Protein class function

Question 1

HAVe 1 M&M

Answer 1

**Gq: H1, alpha-1, V1, M1 & M3

Receptor –> Gq –> phospholipase C –> (lipids –> PIP2 –>) DAG + IP3

• DAG –> protein kinase C (increased calcium also acts on kinase)
• IP3 –> increase calcium in –> smooth muscle contraction

Question 2

MAD 2s

Answer 2

**Gi: M2, alpha-2, D2

Receptor –> Gi –> adenylyl cyclase –> (ATP –> cAMP –>) protein kinase A –> increased calcium in heart and activate myosin light-chain kinase (smooth muscle)

Question 3

Gs

Answer 3

*Betas 1-3, D1, H2, V2

Receptor –> Gs –> adenylyl cyclase –> same as protein class Gi