Proteins Flashcards

1
Q

Which form are all amino acids in ?

A

L optical isomer

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2
Q

Hydrophobic

A
Glycine 
Alanine
Proline
Valine
Leucine
Isoleucine 
Tryptophan 
Phenylalanine
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3
Q

Hydrophilic

A
Serine 
Theory one
Tyrosine
Asparagine
Glutamine
Cysteine
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4
Q

Positively charged side chain

A

Arginine
Lysine
Histidine is protonated (+) under pH 6

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5
Q

Negatively charged

A

Glutamate

Aspartate

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6
Q

Why can proteins not tolerate a great change in pH?

A

Ionisation state of amino acids is essential for function.
Changes in pH = change in ionisation state = change in property
Amino acids can take up and release protons = gives them capacity to resist some changes in pH

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7
Q

When do disulphide bridges form?

A

Cytosine chains oxidise

Covalent bond between 2 amino acids

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8
Q

Why does proline cause a kink in the peptide chain?

A

When proline is added = loss of NH group
Side chain can’t form hydrogen bonds with C=O of another part of chain
KINK

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9
Q

What is a parallel beta strand?

A

Beta sheets run parallel to each other

Beta sheets run anti parallel = antiparallel beta sheet

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10
Q

How does warfarin work?

A

Glutamate needs to be converted to gamma-carboxylglutamate
This is needed for calcium binding
Warfarin inhibits this reaction

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