Protein Synthesis Inhibitors Flashcards
1
Q
Name as many protein synthesis inhibitor categories as you can
A
tetracyclines glycylclines aminoglycosides macrolides chloramphenicol clindaymycin streptogramins linezolid mupirocin
2
Q
Most protein synthesis inhibitors are bacteriostatic or cidal?
A
static
exceptions: aminoglycosides (30s; prevent assembly formation)
..
3
Q
Tetracyclines? Names? MOA?
A
Doxycycline, Minocycline, Tetracycline
Passively enter cell –> concentrated inside of the cell
-very effective against intracellular bacteria
Enter bacteria via transport system unique to bacteria
Reversibly binds to 30s and prevents attachment of aminoacyl tRNA
4
Q
Tetracyclines spectrum?
A
Similar to carbapenems
- gram pos
- gram neg
- aerobic
- anaerobic
- MRSA
