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AntiBx-PSI-(Tetracyclines and Glyco) > protein synthesis Tet's and Tigra > Flashcards

protein synthesis Tet's and Tigra Flashcards

1
Q

What are the Teracyclines

A

Doxycycline
Minocycline
Tetracycline

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2
Q

What is the Glycylcycline

A

Tigecycline

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3
Q

Which bind 30S

A

Aminogycosides
Tetracyclines
Glycylcyclines

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4
Q

Which inhibit 50S

A 
Chloramphenicol
Clindamycin
Macrolides
Linezolid
Streptogramins
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5
Q

Most common treatment of severe acne and rosacea

A

Tetracyclines

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6
Q

Don’t take with milk/antacids

A

Tetracyclines

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7
Q

Teratogenic

A

Tetracyclines (D)
Tigecycline
Aminoglycosides (D)

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8
Q

Discoloration and hyperplasia of teeth

A

Tetracyclins

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9
Q

Main AE is photosensitivity

A

Tetracyclins

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10
Q

Last resort for MDR b/c increased risk of mortality

A

Tigecycline

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11
Q

DOC empiric Tx infective endocarditis

A

Gentamycin with Vanco or PCN

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12
Q

What can you give to syphilis patients allergic to PCN

A

Tetracyclins

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13
Q

DOC Tetracyclins

A 
Chlamydia,
 M. pneumoniae
Lyme disease w/o CNS, joints
Rickettsia
Cholera, 
Anthrax prophylaxis
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14
Q

Where is Tetracycline used as a combination therapy

A 
H. pylori
Malaria prophylaxis
Plague, 
Tularemia, 
Brucellosis
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15
Q

Lipid soluble, IV for STIs and prostatitis

A

Doxycyclin

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16
Q

Reduce meningococcal carrier state

A

Minocycline

17
Q

Where are Tetracyclines excreted

A 
Urine
Except Doxycycline (bile)
18
Q

Where to Tetracyclines concentrate

A

Kidney
Spleen
Skin
Liver

19
Q

Stunting of growth

A

Tetracyclines

20
Q

Other Tetracycline AE

A

Photosensitivity
Renal dysfunction
Hepatotoxicity
Dizziness/Vertigo

21
Q

Mechanisms of Tetracycline Resistance

A

Increase efflux,
decrease influx
Interfering with ribosome binding
Enzymatic inactivation

22
Q

Military personnel taking Drug X for malaria prophylaxis and develops photosensitivity

A

Doxycyxline

23
Q

What can expired Tetracycines cause

A

Fanconi’s Syndrome

Defective reabsorption in PCT

24
Q

Broad spectrum use against MDR

A

Tigecycline

25
Q

Given for complicated skin, soft-tissue and intra-abdominal infections

A

Tigecycline

26
Q

DOC Hepatic encephalopathy

A

Lactulose

27
Q

Tigecycline elimination

A

Bile/Fecal

28
Q

Susceptible to Proteus and Pseudomonas efflux pumps

A

Tigecycline

AntiBx-PSI-(Tetracyclines and Glyco) (1 decks)

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