Protein Flashcards
amino acids will enter muscle for purpose of _____ ____
protein synthesis
what do some amino acids serve as?
signalling molecules (leucine, branched chain, essential amino acids, etc.) - they turn on molecular switches that stimulate muscle growth
True or False: we have an intracellular concentration of amino acids - at all times they are breaking down and synthesizing and being used to build muscle protein. you can either recylce the proteins (that are breaking down) for the purpose of protein synthesis or they can leave the muscle all together in cases of starvation
true
what happens when you wake up and go to the gym without eating first… (rested fasted state)
rates of protein break down are higher than synthesis becuase you haventconsumed any dietary protein that stimulates synthesis - so you’re slowly losing muscle on a molecular level (protein balance is negative)
what happens to protein when you consume protein?
your body breaks it down into amino acids whcih are then used as substrate to build muscle
what happens with muscle when people are in a weight cutting or long intermitted fasting situation?
the muscle breaks down (rips off its amino acids) and is used to build glucose
how many hours are you in a positve protein balance for after ingesting protein?
about 4 hours
what happens to muscle if you dont do any exercise bewteen the age of 18 and 30?
- you’d maintain the amount of muscle you have because you are in a balanced protein balance so your muscle mass doesnt change
what happens to muscle if you dont do any exercise past the age of 30?
there seems to be a blunting of muscle protein synthesis in human muscle and thats why when people get older, they lose muscle, becausee there is some sort of molecular blunting to the anabolic effects of protein intake
what does fiber to do on protein?
slows down digestion and absoprtion of protein (so if you have say a protein bar with lots of fibre, you can potentially reduce amount of protein that ends up in bloodstream to be used)
how do oyu build muscle?
its only when you combine strength training and adequate intake of protein that you are building muscle (additive effect) - you can’t sit around and eat protein and expect to build muscle and you also can’t train and eat zero protein and expect to grow
what does resistance trainign do on muscles?
resistance exercise, mechanical stimulation of muscle will sensitize your muscle to take up protein
what does exercise not do and do in your muscles?
exercise doesnt itself drive mitochondrial or growth responses. it sensitizes the protein in your muscles to provision of amino acids - so when you take the amino acids in, you’re using them to build the right tissue
amino acid feeding - consume large amount of amino acids at once
rapid rise in synthesis, comes back down within 3-4 hours
slight decrease in breakdown but it doesnt change that much (insulin slows down breakdown a little bit)
what are you building as you train?
when you resisatance train, your building type 1 fibres, mitochondria and in the case of resistance, your building miosyin heavy chains and proteins responsible for increasing muscle size
why do protein synthesis rates come back down?
- protein synthetic machenery is saturdated
- when body tries to use ingested amino acids to build new proteins off RNA, DNA and mRNA, it can do so at a specific rate but overtime, if you go too fast for too long there will be mistakes made (so its a biologically conserve mechanism to stop misfolded and poorly made proteins. also biologically conserve mechanism becuase there has to be a limit to how much muscle someone can have) - this is why we need resistance training to drive this mechanism forward
- (this is why you can’t just sit there and expect to grow muscles even if you eat protein)
types of proteins that are gonna be built with endurance exercise
mitochondrial proteins
types of proteins that are gonna be built with resistance exercise
contractile proteins
essential amino acids
- come from proteins
- your body cannot make them
branched chain amino acids
- come from essential amino acids
- leucine, isoleucine, valine
non-essential amino acids
- come from proteins
- your body can make them
(by liver)
endogenous amino acids
your body creates them
what are the three most potent essential amino acids?
isoleucine, leucine and valine