Propofol

Question 1

state the class/family of drugs that Propofol belongs to

Answer 1

hypnotics or anaesthetics

Question 2

Is Propofol a trade or generic name

Answer 2

generic

Question 3

what other name is Propofol known by

Answer 3

Diprivan

Question 4

is this a trade or generic name

Answer 4

trade

Question 5

state the half life of Propofol

Answer 5

estimated between 2 to 24 minutes

Question 6

what schedule of controlled drug is Propofol classified as

Answer 6

schedule IV controlled drug

Question 7

how would Propofol be stored when not in use

Answer 7

in a controlled drugs cabinet, metal, locked and fixed to the wall, Access by 2 people and sign drugs in and out. Records and documentation to be kept for 2 years

Question 8

Propofol is available in what presentation

Answer 8

200mgs in 20mls -10mgs per ml

Question 9

what colour is Propofol

Answer 9

white milky liquid

Question 10

what information can be found stamped on an ampoule

Answer 10

drug name
concentration
batch number
expiry date

Question 11

why is Propofol known as the milk of amnesia

Answer 11

because of its milk like appearance

Question 12

how is Propofol administered on a patient when used for conscious sedation

Answer 12

Propofol is used with a patient-controlled electronic infusion pump driver so that it can be continually administered. the pump driver is set up by the clinicians or the anaesthetist by inputting the amount of drugs a patient will receive each time they press a button and the interval period between activations. This means that the patient is in control, because they hold the button throughout the treatment, which when pressed will administer a dose of Propofol, Due to the date input, they would not receive a dose every time they pressed the button, because of the lock-out time. The initial bolus is approximately 1mg/kg over 1-5minutes followed by 1.5-4.5mg/kg/hour

Question 13

Propofol causes pain on administration, how can this be overcome

Answer 13

by administrating a local anaesthetic into the vein prior to the induction of Propofol

Question 14

who can administer Propofol or dental sedation

Answer 14

anaesthetists and clinicians trained in intensive care procedures. it is normally provided in a hospital setting

Question 15

how does Propofol sedate a patient

Answer 15

it works by enhancing the effect of the GABA to depress the CNA without using the receptors directly

Question 16

what is the approximate onset action time for Propofol

Answer 16

30-45 seconds

Question 17

what are the clinical effects of Propofol

Answer 17

produces sedation and can cause unconsciousness. Causes a 30% fall in blood pressure on induction. Apnoea can occur

Question 18

state 2 contraindications for the use of Propofol

Answer 18

Respiratory depressants such as benzodiazepines, opiates, alcohol, heroin and morphine

Question 19

state two adverse effects that can occur by using Propofol for dental sedation

Answer 19

it is a respiratory depressant. low blood pressure and apnoa. Pain on administration, mild myoclonic movements (muscle twitches) and euphoria. Some patients can experience profound sedation even with a small dose of Propofol. Patients allergic to eggs =. Pregnant and nursing mothers

Question 20

how is Propofol metabolised within the body

Answer 20

in the liver

Question 21

how is Propofol eliminated from the body

Answer 21

in urine from the kidneys

Question 22

if a patient has presented that they can not take Propofol on their medical history due to an allergy, What would they be allergic to

Answer 22

Eggs