metodo de activacion Braf

A

Mutacion y traslocaciones

19
Q

Tumores asociados a Braf

A

Melanomas, tumor de tiroides

20
Q

Secuencias particulares portadas por un virus capaz de producir tumores

A

V (antes del gen)
ejemplo: V-MYC

21
Q

Reorganizacion cromosomica ejemplo

A

Cromosoma Philadelphia t(8:14)

22
Q

Gen supresor de tumores : RB

A

Por mutacion ya sea hereditaria o esporadica se pierde la funcion del gen RB normal que tenemos y se produce un tumor (retinoblastoma)

23
Q

P53: Gen supresor de tumores

A

Proteina reguladora de la transcripcion

24
Q

Alteraciones de P53

A

Puede producir mutaciones puntuales que causas carcinomas
Sindrome de li frumeni

25
Q

Genes asociados a cancer

A

Melanoma: HST-1, FGF3, NRAS, BRAF
Tiroides: RET, RAS (los 3), HGF, BRAF
Pulmonar: EGFR, ALK, KRAS

Cancer (1 decks)

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