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AntiBx-PSI-(Aminoglycosides & Macrolides) > protein synthesis inhibitors Aminoglyco and macrolides > Flashcards

protein synthesis inhibitors Aminoglyco and macrolides Flashcards

1
Q

What are the Aminoglycosides

A 
Gentamycin
Neomycin
Amikacin
Tobramycin
Streptomycin
Netilmicin
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2
Q

What are the Macrolides

A

Erythromycin
Clarithromycin
Azithromycin
Telithromycin

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3
Q

Which bind 30S

A

Aminogycosides
Tetracyclines
Glycylcyclines

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4
Q

Which inhibit 50S

A 
Chloramphenicol
Clindamycin
Macrolides
Linezolid
Streptogramins
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5
Q

DOC plague

A

Streptomycin

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6
Q

Adjunct for hepatic encephalopathy

A

Oral Neomycin

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7
Q

Action of Oral Neomycin in hepatic encephalopathy

A

Reduce NH3 formation by gut bacteria

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8
Q

Only useful against aerobes

A

Aminogycosides

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9
Q

Main Aminoglycoside AE

A

Nephrotoxicity (ATN)

Ototoxicity

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10
Q

Good choice for Pts with PCN allergy

A

Macrolides

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11
Q

Empirit Tx community acuired PNA and pseudomonas

A

Macrolides

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12
Q

DOC pertussis

A

Erythromycin

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13
Q

What is contraindicated to give with MAcrolides

A

Statins

P450 inhibition

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14
Q

Which Macrolide doesn’t inhibit P450

A

Azithromycin

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15
Q

What is the Macrolide effect on the heart

A

QT prolongaion

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16
Q

Irreversible 30S inhibition

A

Aminoglycosides

17
Q

Oral/Topical Aminoglycoside

A

Neomycin

18
Q

Contraindicated in Myasthenia

A

Aminoglycosides (NMJ blockade)

19
Q

Why are Aminoglycosides only good for Aerobes

A

O2 dependent transport into G-

20
Q

Aminoglycoside excretion

A

Renal

21
Q

Aminoglycoside Resistance mechanisms

A

Plasmid to modify/inactivate
Decreased accumulation
Altered/deleted receptor on 30S

22
Q

How does Lactulose cause osmotic diarrhea

A

Acidify gut lumen trapping NH4+

23
Q

Good for URTs

A

Macrolides

24
Q

Bacteriostatic but cidal at high concentrations

A

Macrolides

25
Q

What can Macrolides have cross-reactivity with

A

Clincamycin

Chloramphenicol

26
Q

Can cause hepatotoxicity, MG exacerbation and visual disturbances

A

Telithromycin

27
Q

Macrolide with worst oral absorption and f

A

Erythromycin

28
Q

Macrolide with greatest tissue penetration

A

Azithroycin

Telithromycin

29
Q

Additional Macrolide AE

A 
GI effects (motilin)
Cholestatic hepatitis
30
Q

Macrolide Resistance

A

Decrease influx,
Increase efflux
Esterase hydrolyzes
Methylate binding site

31
Q

What does Clindamycin cross react with

A

Macrolides

AntiBx-PSI-(Aminoglycosides & Macrolides) (1 decks)

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