Protein & Lignands Flashcards
Principle 1
Reversible binding of many proteins to other binding materials.
Ligand
A molecule bounds reversible to proteins.
Principle 2
Binding sites are complementary to the lignand in size, shape, and charge, and hydrophobic or hydrophilic character.
Principle 3
Proteins are flexible
Principle 4
Binding of a proteins and a lignand are coupled to a conformational change in proteins, that make bindind sites more complementary to the lignand.
Induce fit
Structural adaptations that occur between protein and ligands.
Principle 5
In a multisubunit protein, conformational change in one subunit can affect the conformation of other subunits.
Principle 6
Interactions between ligands and proteins can be regulated.