PROTEIN SYNTHESIS INHIBITORS (TETRACYCLINES, AMINOGLYCOSIDES, MACROLIDES, CLINDAMYCIN, LINEZOLID)

Question 1

Name the classes of antibiotics under protein synthesis inhibitors

Answer 1

30s Tetracyclines, Aminoglycosides
50s Macrolides, clindamycin, linezolid

Question 2

Name at least 2 classes of antibiotics which are 30S protein synthesis inhibitors and their respective antibiotics

Answer 2

Tetracyclines (tetracycline, doxycycline, minocycline)
aminoglycosides (gentamicin, amikacin
Glycylcycline (tigecycline)

Question 3

What do tetracyclines cover?

Answer 3

Doxycycline: MSSA, h.influenzae, atypicals (chlamydial, klebsiella, mycoplasma), anaerobes

Question 4

What do aminoglycosides cover?

Answer 4

Gentamicin, amikacin: gram negative cover: h. influenzae, e.coli, klebsiella, proteus, ESBL-producing, enterobacter, pseudomonas

Question 5

What does tigecycline cover?

Question 6

Name 3 classes of antibiotics which are 50S protein synthesis inhibitors and their respective antibiotics in each class

Answer 6

Macrolides (Azithromycin, Clarithromycin, Erythromycin)
Clindamycin, Linezolid

Question 7

What do macrolides cover?

Answer 7

Azithromycin and clarithromycin: h.influenzae, Anaerobes, atypicals
Erythromycin: Atypicals only

Question 8

What does clindamycin cover?

Answer 8

Anaerobes, and gram positive only: MSSA, streptococcus

Question 9

What does linezolid cover?

Answer 9

Gram positives only.