Prostaglandins and Autacoids

Question 1

corticosteroids MOA, drug names end in

Answer 1

inhibition of phospholipase A, -one

Question 2

NSAIDs inhibit___ and supress______

Answer 2

platelet aggregation, inflammation

Question 3

(indometacin, sulindac)
(meclofenamate, ibuprofen)
(celecoxib, rofecoxib)

Answer 3

COX1 > COX2
COX1 = COX2
COX1 < COX2

Question 4

Asprine MOA

Answer 4

COX1 and COX2

Question 5

drug that can be used for long term treatment of rheumatoid athritis and closure of patent ductus arteriosus

Answer 5

Indomethacin

Question 6

COX2 inhibitors can be used for and have what major side effect

Answer 6

rheumatoid osteoarthritis painful dysmenorrhea, and MI

Question 7

adverse effect of acetaminophen

Answer 7

Hepatotoxicity, Nephrotoxicity and Hypothermia

Question 8

inhibits the lipoxygenase and prevents conversion of AA to lipoxin and LTs and what is it used for

Answer 8

Zileutin, asthma

Question 9

drugs for chronic asthma and MOA

Answer 9

Montelukast and zafirulkast, LT receptor antagonists

Question 10

Dinoprostone, MOA, side effects

Answer 10

PGE2, induction of labor, prolonged vaginal bleeding and menstrual cramps

Question 11

Dysmenorrhea is easily treated with ______

Answer 11

Dysmenorrhea is easily treated with NSAIDs

Question 12

Alprostadil

Answer 12

PGE1, ED treatment, maintain patent ductus arteriosus, administration can cause pain

Question 13

2 drugs to treat pulmonary hypertension

Answer 13

Treprostinil (synthetic PGI2),

Epoprostenol (synthetic PGI2)

Question 14

not as effective at astham treatment since it blocks lipoxygenase and not the LT receptors

Answer 14

Zileuton

Question 15

Latanoprost

Answer 15

PGF2-alpha, treat glaucoma/ocular hypertension, can cause irreversible brown pigmentation

Question 16

3 methods of histamine release with examples

Answer 16

immunologic– IgE/Fc, type I allergic reaction
Mechanical– Na causes release
Drugs- vancomycin, tuborcurine, morphine

Question 17

Effects of histamine on the CNS

Answer 17

increased wakefullness, decreased appetite, circadian rhythms, thirst ADH release

Question 18

Certirizine
Acrivastine
Loratadine
Fexofenadine

Answer 18

2nd Generation Anti Histamines

Question 19

H2 blockers work to control, ends in ___

Answer 19

stomach acid, -dine

Question 20

Buspirone

Answer 20

5HT1A, relieves anxiety without causing sedative, hypnotic and euphoric effects.

Question 21

what to use to treat migraines

Answer 21

triptans

Question 22

effective for treatment of irritable bowel syndrome

Answer 22

Cisapride, serotonin agonist

Question 23

drugs for preventing nausea and vomitting

Answer 23

ondanestron