Prolonged Pregnancy And Placental Insufficiency Flashcards

1
Q

What is prolonged/ Post term pregnancy?

A

Any pregnancy that lasts 42 completed weeks or more, or 294 days or more

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2
Q

Incidence of prolonged pregnancy

A

5-10% of pregnancies

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3
Q

Causes/Risk Factors of prolonged pregnancy

A
Wrong dating (commonest)
Can be idiopathic
Nulliparity
Previous prolonged pregnancy (50% risk)
Placental sulphatase deficiency (X linked recessive)
Fetal adrenal insufficiency/hypoplasia
Anencephaly 
Male sex
Genetic factors
Obesity
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4
Q

How is diagnosis of prolonged pregnancy made?

A

Based on accurate dating of pregnancy.

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5
Q

Methods used to Date Pregnancy - LMP

A
  1. Use of LMP
    Assumes accurate recall of date and ovulation on the 14th day of the cycle in a 28 day cycle
    🌟Naegle’s rule is based on assumpof a 28 day cycle
    🌟Errors can be due to inaccurate patient recall, maternal preference of date of LMP, and random error.
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6
Q

Methods of Pregnancy Dating - Ultrasound

A

1st Trimester scan most accurate at determining Gestational age. Measures the crown-rump length (CRL; error of +/- 5 days)

🌟Fetal biometry in 2nd Trimester is accurate for dating (error +/- 10 days)

🌟Biometry is most accurate if 2 or more parameters, such as biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length are used together.

🌟With several USG scans, gestational age should be determined by earliest scan (1st trimester scan dating more reliable than LMP)

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7
Q

Other methods of dating

A

Less reliable: Quickening @ 18 weeks (usually)

🌟SFH measurement- 1st SFH measurement on ANC card is fairly accurate and can be used to extrapolate to calculate gestational age.

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8
Q

Risks of Prolonged pregnancy to the Fetus

A
🌟Increased mortality/morbidity 
🌟Macrosomia
🌟Low apgar scores and cord pH
🌟Post maturity syndrome - in 20%
🌟Oligohydramnios
🌟Neonatal encephalopathy 
🌟Cord compression
🌟Meconium aspiration syndrome 
🌟Fetal distress 
🌟Placental dysfunction 
❤️Post term
🌟Death in 1st year of life
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9
Q

Deliver Complications of Prolonged Pregnancy

A
🌟Labour dysfunction 
🌟Shoulder dystopia
🌟Obstetric Trauma
🌟Meconium aspiration 
🌟Birth injuries - fractured bones, peripheral nerve damage
🌟Increased risk of C/S delivery
🌟Fetal and neonatal death
🌟Chorioamnionitis
🌟PPH
🌟Maternal emotional impact
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10
Q

Neonatal Complications of Prolonged Pregnancy

A
🌟Meconium aspiration syndrome (in 5% of meconium stained liqour)
🌟Asphyxia
🌟Hypoglycemia 
🌟Pneumonia
🌟Septicemia
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11
Q

General Principles in Management of Prolonged Pregnancy

A

🌟Conservative
🌟Induction of Labour
🌟Elective C/S

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12
Q

Conservative measures for Prolonged pregnancy

A

Onset of Labour can be awaited for a couple of days after 42 weeks.
🌟While waiting, institute fetal surveillance.
🌟Kick counts
🌟Fetal Doppler
🌟CTG - NST
🌟Amniotic Fluid Index (AFI)
🌟Biophysical profile

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13
Q

Induction of Labour

A
Immediate IOL indicated if there is:
🌟Oligohydramnios 
🌟IUGR
🌟Reduced Fetal movements 
🌟Abnormal CTG findings
🌟Concurrent medical condition 

Ensure the following before induction:
🌟Accurate dating to avoid delivery of preterm Fetus
🌟There is no obstetric contraindication to vaginal delivery
🌟Favourable cervix (Bishop Score >/=6)
🌟Fetus can withstand vagaries of labor (can do contraction stress test
🌟Use of electronic fetal monitoring in labor

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14
Q

Counseling in IOL - Prolonged pregnancy

A

💃🏾Let patient understand that after 42 weeks, perinatal mortality increases 2-fold and no test can guarantee safety of baby.

💃🏾Inductors likely to fail due to abnormal uterine contractions and may be abandoned because of fetal distress.

💃🏾Routine induction at 41+0 to 41+6 does not increase the C/S rate and may decrease it without negatively affecting perinatal morbidity or mortality.

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15
Q

Prevention of Prolonged Pregnancy

A
🌟Accurate dating of Pregnancy 
🌟1st Trimester USG for all pregnancies 
🌟Active measures to end pregnancy after 41 weeks
🌟Membrane sweeping 
🌟Nipple stimulation 
🌟Elective IOL
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16
Q

Membrane Sweeping/Stripping

A

🌟Recommended after 38 weeks
🌟Release local prostaglandins that stimulate uterine contractions
🌟Theoretical risks include: Chorioamnionitis, PROM, bleeding from an undiagnosed placenta praevja

17
Q

Nipple stimulation

A

Frequent Nipple stimulation by patient causes oxytocin release (like let down reflex)

18
Q

Elective IOL

A

🌟Women should be offered IOL at 41+0 to 42+0 weeks

🌟Evidence of decrease in perinatal mortality without increased risk of C/S

19
Q

The PostMaturity Syndrome (PMS)

A

Infants with characteristics of chronic intrauterine growth restriction from uteroplacental insufficiency.

🌟Undernourished fetus suffering because of placental aging and chronic dysfunction.

🌟Described as small old man

🌟Not limited to post dates pregnancy, but can occur earlier when placental insufficiency occurs

🌟20% of post dates babies have PMS

🌟Synonymous with dysmaturity

20
Q

Features of PMS + when diagnosis is made

A

Diagnosis is made after delivery when the following features are present.

🌟Absence of vernix Caseosa and lanugo hair
🌟Abundant scalp hair
🌟Long fingernails
🌟Dry, cracked desquamated skin
🌟Alert and apprehensive facies
🌟Meconium staining of skin and membranes
21
Q

Complications of PMS

A
🌟Ossification of fetal bones
🌟Macrosomia , that may lead to CPD/Prolonged labor/Shoulder dystocia
🌟Placental insufficiency 
🌟Oligohydramnios 
🌟Cord compression (due to Oligohydramnios 
🌟Increased risk of C/S and PPH
🌟IUD/Still Birth
🌟Hypoglycemia 
🌟Hypothermia
🌟Meconium aspiration syndrome
22
Q

Placental Insufficiency

A

A complication of pregnancy- Placenta cannot deliver enough oxygen and nutrients to the fetus and adequately remove waste material.

🌟The earlier in pregnancy this occurs, the severer the complications

🌟May lead to IUGR if present for a long time.

23
Q

Pathology (Etiology of Placental Insufficiency)

A

1 impairment in maternal circulation- from maternal hypertension/ maternal thrombophilic disorders

  1. Impairment in fetal circulation - placental implantation over a fibroid.
  2. Vascular thrombosis- eg. Placental infarction
24
Q

Risk factors for Placental Insufficiency

A
🌟SGA Fetus
🌟Previous SGA infant
🌟Post term pregnancy 
🌟Elderly primigravida
🌟Hypertensive disorders
🌟Diabetes
🌟Renal disease
🌟Multiple pregnancy 
🌟Anemia in pregnancy
25
Q

Diagnosis of Placental Insufficiency- Signs that should arouse suspicion

A

🌟Poor maternal weight gain
🌟Static fundus
🌟Diminished liqour volume
🌟Reduced fetal kicks/movements

26
Q

Diagnosis - Confirming suspicion of placental insufficiency

A
🌟Meconium stained liquor on amnioscopy
🌟Abnormal non-stress tests
🌟Serial biochemistry measurements 
🌟Decreased estriol 
🌟Decreased hPL
🌟Increased alpha detox-protein and hCG in 2nd Trimester

Ultrasound
💃🏾Biometric measurements - HC:AC ratio
💃🏾Uterine artery Doppler in 2nd Trimester
💃🏾Placental morphology in 2nd Trimester - shape and texture.

27
Q

Management of Placental Insufficiency

A

🔥Treat any underlying medical condition
🔥Adequate bed rest
🔥Stop smoking and drinking
🔥Deliver baby at optimum time

28
Q

Complications of Placental Insufficiency

A
🌟Abortions
🌟Stillbirths 
🌟Preterm delivery
🌟IUGR
🌟Low birth weight 
🌟Cerebral palsy
🌟Abruptio placentae