Protein structure and function

Question 1

What do proteins function as?

Answer 1

catalyst
Transporters
motion- myosin filament
antibodies

Question 2

What does an amino acid have?

Answer 2

COOH
NH2
R Group

Question 3

What do proteins exist as ?

Answer 3

optical isomers

- have a chiral carbon

Question 4

What do amino acids exist as ?

Answer 4

Zwitterions

Question 5

What has a positive charge on amino acid

Answer 5

NH3+ when protonated

Question 6

What has a negative charge on amino acid

Answer 6

C00-

Question 7

How many amino acids are there ?

Answer 7

20

Question 8

What are aliphatic side chains?

Answer 8

straight chain carbon= hydrophobic

Question 9

What is Methionine?

Answer 9

AUG

Question 10

What is Methionine side chain?

Answer 10

has thioester, S group and 3 carbons

Question 11

What are aromatic side chain?

Answer 11

ring structure

Question 12

What does OH group mean?

Answer 12

Hydrophillic

Question 13

What is primary structure of proteins?

Answer 13

polypeptide chain- rich in H bonding

Question 14

How is peptide bond formed?

Answer 14

condensation reaction

Question 15

How do linear polypeptide cross link?

Answer 15

disulphide bonds- oxidation of Cys residues

Question 16

What are peptide bonds

Answer 16

3D Rigid/planar - have double bond

Question 17

What does rotation around bond?

Answer 17

Torsion angle

Question 18

What is angle rotation around Nitrogen to C?

Answer 18

Phi

Question 19

What is angle rotation around Carbon to C?

Answer 19

Psi

Question 20

What is secondary structure of PROTEINS?

Answer 20

Folding into alpha and beta sheets

Question 21

How do hydrogen bonds form In the alpha helix?

Answer 21

Nh AND CO group that is 4 residues ahead

Question 22

What is the helix in keratin and collagen have?

Answer 22

Colied-coil proteins

Question 23

What are beta sheets?

Answer 23

2 or more polypeptide chains

Question 24

What Bond stabilises beta sheets

Answer 24

Hydrogen bonds

Question 25

What can beta sheets either be ?

Answer 25

Parallel | antiparallel

Question 26

What are antiparallel sheets?

Answer 26

adjacent NH and CO

Question 27

What are Parallel sheets?

Answer 27

1 amino acid with 2 amino acids on adjacent strand

Question 28

What do beta sheets do?

Answer 28

Hair pin on themselves

Question 29

What is a tertiary protein structure?

Answer 29

3D Structure

Question 30

What do globular protein with tertiary structure have?

Answer 30

Hydrophillic amino acids on outer surface

Question 31

what determines folding of protein in aqueous enviro like the body ?

Answer 31

Hydrophobic residues inside the centre of protein

Question 32

What is Quaternary structure of proteins?

Answer 32

Each polypeptide is a subunit

Question 33

What is Heamoglobin?

Answer 33

4 subunits, 2 alpha subunits and 2 beta

Question 34

What are Self assembling peptides?

Answer 34

monomers in what but self assemble into 3D scaffolds at body pH

Question 35

What is 3D structure of proteins determined by?

Answer 35

amino acid structure