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MGD > Protein Signalling > Flashcards

Protein Signalling Flashcards

0
Q

Location of ER protein signal within polypeptide sequence?

A

N-terminus

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1
Q

Nature of signal for ER proteins?

A

Signal sequence

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2
Q

Are ER proteins folded or unfolded during transfer?

A

Unfolded

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3
Q

Specialist proteins for ER proteins?

A

Signal recognition protein and receptor

Protein translocator

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4
Q

ER signal cleaved or retained?

A

Cleaved by signal peptidase

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5
Q

Does ER protein signalling use energy?

A

Yes - GTP

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6
Q

Nature of nuclear protein signal?

A

Nuclear locanisational signal

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7
Q

Location of nuclear signal within polypeptide sequence?

A

Anywhere on folded surface

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8
Q

Are nuclear proteins folded or unfolded?

A

Folded (fit through pores)

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9
Q

Specialist proteins needed for nuclear proteins?

A

Importin

RanGTP

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10
Q

Nuclear signal cleaved or retained?

A

Retained (for reimporting)

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11
Q

Do nuclear proteins use energy?

A

Yes - GTP

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12
Q

Nature of mitachondria matrix protein signal?

A

Amphipathic

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13
Q

Location of mitochondrial matrix protein signal?

A

N-terminus

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14
Q

Are mitachondria matrix proteins folded or unfolded during transfer?

A

Held by chaperones partially unfolded

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15
Q

Specialist proteins needed for mitachondria matrix proteins?

A

TOM

TIM

16
Q

Signal retained or cleaved for mitochondrial matrix proteins?

A

Cleaved

17
Q

Do mitochondrial matrix proteins use energy?

A

Yes - ATP and electric potential

18
Q

Nature of signal on proteins for lysosomes?

A

Mannose-6-phosphate

19
Q

Location of signal on lysosome proteins?

A

Signal patch

20
Q

Are lysosome proteins folded or unfolded during transfer?

A

Folded

21
Q

Specialist proteins needed for lysosome proteins?

A

Mannose-6-phosphate receptor (trans-Golgi)

22
Q

Do lysosome proteins need energy?

A

Yes - ATP

23
Q

Nature of signal for proteins retained in ER?

A

KDEL (Lys-Asp-Glu-Leu)

24
Q

Location of signal in retained ER proteins

A

C-terminus

25
Q

Are retained ER proteins folded or unfolded during transfer?

A

Folded

26
Q

Specialist proteins needed for retained ER proteins?

A

KDEL receptor (cis-Golgi)

27
Q

Are retained ER protein signals retained?

A

Yes

28
Q

Do retained ER proteins use energy?

A

No

MGD (3 decks)

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