proton pump inhibitors

Question 1

indication of PPIs?

Answer 1

peptic ulcers, dyspepsia and GORD.

Question 2

MOA of PPIs?

Answer 2

work by supressing gastric acid secretion by inhibiting the hyrogen-potassium adenosine triphosphate (proton pump) enzyme syste, on the apical membrane of the gastric parietal cells. The block of the final production of HCL decreases stomach acid levels.

Question 3

contraindication of PPI’s?

Answer 3

known allergy to drug

Question 4

names of PPI’s?

Answer 4

“prazoles”: esomeprazole, lansoprazole. omeprazole, rabeprazole

Question 5

side effects of PPI’s?

Answer 5

abdominal pain; constipation; diarrhoea; flatulence, GI disturbances; headaches; N&V.

Question 6

what are the monitoring requirements of PPIs?

Answer 6

measurement of serum-magnesium concentrations should be considered before prolonged treatment with a PPI, specifically when used alongside drugs that can cause hypomagensaemia/ with digoxin.

Question 7

patient/ carer advice?

Answer 7

P/c advice= counselling on adminstraion of oradispersible