protein synthesis Tet's and Tigra Flashcards
What are the Teracyclines
Doxycycline
Minocycline
Tetracycline
What is the Glycylcycline
Tigecycline
Which bind 30S
Aminogycosides
Tetracyclines
Glycylcyclines
Which inhibit 50S
Chloramphenicol Clindamycin Macrolides Linezolid Streptogramins
Most common treatment of severe acne and rosacea
Tetracyclines
Don’t take with milk/antacids
Tetracyclines
Teratogenic
Tetracyclines (D)
Tigecycline
Aminoglycosides (D)
Discoloration and hyperplasia of teeth
Tetracyclins
Main AE is photosensitivity
Tetracyclins
Last resort for MDR b/c increased risk of mortality
Tigecycline
DOC empiric Tx infective endocarditis
Gentamycin with Vanco or PCN
What can you give to syphilis patients allergic to PCN
Tetracyclins
DOC Tetracyclins
Chlamydia, M. pneumoniae Lyme disease w/o CNS, joints Rickettsia Cholera, Anthrax prophylaxis
Where is Tetracycline used as a combination therapy
H. pylori Malaria prophylaxis Plague, Tularemia, Brucellosis
Lipid soluble, IV for STIs and prostatitis
Doxycyclin
Reduce meningococcal carrier state
Minocycline
Where are Tetracyclines excreted
Urine Except Doxycycline (bile)
Where to Tetracyclines concentrate
Kidney
Spleen
Skin
Liver
Stunting of growth
Tetracyclines
Other Tetracycline AE
Photosensitivity
Renal dysfunction
Hepatotoxicity
Dizziness/Vertigo
Mechanisms of Tetracycline Resistance
Increase efflux,
decrease influx
Interfering with ribosome binding
Enzymatic inactivation
Military personnel taking Drug X for malaria prophylaxis and develops photosensitivity
Doxycyxline
What can expired Tetracycines cause
Fanconi’s Syndrome
Defective reabsorption in PCT
Broad spectrum use against MDR
Tigecycline
Given for complicated skin, soft-tissue and intra-abdominal infections
Tigecycline
DOC Hepatic encephalopathy
Lactulose
Tigecycline elimination
Bile/Fecal
Susceptible to Proteus and Pseudomonas efflux pumps
Tigecycline
