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Pharmacology Mod 3 > Protein synthesis inhibitors, amnioglycosides, macrolides, tetracyclines > Flashcards

Protein synthesis inhibitors, amnioglycosides, macrolides, tetracyclines Flashcards

1
Q

What are the Aminoglycosides

A

Gentamicin
Amikacin
Tobramycin

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2
Q

what are the Licosamides

A

Clindamycin

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3
Q

What are the Oxazolidinones

A

Linezolid

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4
Q

What are the Macrolides

A

Azithromycin
Clarithromycin
Erythromycin

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5
Q

What are Streptogramins

A

Quinupristin/dafopristin

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6
Q

What are tetracyclines

A

Doxycycline
Minocycline
Tetracycline

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7
Q

What are the protein synthesis inhibitors that inhibit 50S

A

erythromycin (macrolides)
chloramphenical
clindamycin

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8
Q

what are the protein synthesis inhibitors that inhibit 30S

A

tetracyclline
spectinomycin
streptomycin
genamicin, tobramycin (aminoglycoside)
amikacin

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9
Q

What is natures preferred target for antibacterial compounds

A

Ribosomal RNA Target

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10
Q

know slide 7

A
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11
Q

What are aminoglycosides MOA

A
  1. irreversible inhibition on initiation complex through binding of 30S subunit
  2. blocks translocations (movement of ribosome along mRNA)
  3. can cause misreading of mRNA
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12
Q

What ribosomal subunit do aminoglycosides inhibit

A

30S ribosomal subunit inhibited

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13
Q

What type of antibiotics inhibit 30S ribosomal subunits

A

aminoglycosides and tetracyclines

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14
Q

is aminoglycosides bactericidal or bacteriostatis?

A

bactericidal antibiotic

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15
Q

What antibiotic is bactericidal

A

aminoglycosides

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16
Q

Are tetracyclines bacteriostatic or bactericidal?

A

Bacteriostatic antibiotic

17
Q

What is the most common tetracylcine used

A

Doxycycline

18
Q

what are the primary types of tetracyclines

A

tetracycline, doxycycline and minocycline

19
Q

What medication is the alternate choice for MRSA and VRE infections

A

Tetracyclines

Pharmacology Mod 3 (2 decks)

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