Protein trafficking and Vesicle secretion

Question 1

What is Munc18?

Answer 1

central in membrane fusion and essential for vesicle fusion whereas individual SNAREs are not.

Question 2

What causes Ohtahara syndrome?

Answer 2

mutations in Munc18

heterozygous de novo

Question 3

What is synaptotagmin 1?

Answer 3

Synaptotagmin-1 is a synaptic vesicle Ca2+-binding protein

Synaptotagmin-1 is essential for fast Ca2+-triggered release

Synaptotagmin-1 uses complexin as essential co-activator

Ca2+-binding to Synaptotagmin-1 triggers fast release

Question 4

two types of synaptotagmins?

Answer 4

8 bind calcium

8 dont