Protein Folding

Question 1

A process where a nascent protein becomes native

Answer 1

Protein folding

Question 2

Process by which a protein achieves its native 3d structure

Answer 2

protein folding

Question 3

Protein folding is a ________ ____________ process, which means it’s a non random

Answer 3

Highly regulated

Question 4

Nascent is also known as _______________ protein

Answer 4

Non-functional

Question 5

Native is also known as a ___________ protein

Answer 5

Functional

Question 6

The process of maintaining or the continuous maintenance of protein synthesis and folding

Answer 6

Proteostasis

Question 7

three categories of proteostasis

Answer 7

Protein synthesis
protein folding
degradation

Question 8

part of the cell that synthesize protein

Answer 8

Ribosomes

Question 9

To regulate well the folding process in the proteins there are specialized proteins that assist in protein folding which are called

Answer 9

Chaperones

Question 10

If agregates aren’t managed well it will cause

Answer 10

Disease

Question 11

The more proteins are being produced the greater the rate of

Answer 11

Folding

Question 12

Synthesis of nascent polypeptide would serve as determinant if protein would be _________ or _______

Answer 12

beneficial or toxic

Question 13

information needed for correct protein folding is contained in the

Answer 13

primary structure

Question 14

A peptide bond, which is non rotational, is categorized the amino acid sequence

Answer 14

primary structure

Question 15

Factors that facilitate folding and refolding

Answer 15

Native conformation of a protein is thermodynamically favored

folding is modular

Question 16

Protein folding occurs in an orderly and guided fashion

Question 17

It is modular or step by step

Answer 17

Folding

Question 18

the exterior part of the protein being produced has a __________ residue which means is ______________

Answer 18

polar
hydrophilic

Question 19

Inside a folded polypeptide they have ___ _______ residue which means they are ___________

Answer 19

Non polar
hydrophobic

Question 20

Auxiliary proteins of assist protein folding

Answer 20

Chaperone proteins
protein disulfide isomerase proline cis, trans- isomerase

Question 21

Assistant proteins while proteins are being folded

Answer 21

chaperones

Question 22

Specialized groups of proteins required for proper folding many species of proteins

Answer 22

Chaperones

Question 23

Chaperones also known as

Answer 23

Polypeptide chain binding protein (PCB)

Question 24

hastens to reactions in protein folding

Answer 24

chaperones

Question 25

Chaperones are martir they only provide assist but do not form part of the final structure

Question 26

Chaperones are first identified as

Answer 26

Heat shock protein hsp

Question 27

If there is an increase temperature the chaperones concentration

Answer 27

Increases

Question 28

chaperones act through

Answer 28

Atp mechanism

Question 29

Types of chaperones

Answer 29

Hsp70
chaperonins
hsp60

Question 30

Hsp70 occurs in

Answer 30

Cytoplasm er chloroplast and mitochondria

Question 31

Binds two regions of unfolded polypeptides which in hydrophobic residue and they block folding of proteins that should be remain of folded

Answer 31

Hsp70

Question 32

Hsp70 facilitates quaternary reassemble of

Answer 32

Oligomeric proteins