protein contol of cell division Flashcards
anaphase
phase in which spindle microtubules shortend by depolymerisation sister chromatids are seperated and the chromosomes are pulled to opposite poles
apoptosis
programmed cell deathc triggered by interanal or exteranal signals
caspase cascadee
protease enzymes involed in a series of reactions that destroy a cell
cell cycle
cell increases in size- G1
copies DNA- S stage
preps to divide- G2
and divides my mitosis-Mstage
cell cycle checkpoints
G1,2 and Metaphase checkpoints assesse the rediness of a cell to enter the next stage
centromere
the specialised DNA sequence of a chromosome that links to a pair of sister chromatids
cyclin proteins
proteins that control the progression of cells throughout the cell cycle by activatiing CDK enzymes
CDKS
when activated by cyclin it causes the phosphorylation of protiens
cytokinesis
divison of cytoplams to form two daughther cells
cytoskeleton
supports cells shape and function
death signal molecules
activates caspase
G1 cyclin-CDK
phosphoriylating by G1 cyclin-CDK inhibits the Rb allowing the transcription of the genes that code for proteins needed for DNA replication
interphase
phase of the cell cycle contains G1,2 and S phases
Kinetochores
where microtubles of the spindle attach
metamorphosis
process the involves a significant change in an organisms physical form
metaphase
phase when chromosomes align at the metaphase plate and attach to the spindle fibers
MTOC
structure in eukaryotic cells from which microtubles are produced for the formation of spindle fiberes
microtubles
hollow tubes made up of tubulin
mitosis
division of the nucleus to form two new nuclei
p53
a tumour suppressor protein that can stimulate DNA repair
prophase
a phase where DNA condenses into chromosomes each consisting of two sister chromotids
the nuclear membrane breaks down the spindle forms and chromeosomes attach via their kinetochores
proto-oncogene
a normal gene involved in cell growth or division
Rb
a tumour suppressor protein
spindle fibers
microtubels to which chromomosomes are attached by kinechores