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Intravenous anesthetics > Propofol flashcards > Flashcards

Propofol flashcards

1
Q

The 4 desired effects of general anesthesia

A

hypnosis, amnesia, analgesia, immobility

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2
Q

The intravenous anesthetic provides all four of the desired effects of general anesthesia without side effects

A

none

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3
Q

Balanced anesthesia

A

Using smaller doses of multiple drugs to provide anesthesia rather than using larger doses of one or two drugs

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4
Q

The most frequently administered anesthetic drug for induction of anesthesia

A

Propofol

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5
Q

Other uses of propofol besides induction of general anesthesia

A

Sedation and to a lesser extent it is used to prevent nausea and vomiting

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6
Q

Propofol chemically is

A

2,6 diisopropylphenol

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7
Q

Propofol is metabolized by

A

70% liver 30% Lungs

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8
Q

Metabolites of Propofol are active or inactive

A

inactive

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9
Q

Metabolites of Propofol are excreted via

A

Kidneys

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10
Q

Wake up from a single dose of Propofol occurs within _____ minutes

A

8-10 minutes

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11
Q

Termination of the effects of Propofol are due to

A

Redistribution of the drug from highly perfused organs (brain) to lesser perfused organs/tissues

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12
Q

Sterile technique is especially important when working with Propofol because

A

the available formulation supports bacterial growth

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13
Q

An open vial of Propofol should be discarded after

A

6 hours

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14
Q

Patients with what allergy may be allergic to Propofol

A

Eggs. Propofol contains egg yolk lecithin

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15
Q

What effects does Propofol have on the central nervous system

A

Hypnosis, sedation, decreased cerebral blood flow, decreased cerebral metabolic requirement for oxygen, decreased intracranial pressure, decreased intraocular pressure, burst suppression on the EEG, anticonvulsant

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16
Q

The analgesic properties of Propofol are

A

Nonexistent

17
Q

Propofol during periods of focal ischemia is

A

neuroprotective

18
Q

Occasional excitatory effects of Propofol seen on induction of anesthesia with Propofol are

A

twitching and spontaneous movement

19
Q

Propofol’s effect on systemic arterial blood pressure

A

Propofol produces a larger decrease in systemic arterial blood pressure than any other drug used for induction of anesthesia

20
Q

Propofol’s effect on peripheral vasculature

A

Profound vasodilatation of both arterial and venous circulation

21
Q

Propofol’s effect on the myocardium

A

Unclear

22
Q

Propofol’s effect on preload

A

Propofol reduces preload

23
Q

Propofol’s effect on afterload

A

Propofol reduces afterload

24
Q

Propofol’s effect on the elderly

A

Propofol’s reduction in blood pressure is more pronounced in the elderly, especially those with reduced intravascular volume

25
Q

Propofol’s effect on the baroreceptor response

A

Propofol markedly inhibits the normal baroreflex response and produces only a small increase in heart rate, thus further exacerbating its hypotensive effect.

26
Q

Propofol can induce arrhythmias they are

A

Bradycardia and asystole can occur in healthy adults despite prophylactic anticholinergics

27
Q

Propofol’s effect on respiration after an induction dose

A

Propofol’s respiratory depressant effects often produce apnea following an induction dose.

28
Q

Propofol’s effect on respiration during a maintenance infusion

A

Propofol reduces minute volume both my decreases in respiratory rate and tidal volume. The decrease in tidal volume is more pronounced.

29
Q

Propofol’s effect on upper airway reflexes

A

Propofol reduces airway reflexes more than pentothal making it well suited for instrumentation of the airway (intubation)

30
Q

Wheezing after Propofol versus Pentothal

A

Propofol decreases the incidence of wheezing after induction of anesthesia and tracheal intubation in healthy and asthmatic patients.

31
Q

Propofol dose for induction of general anesthesia in healthy adults

A

1-2.5 mg/kg IV

32
Q

Propofol dose for induction of general anesthesia in children

A

2.5-3.5 mg/kg IV

33
Q

Continuous infusion rate of Propofol for IV sedation

A

25-75 mcg/kg/min

34
Q

Antiemetic dose of Propofol

A

10-20 mg

35
Q

Propofol side effect noted on injection

A

Pain on injection

36
Q

The presumed mechanism of action of propofol is through

A

potentiation of the chloride current mediated throught he gamma-aminobutyric acid type A (GABA type A) receptor complex

37
Q

What is the beta half-life of Propofol?

A

4-23 hours

Intravenous anesthetics (2 decks)

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