Properties acquired by cancer cells

Question 1

Sustaining proliferation signalling

Answer 1

oG1 phase is implicated, Rb protein function is lost.

Question 2

Activating invasion and metastasis

Answer 2

Cancer cells gain the ability to migrate to other parts of the body.

Question 3

Inducing Angiogenesis

Answer 3

promoting growth of new blood vessels to give tumour cells a source of oxygen and nutrients

Question 4

Resisting cell death via lack of apoptosis

Answer 4

Cancer cells also fail to undergo programmed cell death, or apoptosis, under conditions when normal cells would (e.g., due to DNA damage)

Question 5

Emerging hallmarks

Answer 5

•Evading growth suppressors
o Secretion of immunosuppressive factors enables cancers to avoid destruction from the immune system.
•Enabling Replicative immortality
o Metabolic changes that support increased cell growth and division.